Lai Wang
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View article: Chronic liver disease and cirrhosis mortality following surgery for colon or rectal cancer
Chronic liver disease and cirrhosis mortality following surgery for colon or rectal cancer Open
View article: Identification of sensory fiber types in mouse temporomandibular joint tissues
Identification of sensory fiber types in mouse temporomandibular joint tissues Open
View article: The persistent risk of secondary malignancies in gastric neuroendocrine tumor survivors: a population-based analysis
The persistent risk of secondary malignancies in gastric neuroendocrine tumor survivors: a population-based analysis Open
View article: Application and Practice of Personalized Teaching Strategies in Vocal Music Education
Application and Practice of Personalized Teaching Strategies in Vocal Music Education Open
The main purpose of this paper is to deeply study and discuss the application and practical operation of personalized teaching strategies in the field of vocal music education, and analyze in detail how to customize the teaching program ac…
View article: HPK1 kinase inhibitor: a sufficient approach to target HPK1 to modulate T cell activation in cancer immunotherapy compared with degraders
HPK1 kinase inhibitor: a sufficient approach to target HPK1 to modulate T cell activation in cancer immunotherapy compared with degraders Open
Background Hematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family. It has been reported that HPK1 negatively regulates the activation of T cells. Several compounds h…
View article: Machine learning-based simulation and optimization of fluid flow and acid diffusion in uranium in-situ leaching under heterogeneous permeability conditions
Machine learning-based simulation and optimization of fluid flow and acid diffusion in uranium in-situ leaching under heterogeneous permeability conditions Open
View article: Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage Open
View article: Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage
Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage Open
Background Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions reportedly contribute to OA pain pathogenesis…
View article: Lipopolysaccharide released from gut activates pyroptosis of macrophages via Caspase 11‐Gasdermin D pathway in systemic lupus erythematosus
Lipopolysaccharide released from gut activates pyroptosis of macrophages via Caspase 11‐Gasdermin D pathway in systemic lupus erythematosus Open
Noncanonical pyroptosis is triggered by Caspase 4/5/11, which cleaves Gasdermin D (GSDMD), leading to cell lysis. While GSDMD has been studied previously in systemic lupus erythematosus (SLE), the role of pyroptosis in SLE pathogenesis rem…
View article: Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2
Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2 Open
The approval of venetoclax, a B-cell lymphoma-2 (Bcl-2) selective inhibitor, for the treatment of chronic lymphocytic leukemia demonstrated that the antiapoptotic protein Bcl-2 is a druggable target for B-cell malignancies. However, veneto…
View article: Huang Qin decoction increases SLC6A4 expression and blocks the NFκB-mediated NLRP3/Caspase1/GSDMD pathway to disrupt colitis-associated carcinogenesis
Huang Qin decoction increases SLC6A4 expression and blocks the NFκB-mediated NLRP3/Caspase1/GSDMD pathway to disrupt colitis-associated carcinogenesis Open
Huang Qin decoction (HQD) is a traditional Chinese medicine formula for treating colitis, but the effects and molecular mechanism of action of HQD in colitis-associated carcinogenesis (CAC) are still unclear. Therefore, we aimed to determi…
View article: Sonrotoclax overcomes BCL2 G101V mutation–induced venetoclax resistance in preclinical models of hematologic malignancy
Sonrotoclax overcomes BCL2 G101V mutation–induced venetoclax resistance in preclinical models of hematologic malignancy Open
Venetoclax, the first-generation inhibitor of the apoptosis regulator B-cell lymphoma 2 (BCL2), disrupts the interaction between BCL2 and proapoptotic proteins, promoting the apoptosis in malignant cells. Venetoclax is the mainstay of ther…
View article: 765P SABRINA study: A phase II study of senaparib monotherapy for patients (pts) with BRCA1/2 mutated recurrent platinum-sensitive ovarian cancer (PSOC)
765P SABRINA study: A phase II study of senaparib monotherapy for patients (pts) with BRCA1/2 mutated recurrent platinum-sensitive ovarian cancer (PSOC) Open
View article: Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis Open
Non-opioid targets are needed for addressing osteoarthritis pain, which is mechanical in nature and associated with daily activities such as walking and climbing stairs. Piezo2 has been implicated in the development of mechanical pain, but…
View article: Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain
Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain Open
Background We aimed to explore activation of the Notch signaling pathway in knee-innervating lumbar dorsal root ganglia (DRG) in the course of experimental osteoarthritis (OA) in mice, and its role in knee hyperalgesia. Methods Cultured DR…
View article: 14, <scp>15‐EET</scp> alleviates neurological impairment through maintaining mitochondrial dynamics equilibrium via <scp>AMPK</scp>/<scp>SIRT1</scp>/<scp>FoxO1</scp> signal pathways in mice with cerebral ischemia reperfusion
14, <span>15‐EET</span> alleviates neurological impairment through maintaining mitochondrial dynamics equilibrium via <span>AMPK</span>/<span>SIRT1</span>/<span>FoxO1</span> signal pathways in mice with cerebral ischemia reperfusion Open
Aim To explore whether 14, 15‐EET regulates mitochondrial dynamics to exert neuroprotective effects after cerebral ischemia–reperfusion and its underlying mechanisms. Methods The mouse middle cerebral artery occlusion reperfusion model was…
View article: Data from Lung-Cancer Chemoprevention by Induction of Synthetic Lethality in Mutant <i>KRAS</i> Premalignant Cells <i>In Vitro</i> and <i>In Vivo</i>
Data from Lung-Cancer Chemoprevention by Induction of Synthetic Lethality in Mutant <i>KRAS</i> Premalignant Cells <i>In Vitro</i> and <i>In Vivo</i> Open
Lung cancer is the leading cause of cancer death in both men and women in the United States, with a low 5-year survival rate despite improved treatment strategies. These data underscore the great need for effective chemoprevention of this …
View article: Data from Lung-Cancer Chemoprevention by Induction of Synthetic Lethality in Mutant <i>KRAS</i> Premalignant Cells <i>In Vitro</i> and <i>In Vivo</i>
Data from Lung-Cancer Chemoprevention by Induction of Synthetic Lethality in Mutant <i>KRAS</i> Premalignant Cells <i>In Vitro</i> and <i>In Vivo</i> Open
Lung cancer is the leading cause of cancer death in both men and women in the United States, with a low 5-year survival rate despite improved treatment strategies. These data underscore the great need for effective chemoprevention of this …
View article: Supplementary Table 5 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Supplementary Table 5 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
PDF file - 69K, H1395 cells were transfected with firefly luciferase siRNA, cIAP1 siRNA, cIAP2 siRNA, XIAP siRNA, caspase 3 siRNA, caspase 4 siRNA, caspase 9 siRNA, caspase 8 siRNA, RIPK1 siRNA, TNFR1 siRNA, or cIAP1, cIAP2, and XIAP siRNA…
View article: Supplementary Table 1 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Supplementary Table 1 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
PDF file - 674K, Cells labeled with tumor type of NSCLC have an undetermined histotype. Genes listed in the table have mutations in the tumor lines marked with +, determined by sequencing by the Sanger Center (Forbes et al., 2001). Tumor t…
View article: Supplementary Table 7 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Supplementary Table 7 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
PDF file - 72K, There are significant negative and positive correlations with various oncogene and tumor suppression gene mutations. * Bold figures identify significant Pearson correlations (p<0.05).
View article: Supplementary Figure 2 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Supplementary Figure 2 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
PDF file - 671K, A, H358, D, H1819, G, H2887 treated with gemcitabine alone (brown circles), or treated with gemcitabine in the presence of 10 mM JP1201 (red diamonds), luciferase siRNA (black circles), cIAP1 siRNA (blue triangles), cIAP2 …
View article: Supplementary Figure 4 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Supplementary Figure 4 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
PDF file - 69K, Western blot analysis of activated caspase 4 after chemotherapy treatment. H1395 cells were treated with 500 nM gemcitabine, 100 nM vinorelbine, or 500 nM thapsigargan (a known ER stress inducer), samples were collected as …
View article: Supplementary Table 5 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Supplementary Table 5 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
PDF file - 69K, H1395 cells were transfected with firefly luciferase siRNA, cIAP1 siRNA, cIAP2 siRNA, XIAP siRNA, caspase 3 siRNA, caspase 4 siRNA, caspase 9 siRNA, caspase 8 siRNA, RIPK1 siRNA, TNFR1 siRNA, or cIAP1, cIAP2, and XIAP siRNA…
View article: Supplementary Table 3 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Supplementary Table 3 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
PDF file - 57K, Combination indices (CI) were calculated using the Chou‐Talay method (Chou and Rideout, 1991). CI values that are less than 1 � 0.2 indicate synergy, values that are equal to 1 � 0.2 indicate additivity, and values that are…
View article: Supplementary Table 4 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Supplementary Table 4 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
PDF file - 45K, Cells were seeded at 500 cells per well in 6 well dishes. The appropriate concentrations of drug were prepared from stock solutions in medium and given to cells for 10-28 days depending on the cell line. At the end of the a…
View article: Data from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Data from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
Inhibitors of apoptosis proteins (IAP) are key regulators of apoptosis and are inhibited by the second mitocondrial activator of caspases (SMAC). Previously, a small subset of TNF-α–expressing non–small cell lung cancers (NSCLC) was found …
View article: Supplementary Table 4 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Supplementary Table 4 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
PDF file - 45K, Cells were seeded at 500 cells per well in 6 well dishes. The appropriate concentrations of drug were prepared from stock solutions in medium and given to cells for 10-28 days depending on the cell line. At the end of the a…
View article: Supplementary Table 6 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Supplementary Table 6 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
PDF file - 58K, Cell growth assays were performed in 96 well format for 5 days. Cells were plated on day zero and exposed to drug for four days before cell survival was determined using MTS (Promega; final concentration, 333 mg/mL) read at…
View article: Supplementary Figure 2 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner
Supplementary Figure 2 from SMAC Mimetic (JP1201) Sensitizes Non–Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α–Independent Manner Open
PDF file - 671K, A, H358, D, H1819, G, H2887 treated with gemcitabine alone (brown circles), or treated with gemcitabine in the presence of 10 mM JP1201 (red diamonds), luciferase siRNA (black circles), cIAP1 siRNA (blue triangles), cIAP2 …