Leila Kohan
YOU?
Author Swipe
View article: MCPyV small T antigen enhances HPV16 oncogene expression, promotes Ca Ski cell proliferation, and reduces 5-fluorouracil-induced apoptosis in cervical cancer cells
MCPyV small T antigen enhances HPV16 oncogene expression, promotes Ca Ski cell proliferation, and reduces 5-fluorouracil-induced apoptosis in cervical cancer cells Open
Background: Cervical cancer is primarily associated with persistent infection by high-risk human papillomaviruses (HR-HPVs), whose oncoproteins modulate key cellular pathways involved in proliferation and apoptosis. Merkel cell polyomaviru…
<i>miR-222</i> and <i>miR-146a</i> Variants in Idiopathic Male Infertility: A Case-Control Study. Open
miR-222 rs2858060 and miR-146a rs2910164 polymorphisms influence the risk of male infertility in Iranian population. This is the first report to examine the role of miR-222 rs2858060 and miR-146a rs2910164 in male infertility, further stud…
View article: The Effects of Preimplantation Genetic Testing and Blastomere Biopsy Sampling on ICSI/IVF Embryos’ Development and Implantation
The Effects of Preimplantation Genetic Testing and Blastomere Biopsy Sampling on ICSI/IVF Embryos’ Development and Implantation Open
Background: Preimplantation genetic diagnosis (PGD) is a diagnostic approach in assisted reproductive technology (ART) to detect and select unaffected embryos to be transferred. Obtaining biopsy samples from embryos (polar body, blastomere…
View article: Embryo quality and chromosomal abnormality in embryos from couples undergoing assisted reproductive technology using preimplantation genetic screening
Embryo quality and chromosomal abnormality in embryos from couples undergoing assisted reproductive technology using preimplantation genetic screening Open
Objective: To detect common chromosomal aneuploidy variations in embryos from couples undergoing assisted reproductive technology and preimplantation genetic screening and their possible associations with embryo quality. Methods: In this s…
Anti-proliferative Effects of Hydroxytyrosol Against Breast Cancer Cell Lines Through Induction of Apoptosis Open
Background: Due to high mortality of patients with metastatic breast cancer and limited strategies for management of this malignancy, development of novel therapeutic approaches and anti-cancer agents is essential. Objectives: In the prese…
Inducible Animal Models of Skin Fibrosis; Updated Review of the Literature Open
Fibrosis is a common and mostly progressive pathological outcome in various chronic inflammatory disorders.Dermal (skin) fibrosis, which is associated with intense skin lesions, is a result of an uncontrolled healing process in the dermis,…
Evaluation of Autophagy Process in Differentiation of Human Induced Pluripotent Stem Cells toward Insulin Producing Cells. Open
This study demonstrated the high contribution of key autophagy genes/proteins during the differentiation of hiPSC toward β-like cells. The enhanced autophagy levels were a prominent feature of early stages of differentiation and DE rather …
The Role of Long Non- Coding RNAs in the Pathogenesis of Multiple Sclerosis Open
Introduction: Multiple sclerosis (MS) is a chronic inflammatory neurological disease with unknown etiology that causes demyelination and axonal damage through the activation of the immune system and entry of leukocytes into the CNS.Althoug…
The Expression of Wnt5a Gene Throughout Definitive Endoderm Induction Process in Induced Pluripotent Stem Cells Open
Background: Induced pluripotent stem cells (iPSCs) have the ability to proliferate indefinitely and differentiate into three germ layers of ectoderm, mesoderm, and endoderm. Definitive induction is the first and the most delicate stage of …
Evaluation of ATG5 Gene Expression in Human Induced Pluripotent Stem Cells During Endoderm Induction Open
Background: Autophagy is a vital cell survival mechanism that authorizes cells to assort to metabolic stress and is essential for the development and maintenance of cellular and tissue homeostasis, as well as the prevention of human diseas…
The effects of placental long noncoding RNA H19 polymorphisms and promoter methylation on H19 expression in association with preeclampsia susceptibility Open
The effect of DNA methylation on gene expression triggered it as a susceptibility factor in various diseases including preeclampsia (PE). The pathogenesis of PE is closely associated with the methylation status and genetic variants of rele…
Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women Open
Background Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms are not well establi…
Investigation of HLA-DRB1*15:03 and HLA-DRB1*09:01 alleles to determine predisposition to development of ABO antibodies (Anti-A and Anti-B) amongst blood donors of type “O” in Southern Iran Open
Introduction: Agglutination in red blood cells can be associated with a number of complications. These complications are related to the amount of antibody titer produced. Some genetic factors, such as HLA-DRB1*15:03 and HLA-DRB1*09:01 alle…
Association of HSPA1B rs6457452 Genetic Variant with Idiopathic Male Infertility Open
\nBackground: Male infertility is a multifactorial disease resulting from the interaction between the genetic and environmental factors. Spermatogenic Failure accounts for more than half of male infertility cases. Heat shock proteins (HSPs…
Association of miR-146a rs2910164 and miR-222 rs2858060 polymorphisms with the risk of polycystic ovary syndrome in Iranian women: A case–control study Open
The present results suggest that the miR-146a rs2910164 and miR-222 rs2858060 polymorphisms are associated with an increased risk of PCOS. Therefore, both polymorphisms could play an important role as a genetic risk factor for development …
Investigating the association of rs1862513 genetic variant in resistin gene with susceptibility to breast cancer Open
Background & objective: Resistin is a unique hormone secreted from adipocytes. Recent data indicated that resistin levels have been associated with inflammatory markers; Due to the fact that chronic inflammation plays a role in breast canc…
Association between Mir-34 b/c rs4938723 Gene Polymorphism and the Risk of Male Infertility Open
Introduction: Infertility is a complex disorder with multiple genetic and environmental causes. Male factor infertility affects 15% of all couples. MicroRNA plays an important role in spermatogenesis. Whether pre-miRNAs polymorphisms are a…
Pharmacogenetic variation of <i>SLC47A1</i> gene and metformin response in type2 diabetes patients. Open
Type 2 diabetes mellitus is a worldwide epidemic disorder with considerable health and economic consequences. Metformin is one of the most commonly prescribed oral antidiabetic drugs. Pharmacogenetic studies showed that variants in genes r…
Role of SIRT-1 rs7895833 polymorphism in susceptibility to polycystic ovary syndrome Open
Introduction: Sirtuin 1 is a protein deacetylase that plays an important role in many cellular processes. The serum sirtuin 1 levels are higher in the polycystic ovary syndrome (PCOS) patients than the healthy subjects. The aim of this stu…
Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary Syndrome Open
Background: Polycystic ovary syndrome(PCOS) is the most common endocrine aberration in women. PCOS is characterized by ovarian hyperandrogenism and anovulation resulted from a disorder of follicular maturation. Apoptosis is a regulatory me…
The Role of rs2227956 HSPA1L Gene Polymorphism in Idiopathic Male Infertility Open
Background & objective: Male infertility is a multifactorial disease resulting from the interaction between the genetic and environmental factors. Despite the methodological advancements, the possible causes of infertility are still unknow…
Omentin-1 rs2274907 and resistin rs1862513 polymorphisms influence genetic susceptibility to nonalcoholic fatty liver disease. Open
Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated disease and dysregulation of adipokines has an important role in its development. Omentin-1 (ITLN1 protein) and resistin are two adipokine secreted from adipose tissue. Sing…
The IL-6 -634C/G polymorphism: a candidate genetic marker for the prediction of idiopathic recurrent pregnancy loss Open
This study indicated that the promoter polymorphism (-634C/G) of the IL-6 gene has likely influence on individual susceptibility to RPL.