Lene Holmvang
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View article: Impact of extended eligibility criteria on survival after veno-arterial extracorporeal membrane oxygenation for refractory cardiac arrest: a 8-year single-center study
Impact of extended eligibility criteria on survival after veno-arterial extracorporeal membrane oxygenation for refractory cardiac arrest: a 8-year single-center study Open
Aim: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) may improve survival in refractory in- or out-of-hospital cardiac arrest (IHCA/OHCA), yet optimal selection criteria remain uncertain. We aimed to report contemporary surviva…
View article: Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock
Systolic Blood Pressure and Microaxial Flow Pump–Associated Survival in Infarct-Related Cardiogenic Shock Open
Importance Microaxial flow pump treatment improves survival in selected patients with infarct-related cardiogenic shock; however, treatment carries substantial risks, and benefit may vary by patient subgroup. Systolic blood pressure (SBP) …
View article: Exploring the Role of Cardiac Troponin-Specific Autoantibodies: Prolonged Cardiac Troponin Elimination, Reduced Clearance, and Variable Interference across 5 Commercial Assays
Exploring the Role of Cardiac Troponin-Specific Autoantibodies: Prolonged Cardiac Troponin Elimination, Reduced Clearance, and Variable Interference across 5 Commercial Assays Open
Background High-sensitivity cardiac troponin (hs-cTn) assays are prone to negative and positive interferences caused by endogenous cardiac troponin-specific autoantibodies (cTnAAbs). Large macrotroponin complexes formed of cardiac troponin…
View article: Left Ventricular Ejection Fraction Reserve and Its Association with Myocardial Perfusion, Coronary Calcification, and Strain in Type 2 Diabetes Without Overt Cardiovascular Disease
Left Ventricular Ejection Fraction Reserve and Its Association with Myocardial Perfusion, Coronary Calcification, and Strain in Type 2 Diabetes Without Overt Cardiovascular Disease Open
Background: Type 2 diabetes (T2D) is a major risk factor for cardiovascular disease (CVD), but the relationships between myocardial function, microvascular function, and atherosclerotic burden remain underexplored in asymptomatic individua…
View article: 10-Year Outcomes of Deferred or Conventional Stent Implantation in Patients With STEMI (DANAMI-3-DEFER)
10-Year Outcomes of Deferred or Conventional Stent Implantation in Patients With STEMI (DANAMI-3-DEFER) Open
BACKGROUND: Primary percutaneous coronary intervention (PCI) with stenting is recommended in ST-segment–elevation myocardial infarction. Immediate stenting may cause distal embolization, microvascular damage, and flow disturbances, leading…
View article: Prognostic impact of cardiac dysfunction in patients with ST-segment elevation myocardial infarction
Prognostic impact of cardiac dysfunction in patients with ST-segment elevation myocardial infarction Open
Background The incidence and impact of systolic and diastolic dysfunction after ST-segment elevation myocardial infarction (STEMI) are not completely understood. Purpose In patients with STEMI treated with primary percutaneous coronary int…
View article: Sex differences based on the timing of invasive management among patients with non-ST-elevation acute coronary syndrome: an individual patient data meta-analysis
Sex differences based on the timing of invasive management among patients with non-ST-elevation acute coronary syndrome: an individual patient data meta-analysis Open
Aims Studies investigating the timing of coronary angiography in non-ST-elevation acute coronary syndrome (NSTE-ACS) have not evaluated sex differences. This study aims to investigate the sex-related differences in outcomes of NSTE-ACS pat…
View article: Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study
Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study Open
In individuals with type 2 diabetes without overt CVD, women exhibited lower MFR than men, primarily due to higher MBF at rest, suggesting sex-related differences. While MFR declined in both sexes, the sex difference was more pronounced in…
View article: Coronary angiography and percutaneous coronary intervention in frail patients over 70 years old with acute coronary syndrome referred for invasive treatment
Coronary angiography and percutaneous coronary intervention in frail patients over 70 years old with acute coronary syndrome referred for invasive treatment Open
Background Studies have shown that frailty is associated with worse outcome in older patients with acute coronary syndrome (ACS). However, findings related to the coronary angiography (CAG) and outcome related to the level of revasculariza…
View article: Neurohormonal response is associated with mortality in women with ST-elevation myocardial infarction
Neurohormonal response is associated with mortality in women with ST-elevation myocardial infarction Open
Aims Women continue to have a worse prognosis following ST-elevation myocardial infarction (STEMI) compared to men, despite advancements in treatment. This study investigates whether neurohormonal biomarker differences contribute to sex-re…
View article: Microaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial
Microaxial Flow Pump Use and Renal Outcomes in Infarct-Related Cardiogenic Shock: A Secondary Analysis of the DanGer Shock Trial Open
BACKGROUND: In DanGer Shock (the Danish–German Cardiogenic Shock trial), use of a microaxial flow pump (mAFP) in patients with ST-segment–elevation myocardial infarction–related cardiogenic shock led to lower all-cause mortality but higher…
View article: Acute echocardiographic assessment of patients with ST-elevation myocardial infarction in detecting clinically hidden hemodynamic deterioration
Acute echocardiographic assessment of patients with ST-elevation myocardial infarction in detecting clinically hidden hemodynamic deterioration Open
Background Transthoracic echocardiography (TTE) offers an immediate non-invasive assessment of cardiac morphology and function that can be performed bedside. Acute TTE in the catheterization laboratory (cath.lab.) may be helpful to identif…
View article: Implementation of prasugrel and prognostic outcomes after percutaneous coronary intervention for myocardial infarction: a nationwide observational study
Implementation of prasugrel and prognostic outcomes after percutaneous coronary intervention for myocardial infarction: a nationwide observational study Open
Background Prasugrel has shown superior efficacy and similar safety compared to ticagrelor for patients with acute coronary syndrome treated with percutaneous coronary intervention (PCI) in a randomised setting. Since 2020, prasugrel has b…
View article: Half-Life and Clearance of Cardiac Troponin I and Troponin T in Humans
Half-Life and Clearance of Cardiac Troponin I and Troponin T in Humans Open
BACKGROUND: Cardiac troponin (cTn) is key in diagnosing myocardial infarction (MI). After MI, the clinically observed half-life of cTn has been reported to be 7 to 20 hours, but this estimate reflects the combined elimination and simultane…
View article: Prehospital Pulse-Dose Glucocorticoid in ST-Segment Elevation Myocardial Infarction
Prehospital Pulse-Dose Glucocorticoid in ST-Segment Elevation Myocardial Infarction Open
Importance In patients with ST-segment elevation myocardial infarction (STEMI), acute inflammation is related to the extent of myocardial damage and may increase infarct size. Thus, administration of pulse-dose glucocorticoid in the very e…
View article: DANSPOT: A Multicenter Stepped‐Wedge Cluster‐Randomized Trial of the Reclassification of Acute Myocardial Infarction: Rationale and Study Design
DANSPOT: A Multicenter Stepped‐Wedge Cluster‐Randomized Trial of the Reclassification of Acute Myocardial Infarction: Rationale and Study Design Open
Background Cardiac troponins are the preferred biomarkers for the diagnosis of acute myocardial infarction. Although sex‐specific 99th percentile thresholds of troponins are recommended in international guidelines, the clinical effect of t…
View article: Admission plasma concentration of neutrophil gelatinase-associated lipocalin and -C-reactive protein have additive prognostic value in patients with STEMI
Admission plasma concentration of neutrophil gelatinase-associated lipocalin and -C-reactive protein have additive prognostic value in patients with STEMI Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): This work was supported by Righospitalets Forskningsfond (07IO) Lundbeck Foundation (R186-2015-2132). Background Inflammation plays an apparent critical …
View article: Risk assessment by acute bedside echocardiography prior to acute coronary angiography in patients with ST-elevation myocardial infarction: a feasibility study
Risk assessment by acute bedside echocardiography prior to acute coronary angiography in patients with ST-elevation myocardial infarction: a feasibility study Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Novo Nordisk Foundation. Background Early risk assessment by hemodynamic measurements in patients with ST-elevation myocardial infarction (STEMI) could b…
View article: Psychotropic medication use and mortality in patients with acute myocardial infarction complicated by cardiogenic shock
Psychotropic medication use and mortality in patients with acute myocardial infarction complicated by cardiogenic shock Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): The Danish Heart Foundation the Research Foundation of Odense University Hospital & Rigshospitalet. Background The impact of pre-existing mental illness …
View article: Return to Work After Refractory Out‐of‐Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register‐Based Study
Return to Work After Refractory Out‐of‐Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register‐Based Study Open
Background Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory out‐of‐hospital cardiac arrest (OHCA). However, survivors managed with ECPR are at risk of poor functional status. The purpose of this study…
View article: Management of cardiac emergencies in women: a clinical consensus statement of the Association for Acute CardioVascular Care (ACVC), the European Association of Percutaneous Cardiovascular Interventions (EAPCI), the Heart Failure Association (HFA), and the European Heart Rhythm Association (EHRA) of the ESC, and the ESC Working Group on Cardiovascular Pharmacotherapy
Management of cardiac emergencies in women: a clinical consensus statement of the Association for Acute CardioVascular Care (ACVC), the European Association of Percutaneous Cardiovascular Interventions (EAPCI), the Heart Failure Association (HFA), and the European Heart Rhythm Association (EHRA) of the ESC, and the ESC Working Group on Cardiovascular Pharmacotherapy Open
Cardiac emergencies in women, such as acute coronary syndromes, acute heart failure, and cardiac arrest, are associated with a high risk of adverse outcomes and mortality. Although women historically have been significantly underrepresente…
View article: The importance of nonobstructive plaque characteristics in symptomatic and asymptomatic coronary artery disease
The importance of nonobstructive plaque characteristics in symptomatic and asymptomatic coronary artery disease Open
Nonobstructive CAD was the predominant contributor to total atherosclerotic plaque volume in both subclinical and clinically manifested CAD. Nonobstructive fibrous, fibrofatty and necrotic core tissue volumes increased with worsening clini…
View article: Organized thrombus is a frequent underlying feature in culprit lesion morphology in non-ST-elevation myocardial infarction. A study using optical coherence tomography and magnetic resonance imaging
Organized thrombus is a frequent underlying feature in culprit lesion morphology in non-ST-elevation myocardial infarction. A study using optical coherence tomography and magnetic resonance imaging Open
The concept that the culprit lesion in non-ST segment elevation myocardial infarction (NSTEMI) is caused by sudden plaque rupture with acute thrombus formation has recently been challenged. While angiography is an old gold-standard for cul…
View article: Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable-polymer coronary stent – five-year results of the TARGET All Comers randomised clinical trial
Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable-polymer coronary stent – five-year results of the TARGET All Comers randomised clinical trial Open
In an all-comers population requiring stent implantation for myocardial ischaemia, the BP-SES was non-inferior to the DP-EES for the primary endpoint of TLF at 12 months, and results were sustained at 5 years, confirming the long-term safe…
View article: Increased Subclinical Coronary Artery Pathology in Type 2 Diabetes With Albuminuria
Increased Subclinical Coronary Artery Pathology in Type 2 Diabetes With Albuminuria Open
Diabetes affects the kidneys, and the presence of albuminuria reflects widespread vascular damage and is a risk factor for cardiovascular disease (CVD). Still, the pathophysiological association between albuminuria and CVD remains incomple…
View article: Increased sub-clinical coronary artery pathology in type 2 diabetes with albuminuria.
Increased sub-clinical coronary artery pathology in type 2 diabetes with albuminuria. Open
Diabetes affects the kidneys, and presence of albuminuria reflects widespread vascular damage and is a risk factor for cardiovascular disease (CVD). Still, the pathophysiological association between albuminuria and CVD remains incompletely…
View article: Increased sub-clinical coronary artery pathology in type 2 diabetes with albuminuria.
Increased sub-clinical coronary artery pathology in type 2 diabetes with albuminuria. Open
Diabetes affects the kidneys, and presence of albuminuria reflects widespread vascular damage and is a risk factor for cardiovascular disease (CVD). Still, the pathophysiological association between albuminuria and CVD remains incompletely…