Li Huo
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View article: Predictive Accuracy of a Clinical Model for Identifying Pathogenic Gene Carriers in Dementia Patients with a Family History at PUMCH
Predictive Accuracy of a Clinical Model for Identifying Pathogenic Gene Carriers in Dementia Patients with a Family History at PUMCH Open
Background Identifying carriers of pathogenic or likely pathogenic gene variants in dementia is crucial for risk stratification, particularly in individuals with a family history. This study aimed to develop and validate a clinical predict…
View article: Real‐World Clinical Practice of Lecanemab at PUMCH: Focus on Dynamic Imaging and Biomarker Evolution
Real‐World Clinical Practice of Lecanemab at PUMCH: Focus on Dynamic Imaging and Biomarker Evolution Open
Background Lecanemab was widely used in China since June 2024 . Its real‐world efficacy and safety profile have attracted significant attention. The aim of the study is to evaluate the clinical outcomes, adverse effects, and dynamic follow…
View article: 68Ga-NY104 PET/CT in the Differential Diagnosis of FDG-Negative Renal Masses: A Two-Case Illustration of Clear Cell Carcinoma Versus Renal Hemangioma
68Ga-NY104 PET/CT in the Differential Diagnosis of FDG-Negative Renal Masses: A Two-Case Illustration of Clear Cell Carcinoma Versus Renal Hemangioma Open
FDG PET/CT often underperforms in characterizing hyper-enhancing, FDG-non-avid renal masses. We present two cases illustrating the potential of 68Ga-NY104, a novel small-molecule tracer targeting carbonic anhydrase IX (CAIX), for this diff…
View article: Prognostic value of 68Ga-DOTATATE PET/CT in assessing cardiac involvement in autoimmune diseases: a prospective study
Prognostic value of 68Ga-DOTATATE PET/CT in assessing cardiac involvement in autoimmune diseases: a prospective study Open
Background This prospective study aimed to evaluate the prognostic value of 68 Ga-DOTATATE PET/CT imaging in assessing myocardial macrophage infiltration in patients with autoimmune diseases and its relationship with clinical outcomes, spe…
View article: Autoregressive translation model design integrating syntactic encoding computation and reinforcement learning: a framework for enhancing translation optimization
Autoregressive translation model design integrating syntactic encoding computation and reinforcement learning: a framework for enhancing translation optimization Open
This study proposes an autoregressive translation model that integrates syntactic encoding computation and reinforcement learning. The model enhances positional encoding by leveraging the strengths of linear transformer and adaptive Fourie…
View article: Preclinical Evaluation of a Novel Carbonic Anhydrase IX-Targeting 68Ga/177Lu Theranostic Pair for Clear Cell Renal Cell Carcinoma
Preclinical Evaluation of a Novel Carbonic Anhydrase IX-Targeting 68Ga/177Lu Theranostic Pair for Clear Cell Renal Cell Carcinoma Open
Background Carbonic anhydrase IX (CAIX) is a hypoxia-regulated enzyme overexpressed in clear cell renal cell carcinoma (ccRCC) but minimally in normal tissues, making it a promising theranostic target. Current imaging modalities for ccRCC …
View article: 68Ga-pentixafor PET/CT versus adrenal venous sampling in guiding surgical management for primary aldosteronism: a prospective cohort study on postoperative outcomes
68Ga-pentixafor PET/CT versus adrenal venous sampling in guiding surgical management for primary aldosteronism: a prospective cohort study on postoperative outcomes Open
Background: Limitations still exist in the surgical strategies for primary aldosteronism (PA), the most common cause of secondary hypertension. This study aimed to compare the effectiveness of 68 Ga-pentixafor PET/CT versus adrenal venous …
View article: 99mTc-Labeled FAPI SPECT and 18F-FDG PET Imaging for Visualization and Evaluation of Connective Tissue Disease-associated Interstitial Lung Disease
99mTc-Labeled FAPI SPECT and 18F-FDG PET Imaging for Visualization and Evaluation of Connective Tissue Disease-associated Interstitial Lung Disease Open
Background The pathogenesis of connective tissue disease-associated interstitial lung disease (CTD-ILD) involves complex interactions between inflammatory cell infiltration and fibroblast activation, which are pivotal in driving the diseas…
View article: The Significant Role of Nitrogen Protonation in the Rational Design of Tau-PET Tracers
The Significant Role of Nitrogen Protonation in the Rational Design of Tau-PET Tracers Open
As an important biomarker in Alzheimer’s disease (AD), abnormal Tau accumulation is closely associated with neurodegeneration and cognitive impairment. Positron emission tomography (PET) imaging of Tau offers a non-invasive and precise dia…
View article: Feasibility of simplified Patlak parametric imaging with scaled population-based input function on pancreatic cancer
Feasibility of simplified Patlak parametric imaging with scaled population-based input function on pancreatic cancer Open
The sPBIF approach enables the acquisition of additional Patlak parametric images alongside static SUV imaging in pancreatic cancer patients. Ki parametric imaging provided higher contrast than static imaging for detecting pancreatic lesio…
View article: Predictive Accuracy of a Clinical Model for Carriage of Pathogenic/Likely Pathogenic Variants in Patients with Dementia and a Positive Family History at PUMCH
Predictive Accuracy of a Clinical Model for Carriage of Pathogenic/Likely Pathogenic Variants in Patients with Dementia and a Positive Family History at PUMCH Open
Background and Objectives: Identifying carriers of Pathogenic/Likely Pathogenic Variants in patients with dementia is crucial for risk stratification, particularly in individuals with a family history. This study developed and validated a …
View article: Diagnostic performance of [68Ga]Ga-FAPI-04 PET vs. [18F]FDG PET in detecting lymph node metastasis in digestive system cancers: a head-to-head comparative meta-analysis
Diagnostic performance of [68Ga]Ga-FAPI-04 PET vs. [18F]FDG PET in detecting lymph node metastasis in digestive system cancers: a head-to-head comparative meta-analysis Open
Purpose This meta-analysis aimed to compare the diagnostic effectiveness of [ 68 Ga]Ga-FAPI-04 PET and [ 18 F]FDG PET for detecting lymph node metastasis in digestive system cancer patients. Methods A comprehensive search of PubMed, Web of…
View article: Computational Fluid Dynamics Investigation of Aerodynamic Characteristics of Landing Phase of Reusable Launch Vehicle
Computational Fluid Dynamics Investigation of Aerodynamic Characteristics of Landing Phase of Reusable Launch Vehicle Open
Reusable launch systems have received increasing interest because their potential to significantly reduce launch costs. Many studies have focused on the supersonic retro-propulsion phase including experiments and numerical simulations. In …
View article: Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor
Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor Open
Inflammatory myofibroblastic tumor (IMT) is a rare spindle‐cell neoplasm. IMT currently suffers from a paucity of standardized diagnostic and therapeutic guidelines. The Chinese expert consensus committee on the diagnosis and treatment of …
View article: [18F]F-FES PET for diagnosis, staging, and endocrine therapy prediction in ER-positive breast cancer: a systematic review and meta-analysis
[18F]F-FES PET for diagnosis, staging, and endocrine therapy prediction in ER-positive breast cancer: a systematic review and meta-analysis Open
[18F]F-FES PET/CT is valuable for diagnosing and staging ER + breast cancer, assessing ER status, and predicting response to endocrine therapy. Its implementation can improve treatment planning and patient outcomes in breast cancer managem…
View article: Performance Characteristics of a New Generation 148-cm Axial Field-of-View uMI Panorama GS PET/CT System with Extended NEMA NU 2-2018 and EARL Standards
Performance Characteristics of a New Generation 148-cm Axial Field-of-View uMI Panorama GS PET/CT System with Extended NEMA NU 2-2018 and EARL Standards Open
The uMI Panorama GS PET/CT system is a new long-axial-field-of-view scanner featuring high sensitivity, time-of-flight (TOF) resolution, spatial resolution, and count rate performance. The aim of this study is to assess the PET system on t…
View article: Retinal curvature in Chinese children with myopia measured by ultra-widefield swept-source optical coherence tomography
Retinal curvature in Chinese children with myopia measured by ultra-widefield swept-source optical coherence tomography Open
Aims To quantitatively measure retinal curvature (RC) in children with myopia and explore its association with refractive status. Methods This cross-sectional study included participants aged 5–18 years who underwent comprehensive ocular e…
View article: Clinical characteristics and surgical outcomes of vertebral lesions associated with tumor-induced osteomalacia: report of 16 patients and review of the literature
Clinical characteristics and surgical outcomes of vertebral lesions associated with tumor-induced osteomalacia: report of 16 patients and review of the literature Open
68 Ga-DOTATATE PET/CT could serve as the first diagnostic tool in patients with vertebral TIO, and segmental resection could be used as the preferred surgery. This study would raise awareness of the clinical features and management of thes…
View article: Consensus on the clinical diagnosis and treatment of grade 3 pancreatic neuroendocrine tumors
Consensus on the clinical diagnosis and treatment of grade 3 pancreatic neuroendocrine tumors Open
The World Health Organization (WHO) 2017 classifications for neuroendocrine neoplasms (NENs) subdivided grade 3 pancreatic neuroendocrine neoplasms (pNENs) into G3 well-differentiated pancreatic neuroendocrine tumors (G3 pNETs) and poorly …
View article: Preclinical evaluation of the theranostic potential of 89Zr/177Lu-labeled anti-TROP-2 antibody in triple-negative breast cancer model
Preclinical evaluation of the theranostic potential of 89Zr/177Lu-labeled anti-TROP-2 antibody in triple-negative breast cancer model Open
Background Triple-negative breast cancer (TNBC) is one of the most lethal malignant tumors among women, characterized by high invasiveness, high heterogeneity, and lack of specific therapeutic targets such as estrogen receptor, progesteron…