Lenard Conradi
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View article: Peptidylarginine deiminase 4 deficiency alleviates hypoxia/reoxygenation-induced cardiomyocyte injury
Peptidylarginine deiminase 4 deficiency alleviates hypoxia/reoxygenation-induced cardiomyocyte injury Open
Background Cardiac ischemia reperfusion (I/R) injury is a serious consequence of reperfusion therapy for myocardial infarction (MI). Peptidylarginine deiminase 4 (PAD4) is a calcium-dependent enzyme that catalyzes the citrullination of pro…
View article: 2025 ESC/EACTS Guidelines for the management of valvular heart disease
2025 ESC/EACTS Guidelines for the management of valvular heart disease Open
International audience
View article: Preoperative Mechanical Ventilation Prior to Surgical Repair for Type A Aortic Dissection: Incidence, Risk, and Outcomes
Preoperative Mechanical Ventilation Prior to Surgical Repair for Type A Aortic Dissection: Incidence, Risk, and Outcomes Open
Objectives: Several conditions associated with type A aortic dissection may require preoperative invasive mechanical ventilation (IMV). The current literature lacks data on this subset of patients’ prevalence and postoperative outcomes. Th…
View article: An Imaging-Based Marker to Refine Risk Stratification for Transcatheter Mitral Valve Replacement
An Imaging-Based Marker to Refine Risk Stratification for Transcatheter Mitral Valve Replacement Open
Background: The Tendyne™ transcatheter heart valve (THV) system is a promising option for high-risk patients with severe mitral regurgitation (MR) who are ineligible for surgery or transcatheter edge-to-edge repair (TEER). As most fatal co…
View article: Clinical and health status after permanent pacemaker implantation in patients undergoing transcatheter aortic valve replacement: Insights from the SCOPE I randomized trial
Clinical and health status after permanent pacemaker implantation in patients undergoing transcatheter aortic valve replacement: Insights from the SCOPE I randomized trial Open
In the SCOPE I trial, new PPM implantation complicating TAVR had no impact on an integrated endpoint of vital and disease-specific health status throughout 3 years of follow-up.
View article: 72169 | Transcatheter Mitral Valve Replacement in Atrial and Ventricular Secondary Mitral Regurgitation: Insights From the CHOICE-MI Registry
72169 | Transcatheter Mitral Valve Replacement in Atrial and Ventricular Secondary Mitral Regurgitation: Insights From the CHOICE-MI Registry Open
View article: 72133 | Annular Dimensions Predict Cardiac Death in Transcatheter Mitral Valve Replacement
72133 | Annular Dimensions Predict Cardiac Death in Transcatheter Mitral Valve Replacement Open
View article: Mitral valve surgery after failed transcatheter intervention for mitral regurgitation: surgical techniques, challenges and outcomes
Mitral valve surgery after failed transcatheter intervention for mitral regurgitation: surgical techniques, challenges and outcomes Open
OBJECTIVES This review article aims to examine the surgical approach to patients with failed mitral transcatheter edge-to-edge repair (M-TEER), focusing on operative challenges, decision-making and contemporary outcome data. Technical cons…
View article: Extent of surgical repair and outcomes after surgery for type A aortic dissection
Extent of surgical repair and outcomes after surgery for type A aortic dissection Open
Background Acute Stanford type A aortic dissection is a severe emergency condition that, if left untreated, is associated with a high mortality rate. The extent of surgical repair may impact the outcomes of these patients. Method Patients …
View article: Apical Access Management in Transapical Transcatheter Mitral Valve Replacement
Apical Access Management in Transapical Transcatheter Mitral Valve Replacement Open
Access complications in transapical mitral valve replacement are relatively rare but associated with poor short-term outcome. Focus on the apical myocardium within the screening process and specific surgical training might avoid AACs and i…
View article: The Impact of Frailty on VARC-3 Integrated Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement
The Impact of Frailty on VARC-3 Integrated Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement Open
More than 1 in 6 patients with severe aortic stenosis undergoing TAVR were considered frail in the SCOPE I trial. Patients with frailty had a similar improvement in patient-reported health status measures after TAVR, but a higher risk of u…
View article: Evolution of Endoscopic Mitral Valve Surgery Over a 11-Year Period at a High-Volume Center
Evolution of Endoscopic Mitral Valve Surgery Over a 11-Year Period at a High-Volume Center Open
View article: TransCatheter aortic valve implantation and fractional flow reserve-guided percutaneous coronary intervention versus conventional surgical aortic valve replacement and coronary bypass grafting for treatment of patients with aortic valve stenosis and complex or multivessel coronary disease (TCW): an international, multicentre, prospective, open-label, non-inferiority, randomised controlled trial
TransCatheter aortic valve implantation and fractional flow reserve-guided percutaneous coronary intervention versus conventional surgical aortic valve replacement and coronary bypass grafting for treatment of patients with aortic valve stenosis and complex or multivessel coronary disease (TCW): an international, multicentre, prospective, open-label, non-inferiority, randomised controlled trial Open
View article: Femoral or Radial Secondary Access in TAVR
Femoral or Radial Secondary Access in TAVR Open
During transfemoral TAVR, TR-SA was associated with lower rates of access site complications and severe bleeding compared to TF-SA. In fact, secondary access-related complications were 10× higher for TF-SA and frequently required invasive …
View article: The David Versus the Bentall Procedure for Acute Type A Aortic Dissection
The David Versus the Bentall Procedure for Acute Type A Aortic Dissection Open
Background: Type A aortic dissection (TAAD) is a life-threatening condition which requires prompt diagnosis and surgical treatment. When TAAD involves the aortic root, aortic valve-sparing or Bentall procedures are the main surgical treatm…
View article: Malperfusion syndrome in patients undergoing repair for acute type A aortic dissection: Presentation, mortality, and utility of the Penn classification
Malperfusion syndrome in patients undergoing repair for acute type A aortic dissection: Presentation, mortality, and utility of the Penn classification Open
Nearly one half of the examined cohort presented with signs of malperfusion syndrome predominantly attributable to local involvement. More than one third of patients with local malperfusion syndrome had a multivessel involvement. Furthermo…
View article: Five-year outcomes of transcatheter aortic valve implantation with the ACURATE neo2 valve system
Five-year outcomes of transcatheter aortic valve implantation with the ACURATE neo2 valve system Open
View article: Incidence and Outcomes of Emergency Intraprocedural Surgical Conversion During Transcatheter Aortic Valve Implantation: A Multicentric Analysis
Incidence and Outcomes of Emergency Intraprocedural Surgical Conversion During Transcatheter Aortic Valve Implantation: A Multicentric Analysis Open
View article: Role of gender in short- and long-term outcomes after surgery for type A aortic dissection: analysis of a multicentre European registry
Role of gender in short- and long-term outcomes after surgery for type A aortic dissection: analysis of a multicentre European registry Open
OBJECTIVES Gender difference in the outcome after type A aortic dissection (TAAD) surgery remains an issue of ongoing debate. In this study, we aimed to evaluate the impact of gender on the short- and long-term outcome after surgery for TA…
View article: Left and Right Ventricular Hemodynamic Response After Transcatheter Mitral Valve Replacement
Left and Right Ventricular Hemodynamic Response After Transcatheter Mitral Valve Replacement Open
View article: Leaflet modification before transcatheter aortic valve implantation in patients at risk for coronary obstruction: the ShortCut study
Leaflet modification before transcatheter aortic valve implantation in patients at risk for coronary obstruction: the ShortCut study Open
Background and Aims This trial sought to assess the safety and efficacy of ShortCut, the first dedicated leaflet modification device, prior to transcatheter aortic valve implantation (TAVI) in patients at risk for coronary artery obstructi…
View article: Transcatheter aortic valve implantation in patients with significant septal hypertrophy
Transcatheter aortic valve implantation in patients with significant septal hypertrophy Open
Background Previous reports suggest septal hypertrophy with an interventricular septum depth (IVSD) ≥ 14 mm may adversely affect outcomes after transcatheter aortic valve implantation (TAVI) due to suboptimal valve placement, valve migrati…
View article: Intravascular Lithotripsy-Assisted Transfemoral Transcatheter Aortic Valve Implantation in Patients with Severe Iliofemoral Calcifications: Expanding Transfemoral Indications
Intravascular Lithotripsy-Assisted Transfemoral Transcatheter Aortic Valve Implantation in Patients with Severe Iliofemoral Calcifications: Expanding Transfemoral Indications Open
(1) Background: Transfemoral transcatheter aortic valve implantation (TAVI) has become the standard treatment for most patients with severe symptomatic aortic stenosis. Intravascular lithotripsy may facilitate transfemoral TAVI (IVL-TAVI) …
View article: Transapical Mitral Valve Replacement
Transapical Mitral Valve Replacement Open
This large, real-world, observational registry reports high technical success, durable and complete MR elimination, significant clinical benefits, and a 1-year cardiovascular mortality rate of 17% after Tendyne TMVR. Outcomes were comparab…
View article: TransCatheter aortic valve implantation and fractional flow reserve-guided percutaneous coronary intervention versus conventional surgical aortic valve replacement and coronary bypass grafting for treatment of patients with aortic valve stenosis and multivessel or advanced coronary disease: The transcatheter valve and vessels trial (TCW trial): Design and rationale
TransCatheter aortic valve implantation and fractional flow reserve-guided percutaneous coronary intervention versus conventional surgical aortic valve replacement and coronary bypass grafting for treatment of patients with aortic valve stenosis and multivessel or advanced coronary disease: The transcatheter valve and vessels trial (TCW trial): Design and rationale Open
View article: Baseline risk factors of in-hospital mortality after surgery for acute type A aortic dissection: an ERTAAD study
Baseline risk factors of in-hospital mortality after surgery for acute type A aortic dissection: an ERTAAD study Open
Background Surgery for type A aortic dissection (TAAD) is associated with high risk of mortality. Current risk scoring methods have a limited predictive accuracy. Methods Subjects were patients who underwent surgery for acute TAAD at 18 Eu…
View article: Impact of transcatheter heart valve type on outcomes of surgical explantation after failed transcatheter aortic valve replacement: the EXPLANT-TAVR international registry
Impact of transcatheter heart valve type on outcomes of surgical explantation after failed transcatheter aortic valve replacement: the EXPLANT-TAVR international registry Open
In the EXPLANT-TAVR global registry, BEV and SEV groups had different indications for surgical explantation, with more root replacements in SEV failure, but no differences in midterm mortality and morbidities. Further refinement of TAVR ex…
View article: Early outcome of endoscopic mitral valve surgery in elderly patients: a high-volume single center experience
Early outcome of endoscopic mitral valve surgery in elderly patients: a high-volume single center experience Open
Introduction Despite increasing use of transcatheter approaches, endoscopic mitral valve surgery (MVS) remains an established option for treatment of mitral regurgitation (MR). Nevertheless, as perioperative risk increases with age, outcom…
View article: Valve Hemodynamics by Valve Size and 1-Year Survival Following Implantation of the Portico Valve in the Multicenter CONFIDENCE Registry
Valve Hemodynamics by Valve Size and 1-Year Survival Following Implantation of the Portico Valve in the Multicenter CONFIDENCE Registry Open
View article: Impact of anaemia and iron deficiency on long-term outcomes following transcatheter edge-to-edge repair in degenerative vs. secondary mitral regurgitation: results from a large single-center study
Impact of anaemia and iron deficiency on long-term outcomes following transcatheter edge-to-edge repair in degenerative vs. secondary mitral regurgitation: results from a large single-center study Open
Background Transcatheter mitral valve edge-to-edge repair (TEER) is an established therapeutic option for significant mitral regurgitation (MR), as an alternative for patients at high risk for open heart surgery. While mitral valve reconst…