Lekhika Pathak
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View article: Hypoxia-driven mobilization of altruistic cancer stem cells in platinum-treated head and neck cancer
Hypoxia-driven mobilization of altruistic cancer stem cells in platinum-treated head and neck cancer Open
Background Head and neck cancers harbor dormant cancer stem cells (CSCs). This study explores how platinum therapy impacts these cells in a non-genetic manner and the role of hypoxia in this process. Previously, we identified a novel popul…
View article: A novel comprehensive Tuberculosis (TB) control programme methodology based on the nexus of participatory action research inspired public health and precision treatment approach
A novel comprehensive Tuberculosis (TB) control programme methodology based on the nexus of participatory action research inspired public health and precision treatment approach Open
Tuberculosis is emerging as a major global health issue for the under-developed regions across the world including India’s North East. Importantly, the incidence of multidrug-resistant (MDR) strain of Mycobacterium tuberculosis (MTB), the …
View article: The emerging role of oral microbiota in oral cancer initiation, progression and stemness
The emerging role of oral microbiota in oral cancer initiation, progression and stemness Open
Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy among the Head and Neck cancer. OSCCs are highly inflammatory, immune-suppressive, and aggressive tumors. Recent sequencing based studies demonstrated the involvement of …
View article: <i>Fusobacterium nucleatum</i>present in the saliva of oral cancer subjects can activate niche defense of oral squamous cell carcinoma
<i>Fusobacterium nucleatum</i>present in the saliva of oral cancer subjects can activate niche defense of oral squamous cell carcinoma Open
Oral cancer is a subset of head and neck cancer (HNC), has a high incidence rate in this malignancy group. Cancer Stem Cells (CSCs) are population of the heterogeneous malignant cells present within oral tumor microenvironment. CSCs’ stemn…
View article: An IndoAmerican Medical Humanities program promoting Kamrup's IKS-based healthcare: a model for innovative rural and global health practices
An IndoAmerican Medical Humanities program promoting Kamrup's IKS-based healthcare: a model for innovative rural and global health practices Open
Background/Rationale: The Medical Humanities is an emerging educational field gaining traction in medical institutions of the U.S., U.K, and other countries abroad. Its purpose is to emphasize the interdisciplinary nature of medicine and v…
View article: Abstract 2772: The development of immunotherapy agents from the indigenous herbal plants and microbes used by the tantric practitioner of Vedic Jiva Upakara Cikitsha Tantra (Vedic altruism-based medicine system) of Assam, India
Abstract 2772: The development of immunotherapy agents from the indigenous herbal plants and microbes used by the tantric practitioner of Vedic Jiva Upakara Cikitsha Tantra (Vedic altruism-based medicine system) of Assam, India Open
The ancient India's indigenous tantric community had its unique medicinal philosophy as well as clinical practice, distinct from Ayurveda. One such tantric community was Assam's Vedic Jiva Upakarvada practitioners (1). These practitioners …
View article: 90 Circulating altruistic stem cells as a marker of immunosuppression in oral cancer
90 Circulating altruistic stem cells as a marker of immunosuppression in oral cancer Open
Background Head & neck cancer is the 4th cancer, and most of them are diagnosed late, and treated with cisplatin monotherapy. In these subsets of patients, immunotherapy has been tried, but without major success.1 We speculate that circula…
View article: Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense
Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense Open
Tumor hypoxia and oxidative stress reprograms cancer stem cells (CSCs) to a highly aggressive and inflammatory phenotypic state of tumor stemness. Previously, we characterized tumor stemness phenotype in the ATP Binding Cassette Subfamily …
View article: A Vedic Jiva Upakara Cikitsha Tantra (Vedic altruism) based telemedicine program for rural health care in India
A Vedic Jiva Upakara Cikitsha Tantra (Vedic altruism) based telemedicine program for rural health care in India Open
In this post-covid19 era, there is an immense need for telemedicine care for rural people of the developing world including India. Through telemedicine care, novel digital therapeutic devices may be operated to provide rural health care, s…
View article: Targeting tumor stemness switch phenotype by activating pathogen induced stem cell niche defense
Targeting tumor stemness switch phenotype by activating pathogen induced stem cell niche defense Open
Cancer stem cells (CSCs) reside in their tumor microenvironment (TME) niches, which are often hypoxic. Previously, we found that hypoxia and oxidative stress prevalent in TME may reprogram CSCs to a highly aggressive and inflammatory pheno…
View article: Initiation of Post-Primary Tuberculosis of the Lungs: Exploring the Secret Role of Bone Marrow Derived Stem Cells
Initiation of Post-Primary Tuberculosis of the Lungs: Exploring the Secret Role of Bone Marrow Derived Stem Cells Open
Mycobacterium tuberculosis ( Mtb ), the causative organism of pulmonary tuberculosis (PTB) now infects more than half of the world population. The efficient transmission strategy of the pathogen includes first remaining dormant inside the …
View article: Stem cell basis of a host driven transmission of antigen packed aerosols: a novel mechanism of natural vaccination for tuberculosis
Stem cell basis of a host driven transmission of antigen packed aerosols: a novel mechanism of natural vaccination for tuberculosis Open
Natural vaccination against pathogens are known to be achieved by herd-immunity i.e. infected human host provide immunity to the community by spreading the pathogen. Whether, infected human hosts transmit vesicle packed aerosols of pathoge…