Lengxi Fu
YOU?
Author Swipe
View article: PNMA5 Promotes Bone Metastasis of Non-small-Cell Lung Cancer as a Target of BMP2 Signaling
PNMA5 Promotes Bone Metastasis of Non-small-Cell Lung Cancer as a Target of BMP2 Signaling Open
Bone metastases frequently occur in NSCLC patients at the late stage, indicating poor survival. However, mechanisms about the initiation of NSCLC bone metastases remain largely unclear. In our previous reports, BMP2 signaling activation ha…
View article: Irradiated whole‑cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells
Irradiated whole‑cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells Open
Liver cancer is one of the most common malignant tumors with no available satisfactory treatment. The aim of the present study was to investigate the anti-tumor effect of an irradiated hepatocellular carcinoma (HCC) whole-cell vaccine and …
View article: BMP2 signalling activation enhances bone metastases of non‐small cell lung cancer
BMP2 signalling activation enhances bone metastases of non‐small cell lung cancer Open
Distant metastases occur when non‐small cell lung cancer (NSCLC) is at late stages. Bone metastasis is one of the most frequent metastases of NSCLC and leads to poor prognosis. It has been reported that high expression of BMP2 in NSCLC cor…
View article: Autophagy mediates bronchial cell malignant transformation induced by chronic arsenic exposure via MEK/ERK1/2 pathway
Autophagy mediates bronchial cell malignant transformation induced by chronic arsenic exposure via MEK/ERK1/2 pathway Open
Chronic exposure to arsenic increases the risk of developing a variety of human cancers including lung carcinomas. However, the exact molecular mechanism underlying arsenic carcinogenicity remains largely unknown. Autophagy is a conserved …
View article: Hypofractionated Irradiation Suppressed the Off-Target Mouse Hepatocarcinoma Growth by Inhibiting Myeloid-Derived Suppressor Cell-Mediated Immune Suppression
Hypofractionated Irradiation Suppressed the Off-Target Mouse Hepatocarcinoma Growth by Inhibiting Myeloid-Derived Suppressor Cell-Mediated Immune Suppression Open
Background: Stereotactic radiotherapy treats hepatocellular carcinoma (HCC) at different stages effectively and safely. Besides its direct killing of cancer cells, radiotherapy stimulates host immunity against hepatoma. However, the role o…
View article: BMP2 Signaling Activation Enhances Bone Metastases of None-small-cell Lung Cancer
BMP2 Signaling Activation Enhances Bone Metastases of None-small-cell Lung Cancer Open
Background: Distant metastases occur when none-small-cell lung cancer (NSCLC) is at late stages. Bone metastasis is one of the most frequent metastases of NSCLC and leads to poor prognosis. It has been reported that high expression of BMP2…
View article: Proposed revision of the 8th edition AJCC clinical staging system for esophageal squamous cell cancer treated with definitive chemo-IMRT based on CT imaging
Proposed revision of the 8th edition AJCC clinical staging system for esophageal squamous cell cancer treated with definitive chemo-IMRT based on CT imaging Open
The SLNM should be dealt with as a regional rather than a distant disease in patients with ESCC when treated with CRT. The proposed nonsurgical staging system based on the GTV-prT and N appears to be a simple and accurate prognosis predict…
View article: <b>δ</b>-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8<sup>+</sup> T cell activation
<b>δ</b>-Catenin peptide vaccines repress hepatocellular carcinoma growth via CD8<sup>+</sup> T cell activation Open
As classical therapy method of advanced hepatocellular carcinoma (HCC) is not effective enough, HCC immunotherapy is a hot spot for research in recent years. Although in recent years, immune checkpoint inhibitors are focused in cancer ther…
View article: DcR3, a new biomarker for sepsis, correlates with infection severity and procalcitonin
DcR3, a new biomarker for sepsis, correlates with infection severity and procalcitonin Open
Early diagnosis of sepsis is critical for successful treatment. The clinical value of DcR3 in early diagnosis of sepsis was determined in a dynamic follow-up study. Alterations in plasma levels of DcR3, PCT, CRP, and IL-6 were measured by …
View article: δ-Catenin promotes tumorigenesis and metastasis of lung adenocarcinoma
δ-Catenin promotes tumorigenesis and metastasis of lung adenocarcinoma Open
δ-Catenin coded by gene CTNND2 has been found to be overexpressed in various types of cancers, including prostate, breast, lung and ovarian cancers. However, the function of δ-catenin in lung carcinoma remains largely unknown. In the prese…
View article: Comparison of three different methods for the detection of circulating tumor cells in mice with lung metastasis
Comparison of three different methods for the detection of circulating tumor cells in mice with lung metastasis Open
Circulating tumor cells (CTCs) represent the key step of cancer cell dissemination. The alteration of CTCs correlates with the treatment outcome and prognosis. To enrich and identify CTCs from billions of blood cells renders a very challen…