Leland C. Sudlow
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View article: Identification Drug Targets for Oxaliplatin-Induced Cardiotoxicity without Affecting Cancer Treatment through Inter Variability Cross-Correlation Analysis (IVCCA)
Identification Drug Targets for Oxaliplatin-Induced Cardiotoxicity without Affecting Cancer Treatment through Inter Variability Cross-Correlation Analysis (IVCCA) Open
The successful treatment of side effects of chemotherapy faces two major limitations: the need to avoid interfering with pathways essential for the cancer-destroying effects of the chemotherapy drug, and the need to avoid helping tumor pro…
View article: DRG Explant Model: Elucidating Mechanisms of Oxaliplatin-Induced Peripheral Neuropathy and Identifying Potential Therapeutic Targets
DRG Explant Model: Elucidating Mechanisms of Oxaliplatin-Induced Peripheral Neuropathy and Identifying Potential Therapeutic Targets Open
Oxaliplatin triggered chemotherapy induced peripheral neuropathy (CIPN) is a common and debilitating side effect of cancer treatment which limits the efficacy of chemotherapy and negatively impacts patients quality of life dramatically. Fo…
View article: Oxaliplatin-induced cardiotoxicity in mice is connected to the changes in energy metabolism in the heart tissue
Oxaliplatin-induced cardiotoxicity in mice is connected to the changes in energy metabolism in the heart tissue Open
Oxaliplatin is a platinum-based alkylating chemotherapeutic agent used for cancer treatment. At high cumulative dosage, the negative effect of oxaliplatin on the heart becomes evident and is linked to a growing number of clinical reports. …
View article: 3D Media Stabilizes Membrane and Prolongs Lifespan of Defolliculated Xenopus laevis Oocytes
3D Media Stabilizes Membrane and Prolongs Lifespan of Defolliculated Xenopus laevis Oocytes Open
Xenopus laevis oocytes are commonly used in many fundamental biological studies. One of the major limitations of X. laevis oocytes is their short storage lifespan with most defolliculated oocytes physically deteriorating in 10 days or less…
View article: CCDC 1984333: Experimental Crystal Structure Determination
CCDC 1984333: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1984334: Experimental Crystal Structure Determination
CCDC 1984334: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1984335: Experimental Crystal Structure Determination
CCDC 1984335: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: New in vitro highly cytotoxic platinum and palladium cyanoximates with minimal side effects in vivo
New in vitro highly cytotoxic platinum and palladium cyanoximates with minimal side effects in vivo Open
View article: Using Xenopus oocytes in neurological disease drug discovery
Using Xenopus oocytes in neurological disease drug discovery Open
Introduction: Neurological diseases present a difficult challenge in drug discovery. Many of the current treatments have limited efficiency or result in a variety of debilitating side effects. The search of new therapies is of a par…
View article: Fluorescence lifetime imaging reveals heterogeneous functional distribution of eGFP expressed in <i>Xenopus</i> oocytes
Fluorescence lifetime imaging reveals heterogeneous functional distribution of eGFP expressed in <i>Xenopus</i> oocytes Open
The oocytes from Xenopus laevis are well known for their polarity, presenting a distinct animal and vegetal pole. Other heterogeneities are less known. To study the heterogeneity of the Xenopus oocyte, we expressed eGFP and analyzed the pr…
View article: Imaging in the Repair of Peripheral Nerve Injury
Imaging in the Repair of Peripheral Nerve Injury Open
Surgical intervention followed by physical therapy remains the major way to repair damaged nerves and restore function. Imaging constitutes promising, yet underutilized, approaches to improve surgical and postoperative techniques. Dedicate…
View article: cAMP, Ca<sup>2+</sup>, pH<sub>i</sub>, and NO Regulate H-like Cation Channels That Underlie Feeding and Locomotion in the Predatory Sea Slug <i>Pleurobranchaea californica</i>
cAMP, Ca<sup>2+</sup>, pH<sub>i</sub>, and NO Regulate H-like Cation Channels That Underlie Feeding and Locomotion in the Predatory Sea Slug <i>Pleurobranchaea californica</i> Open
A systems approach to regulation of neuronal excitation in the mollusc Pleurobranchaea has described novel interactions of cyclic AMP-gated cation current (INa,cAMP), Ca2+, pHi, and NO. INa,cAMP …