Explanipedia

LAT1-NRF2 axis controls sFlt-1/PlGF imbalance and oxidative stress in preeclampsia Open

Sebastian Granitzer, Raimund Widhalm, Isabella Ellinger, Harald Zeisler, Martin Forsthuber , et al. · 2025

Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis Open

Emma Erlich, Quazim A. Alayo, A‐Young Kim, Jichang Han, Rachel L. Mintz , et al. · 2025

Crohn's disease pathology is modeled in TNF^ΔARE+/- mice that overproduce tumor necrosis factor (TNF) to drive disease through TNF receptors. An alternative ligand for TNF receptors, soluble LTα₃, is produced by B cell…

Cells of the Maternal–Fetal Interface May Contribute to Epidural-Related Maternal Fever After Administration of Ropivacaine: The Role of Phosphatases DUSP9 and PHLPP1 Open

Friedemann Horn, Verena Tretter, Victoria Kunihs, Peter Wohlrab, Bettina Trimmel , et al. · 2025

Epidural-related maternal fever (ERMF) occurs with significant incidence in women receiving local anesthetics such as ropivacaine via epidural catheter for pain relief during labor. The causal mechanism behind this phenomenon is still not …

The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta Open

Gudrun Meinhardt, Hanna Waldhäusl, Andreas Ian Lackner, Jasmin Wächter, Theresa Maxian , et al. · 2025

Insights into the molecular processes that drive early development of the human placenta is crucial for our understanding of pregnancy complications such as preeclampsia and fetal growth restriction, since defects in maturation of its epit…

Distinct roles for LTalpha3 and LTalpha1beta2 produced by B cells contribute to their multi-faceted impact on ileitis Open

Gwendalyn J. Randolph, Emma Erlich, Rafael S. Czepielewski, Rachael L. Field, Taylor J Dunning , et al. · 2024

The human placenta shapes the phenotype of decidual macrophages Open

Sigrid Vondra, Anna-Lena Höbler, Andreas Ian Lackner, Johanna Raffetseder, Zala Nikita Mihalič , et al. · 2023

(Cell Reports 42, 111977; January 31, 2023) In the originally published version of this article, Figure 1A contained two identical immunofluorescence (IF) images. The IF picture showing vWF (magenta) and HLA-G (green) was erroneously repea…

Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy Open

Kelsey H. Collins, Lara Pferdehirt, Leila Saleh, Alireza Savadipour, Luke E. Springer , et al. · 2023

Biologic therapies have revolutionized treatment options for rheumatoid arthritis (RA) but their continuous administration at high doses may lead to adverse events. Thus, the development of improved drug delivery systems that can sense and…

The human placenta shapes the phenotype of decidual macrophages Open

Sigrid Vondra, Anna-Lena Höbler, Andreas Ian Lackner, Johanna Raffetseder, Zala Nikita Mihalič , et al. · 2023

During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the decidua and communicate with maternal immune cells. The decidua distinguishes into basalis (decB) and parietalis (decP). The latter remains unaffected by …

Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta Open

Sandra Haider, Andreas Ian Lackner, Bianca Dietrich, Victoria Kunihs, Peter Haslinger , et al. · 2022

Abnormal placentation has been noticed in a variety of pregnancy complications such as miscarriage, early-onset preeclampsia, and fetal growth restriction. Defects in the developmental program of extravillous trophoblasts (EVTs), migrating…

The human placenta shapes the phenotype of decidual macrophages Open

Sigrid Vondra, Anna-Lena Höbler, Andreas Ian Lackner, Johanna Raffetseder, Zala Nikita Mihalič , et al. · 2022

During human pregnancy, placenta-derived extravillous trophoblasts (EVT) invade the decidua and communicate with maternal immune cells. The decidua can be distinguished into basalis (decB) and parietalis (decP), the latter being unaffected…

Mapping Macrophage Polarization and Origin during the Progression of the Foreign Body Response to a Poly(ethylene glycol) Hydrogel Implant Open

Leila Saleh, Luke D. Amer, Brittany J. Thompson, Thomas Danhorn, Jennifer R. Knapp , et al. · 2021

Poly(ethylene glycol) (PEG) hydrogels hold promise for in vivo applications but induce a foreign body response (FBR). While macrophages are key in the FBR, many questions remain. This study investigates temporal changes in the transcriptom…

Interaction of first trimester villous cytotrophoblasts and stromal cells in a 3D-organoid and 2D-hydrogel model Open

Sandra Haider, Marica Marković, Aleksandr Ovsianikov, Jan van Hoorick, Sandra Van Vlierberghe , et al. · 2021

Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta Open

Gudrun Meinhardt, Sandra Haider, Victoria Kunihs, Leila Saleh, Jürgen Pollheimer , et al. · 2020

Various pregnancy complications, such as severe forms of preeclampsia or intrauterine growth restriction, are thought to arise from failures in the differentiation of human placental trophoblasts. Progenitors of the latter either develop i…

Barusiban, a selective oxytocin receptor antagonist: placental transfer in rabbit, monkey, and human† Open

Hanns Helmer, Leila Saleh, Ljubomir Petričević, Martin Knöfler, Torsten Reinheimer · 2020

The use of drugs in pregnancy always raises concerns regarding potential fetal exposure and possible adverse effects through their accumulation in fetal tissues and organs. Barusiban is an oxytocin antagonist under development for potentia…

Inflammation via myeloid differentiation primary response gene 88 signaling mediates the fibrotic response to implantable synthetic poly(ethylene glycol) hydrogels Open

Luke D. Amer, Leila Saleh, Cierra J. Walker, Stacey M. Thomas, William J. Janssen , et al. · 2019

Human placenta and trophoblast development: key molecular mechanisms and model systems Open

Martin Knöfler, Sandra Haider, Leila Saleh, Jürgen Pollheimer, Teena K. J. B. Gamage , et al. · 2019

Abnormal placentation is considered as an underlying cause of various pregnancy complications such as miscarriage, preeclampsia and intrauterine growth restriction, the latter increasing the risk for the development of severe disorders in …

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta Open

Sandra Haider, Gudrun Meinhardt, Leila Saleh, Victoria Kunihs, Magdalena Gamperl , et al. · 2018

Zwitterionic PEG-PC Hydrogels Modulate the Foreign Body Response in a Modulus-Dependent Manner Open

Lauren Jansen, Luke D. Amer, Esther Y. Chen, Thuy V. Nguyen, Leila Saleh , et al. · 2018

Reducing the foreign body response (FBR) to implanted biomaterials will enhance their performance in tissue engineering. Poly(ethylene glycol) (PEG) hydrogels are increasingly popular for this application due to their low cost, ease of use…

The host response in tissue engineering: Crosstalk between immune cells and cell-laden scaffolds Open

Leila Saleh, Stephanie J. Bryant · 2018

The in vitro effects of macrophages on the osteogenic capabilities of MC3T3-E1 cells encapsulated in a biomimetic poly(ethylene glycol) hydrogel Open

Leila Saleh, Maria Carles-Carner, Stephanie J. Bryant · 2018

In vitro and in vivo models for assessing the host response to biomaterials Open

Leila Saleh, Stephanie J. Bryant · 2017

Notch1 controls development of the extravillous trophoblast lineage in the human placenta Open

Sandra Haider, Gudrun Meinhardt, Leila Saleh, Christian Fiala, Jürgen Pollheimer , et al. · 2016

Significance Progenitor trophoblast cells of the human placenta either fuse to form a syncytium or develop into invasive trophoblasts invading the maternal uterus. However, regulatory pathways controlling their development and distinct dif…

Wingless ligand 5a is a critical regulator of placental growth and survival Open

Gudrun Meinhardt, Leila Saleh, Gerlinde R. Otti, Sandra Haider, Philipp Velicky , et al. · 2016

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