Leixiang Yang
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View article: Combining Selenocystine Based Fluorescence Assay with Structural Prediction for Enhanced Detection and Analysis of Cystine Stone Pathology
Combining Selenocystine Based Fluorescence Assay with Structural Prediction for Enhanced Detection and Analysis of Cystine Stone Pathology Open
Background Cystine stones, a rare but recurrent type of kidney stones, primarily result from cystinuria, an inherited disorder caused by mutations in the genes SLC3A1 and SLC7A9 , which encode renal cystine transporters. These mutations im…
View article: Bcl-xL Inhibition Disrupts p27 Stability and Promotes Senescence Escape: Insights for Cancer Senotherapy
Bcl-xL Inhibition Disrupts p27 Stability and Promotes Senescence Escape: Insights for Cancer Senotherapy Open
Purpose: Cellular senescence serves as a double-edged sword in oncology, acting as a tumor suppressor and a promoter of a pro-tumorigenic environment post-chemotherapy, necessitating targeted removal strategies. To investigate whether inhi…
View article: Immunogenic chemotherapy: great potential for improving response rates
Immunogenic chemotherapy: great potential for improving response rates Open
The activation of anti-tumor immunity is critical in treating cancers. Recent studies indicate that several chemotherapy agents can stimulate anti-tumor immunity by inducing immunogenic cell death and durably eradicate tumors. This suggest…
View article: Identification and characterization of novel compound heterozygous variants in FSHR causing primary ovarian insufficiency with resistant ovary syndrome
Identification and characterization of novel compound heterozygous variants in FSHR causing primary ovarian insufficiency with resistant ovary syndrome Open
Primary ovarian insufficiency (POI) is among the foremost causes of women infertility due to premature partial or total loss of ovarian function. Resistant ovary syndrome (ROS) is a subtype of POI manifested as normal ovarian reserve but i…
View article: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain
Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain Open
Bromodomains regulate chromatin remodeling and gene transcription through recognition of acetylated lysines on histones and other proteins. Bromodomain-containing protein TAF1, a subunit of general transcription factor TFIID, initiates pre…
View article: Ligand-induced global conformational changes in TBP-associated factor 1 (TAF1) tandem bromodomains – a novel strategy for targeting the TAF1
Ligand-induced global conformational changes in TBP-associated factor 1 (TAF1) tandem bromodomains – a novel strategy for targeting the TAF1 Open
Targeting bromodomains by small molecule inhibitors is a novel therapeutic strategy to regulate various cellular functions of bromodomain-containing proteins.These inhibitors have been shown to regulate altered chromatin remodeling and abe…
View article: Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein–Protein Interactions
Rational Design of Right-Handed Heterogeneous Peptidomimetics as Inhibitors of Protein–Protein Interactions Open
Peptidomimetics have gained great attention for their function as protein-protein interaction (PPI) inhibitors. Herein, we report the design and investigation of a series of right-handed helical heterogeneous 1:1 α/Sulfono-γ-AA peptides as…
View article: Correction to α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions
Correction to α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions Open
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein InteractionsPeng SangPeng SangMore by Peng …
View article: α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions
α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions Open
The use of peptidomimetic scaffolds is a promising strategy for the inhibition of protein-protein interactions (PPIs). Herein, we demonstrate that sulfono-γ-AApeptides can be rationally designed to mimic the p53 α-helix and inhibit p53-MDM…
View article: Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity
Mutant p53 Sequestration of the MDM2 Acidic Domain Inhibits E3 Ligase Activity Open
Missense p53 mutants often accumulate in tumors and drive progression through gain of function. MDM2 efficiently degrades wild-type p53 but fails to degrade mutant p53 in tumor cells. Previous studies revealed that mutant p53 inhibits MDM2…
View article: MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis
MDMX acidic domain inhibits p53 DNA binding in vivo and regulates tumorigenesis Open
Significance MDMX is an important regulator of p53 during embryonic development and malignant transformation. Using a combination of mouse knockin model, cell culture, and biochemical analysis, we demonstrate that the MDMX acidic domain in…
View article: Tumor cell senescence response produces aggressive variants
Tumor cell senescence response produces aggressive variants Open
Tumors often respond favorably to initial chemotherapy but eventually relapse with drug resistance and increased metastatic potential. Cellular senescence is a major therapeutic outcome of cancer chemotherapy, which leads to tumor stasis o…