Lena Griesbaum
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View article: The HL-60 clone 15 cell line as a model for leukocyte migration–possibilities and limitations
The HL-60 clone 15 cell line as a model for leukocyte migration–possibilities and limitations Open
Introduction As a part of the innate immune system, eosinophils are recruited during infectious diseases, to release their characteristic cytotoxic granules and catch pathogens in extracellular traps. Moreover, eosinophils have a crucial r…
View article: SARS-CoV-2 S1 protein induces IgG-mediated platelet activation and is prevented by 1.8-cineole
SARS-CoV-2 S1 protein induces IgG-mediated platelet activation and is prevented by 1.8-cineole Open
COVID-19 patients face an increased risk of thromboembolic complications, yet the exact pathophysiological role of platelets in the disease remains unclear. Considering the multifaceted nature of COVID-19 symptoms, including platelet hyper…
View article: 1.8-cineole prevents platelet activation and aggregation by activating the cAMP pathway via the adenosine A2A receptor
1.8-cineole prevents platelet activation and aggregation by activating the cAMP pathway via the adenosine A2A receptor Open
Given the recognized anti-inflammatory attributes of 1.8-cineole, coupled with our findings, 1.8-cineole might emerge as a promising candidate for treating conditions marked by platelet activation and abnormal inflammation.
View article: Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates
Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates Open
In recent years, isothiocyanates (ITCs), bioactive compounds primarily derived from Brassicaceae vegetables and herbs, have gained significant attention within the biomedical field due to their versatile biological effects. This comprehens…
View article: Antibodies against malondialdehyde among 60-year-olds: prediction of cardiovascular disease
Antibodies against malondialdehyde among 60-year-olds: prediction of cardiovascular disease Open
Malondialdehyde (MDA) is generated in oxidized LDL. It forms covalent protein adducts, and is recognized by antibodies (anti-MDA). We previously studied IgM anti-MDA, and here we focus on IgG, IgG1 and IgG2 anti-MDA in predicting cardiovas…
View article: 1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases Open
1,8-cineole (Eucalyptol), a naturally occurring compound derived from botanical sources such as eucalyptus, rosemary, and camphor laurel, has a long history of use in traditional medicine and exhibits an array of biological properties, inc…