Lena Jonasson
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View article: Plasma carotenoids are inversely correlated with granulocyte counts and soluble inflammatory markers in a middle-aged population: a cross-sectional study with mediation analysis
Plasma carotenoids are inversely correlated with granulocyte counts and soluble inflammatory markers in a middle-aged population: a cross-sectional study with mediation analysis Open
Background High intake of fruits and vegetables is generally associated with reduced levels of inflammation. In line with this, plasma levels of carotenoids have shown inverse associations with inflammatory markers, in particular C-reactiv…
View article: Basal and exercise-induced expression of NLRP3 inflammasome-related components is increased in patients with chronic coronary syndrome
Basal and exercise-induced expression of NLRP3 inflammasome-related components is increased in patients with chronic coronary syndrome Open
View article: Follow-up of incidentally detected mild to moderate ascending aortic dilation and risk factors for rapid progression in a Swedish middle-aged population
Follow-up of incidentally detected mild to moderate ascending aortic dilation and risk factors for rapid progression in a Swedish middle-aged population Open
Background Thoracic aortic aneurysm is a life-threatening disease due to the risk for acute aortic syndromes, and subjects with dilated ascending aortas are recommended surveillance imaging to assess the need for preventive surgery. Our ob…
View article: Self‐Report Tool for Identification of Individuals With Coronary Atherosclerosis: The Swedish CardioPulmonary BioImage Study
Self‐Report Tool for Identification of Individuals With Coronary Atherosclerosis: The Swedish CardioPulmonary BioImage Study Open
Background Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether nonimaging data, specifically…
View article: Wall shear stress measured with 4D flow CMR correlates with biomarkers of inflammation and collagen synthesis in mild-to-moderate ascending aortic dilation and tricuspid aortic valves
Wall shear stress measured with 4D flow CMR correlates with biomarkers of inflammation and collagen synthesis in mild-to-moderate ascending aortic dilation and tricuspid aortic valves Open
Aims Understanding the mechanisms underlying ascending aortic dilation is imperative for refined risk stratification of these patients, particularly among incidentally identified patients, most commonly presenting with tricuspid valves. Th…
View article: A self-report tool for identification of individuals with coronary atherosclerosis – The Swedish CArdioPulmonary BioImage Study
A self-report tool for identification of individuals with coronary atherosclerosis – The Swedish CArdioPulmonary BioImage Study Open
Background Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether non-imaging data, specificall…
View article: Automatic Time-resolved Multi-label Segmentation of the Aorta FBom 4D Flow CMR
Automatic Time-resolved Multi-label Segmentation of the Aorta FBom 4D Flow CMR Open
View article: Plasma Carotenoids are Inversely Correlated with Granulocyte Counts and Soluble Inflammatory Markers in a Swedish Middle-Aged Population: A Mediation Analysis
Plasma Carotenoids are Inversely Correlated with Granulocyte Counts and Soluble Inflammatory Markers in a Swedish Middle-Aged Population: A Mediation Analysis Open
View article: Abnormal Patterns of Wall Shear Stress in Aortic Dilation Revealed by Permutation Tests
Abnormal Patterns of Wall Shear Stress in Aortic Dilation Revealed by Permutation Tests Open
View article: Changes in natural killer and T lymphocyte phenotypes in response to cardiovascular risk management
Changes in natural killer and T lymphocyte phenotypes in response to cardiovascular risk management Open
View article: Hemodynamics and plasma biomarkers in individuals with mild-to-moderate ascending aortic dilatation and tricuspid aortic valves
Hemodynamics and plasma biomarkers in individuals with mild-to-moderate ascending aortic dilatation and tricuspid aortic valves Open
Background Ascending aortic (AA) dilatation is a silent disease that requires frequent follow-up measurements of the AA diameter. Unfortunately, the AA diameter is an insufficient predictor of future growth and complications. Hemodynamic a…
View article: Plasma type I collagen α1 chain in relation to coronary artery disease: findings from a prospective population-based cohort and an acute myocardial infarction prospective cohort in Sweden
Plasma type I collagen α1 chain in relation to coronary artery disease: findings from a prospective population-based cohort and an acute myocardial infarction prospective cohort in Sweden Open
Objectives To investigate the association between type I collagen α1 chain (COL1α1) levels and coronary artery disease (CAD) by using absolute quantification in plasma. Also, to investigate the correlates of COL1α1 to clinical characterist…
View article: Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population
Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population Open
View article: Prevalence and determinants of dilated ascending aorta in a Swedish population: a case–control study
Prevalence and determinants of dilated ascending aorta in a Swedish population: a case–control study Open
Aims Dilation of the ascending aorta (AA) is often asymptomatic until a life-threatening dissection or rupture occurs. An overall increase in the use of thoracic imaging has enabled early and sometimes incidental identification of AA dilat…
View article: Neutrophil activation status and low-density neutrophil fractions in patients with coronary artery disease
Neutrophil activation status and low-density neutrophil fractions in patients with coronary artery disease Open
View article: Sustained inflammation and high cortisol reactivity following an coronary event
Sustained inflammation and high cortisol reactivity following an coronary event Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Heart and lung foundation Sweden. Background Over the last decades, significant improvements have been made in medical and lifestyle managements of patie…
View article: The Effects of Dairy and Plant-Based Liquid Components on Lutein Liberation in Spinach Smoothies
The Effects of Dairy and Plant-Based Liquid Components on Lutein Liberation in Spinach Smoothies Open
Lutein is a dietary lipophilic compound with anti-inflammatory properties. We have previously shown that dairy fat can improve the lutein content in spinach smoothies. It is, however, unclear whether fat concentrations and fermentation sta…
View article: Complete fatty degeneration of thymus associates with male sex, obesity and immunological aging in a Swedish middle-aged population
Complete fatty degeneration of thymus associates with male sex, obesity and immunological aging in a Swedish middle-aged population Open
Background Fatty degeneration of thymus (or thymus involution) has long been considered a normal ageing process and the role of thymus in adults has drawn little attention. However, there is emerging evidence that thymic involution is link…
View article: Investigation of type 1 collagen a1 chain in plasma as a potential novel biomarker for prediction of coronary heart disease
Investigation of type 1 collagen a1 chain in plasma as a potential novel biomarker for prediction of coronary heart disease Open
Background Remodeling of the extracellular matrix (ECM) plays a crucial role in development and progression of atherosclerosis. Collagens, in particular type I collagen, are the most abundant ECM proteins in an atherosclerotic plaque. Rece…
View article: Differences in plasma lipoprotein profiles between patients with chronic peripheral neuropathic pain and healthy controls: an exploratory pilot study
Differences in plasma lipoprotein profiles between patients with chronic peripheral neuropathic pain and healthy controls: an exploratory pilot study Open
Introduction: Little is still known about the underlying mechanisms that drive and maintain neuropathic pain (NeuP). Recently, lipids have been implicated as endogenous proalgesic ligands affecting onset and maintenance of pain; however, i…
View article: Nationwide observational study of incidence, management and outcome of spontaneous coronary artery dissection: a report from the Swedish Coronary Angiography and Angioplasty register
Nationwide observational study of incidence, management and outcome of spontaneous coronary artery dissection: a report from the Swedish Coronary Angiography and Angioplasty register Open
Objectives The aim of this study was to conduct a nationwide all comer description of incidence, contemporary management and outcome in Swedish spontaneous coronary artery dissection (SCAD) patients. The incidence of SCAD as well as the ma…
View article: Mindfulness-Based Stress Reduction for Coronary Artery Disease Patients: Potential Improvements in Mastery and Depressive Symptoms
Mindfulness-Based Stress Reduction for Coronary Artery Disease Patients: Potential Improvements in Mastery and Depressive Symptoms Open
Depressive symptoms after coronary events are associated with a worse prognosis. When changing the focus from psychopathology towards a resilience framework, treatments such as mindfulness meditation could offer novel ways to address psych…
View article: Oxidative stress response in regulatory and conventional T cells: a comparison between patients with chronic coronary syndrome and healthy subjects
Oxidative stress response in regulatory and conventional T cells: a comparison between patients with chronic coronary syndrome and healthy subjects Open
View article: The effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease
The effect of acute exercise on interleukin-6 and hypothalamic–pituitary–adrenal axis responses in patients with coronary artery disease Open
View article: Oxidative Stress Response in Regulatory and Conventional T Cells: A Comparison Between Patients with Chronic Coronary Syndrome and Healthy Subjects
Oxidative Stress Response in Regulatory and Conventional T Cells: A Comparison Between Patients with Chronic Coronary Syndrome and Healthy Subjects Open
BackgroundInflammation and oxidative stress form a vicious circle in atherosclerosis. Oxidative stress can have detrimental effects on T cells. A unique subset of CD4 + T cells, known as regulatory T (T reg ) cells, has been associated wit…
View article: Collagen remodeling markers show differentiated expression in patients with ST- and non-ST elevation myocardial infarction
Collagen remodeling markers show differentiated expression in patients with ST- and non-ST elevation myocardial infarction Open
Background Following acute myocardial infarction (MI), the left ventricle undergoes molecular and extracellular matrix (ECM) changes. The ECM is a dynamic structure with a potential role in cardiac remodeling post-MI. Collagens are the maj…
View article: Spontaneous coronary artery dissection – contemporary management and outcome of a national cohort
Spontaneous coronary artery dissection – contemporary management and outcome of a national cohort Open
Background Spontaneous coronary artery dissection (SCAD) is proposed to cause 1–4% of all acute myocardial infarctions (AMI). The aim of this study was to conduct a first description of Swedish SCAD patients regarding the prevalence of ris…
View article: Sex differences in platelet reactivity in patients with myocardial infarction treated with triple antiplatelet therapy - results from assessing platelet activity in coronary heart disease (APACHE)
Sex differences in platelet reactivity in patients with myocardial infarction treated with triple antiplatelet therapy - results from assessing platelet activity in coronary heart disease (APACHE) Open
)Several earlier studies have reported increased risk of bleeding in women with myocardial infarction, (MI) compared to men. The reasons for the observed difference are incompletely understood, but one suggested explanation has been excess…
View article: Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome
Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome Open
Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cel…
View article: Salivary and plasma levels of matrix metalloproteinase-9 and myeloperoxidase at rest and after acute physical exercise in patients with coronary artery disease
Salivary and plasma levels of matrix metalloproteinase-9 and myeloperoxidase at rest and after acute physical exercise in patients with coronary artery disease Open
We conclude that salivary diagnostics cannot be used to assess systemic levels of MMP-9 and MPO in CAD patients, neither at rest nor after acute physical exercise.