Lenka Lorencová
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Glycoproteomics of Gastrointestinal Cancers and Its Use in Clinical Diagnostics Open
Cancer is a leading cause of death worldwide, resulting in substantial economic costs. Because cancer is a complex, heterogeneous group of diseases affecting a variety of cells, its detection may sometimes be difficult. Herein we review a …
Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes Open
Herein, the basic properties, composition, and isolation methods for the separation of exosomes are described, since they can be a rich source of disease biomarkers. Then an introduction to MXenes, a novel class of 2D nanomaterials with in…
Advances in magnetic affinity-based isolation/detection of exosomes for robust diagnostics Open
The review article provides a short introduction to exosomes with the focus to use exosomes as disease markers itself (i.e. their concentration or presence of some specific receptors) or a source of disease biomarkers such as proteins and …
Direct electron transfer and direct bioelectrocatalysis of sarcosine oxidase on Ti3C2Tx MXene hybrid interface Open
The current study shows a direct electron transfer (DET) and direct bioelectrocatalysis of the sarcosine oxidase (SOx) on the screen-printed carbon electrode (SPCE) modified by a hybrid bionanocomposite composed of chitosan (CS) and Ti 3 C…
Medical Relevance, State-of-the-Art and Perspectives of “Sweet Metacode” in Liquid Biopsy Approaches Open
This review briefly introduces readers to an area where glycomics meets modern oncodiagnostics with a focus on the analysis of sialic acid (Neu5Ac)-terminated structures. We present the biochemical perspective of aberrant sialylation durin…
Negative Charge-Carrying Glycans Attached to Exosomes as Novel Liquid Biopsy Marker Open
Prostate cancer (PCa) is the second most common cancer. In this paper, the isolation and properties of exosomes as potential novel liquid biopsy markers for early PCa liquid biopsy diagnosis are investigated using two prostate human cell l…
A Holistic 4D Approach to Optimize Intrinsic and Extrinsic Factors Contributing to Variability in Microarray Biosensing in Glycomics Open
Protein–carbohydrate interactions happen to be a crucial facet of biology, discharging a myriad of functions. Microarrays have become a premier choice to discern the selectivity, sensitivity and breadth of these interactions in a high-thro…
Amperometric Miniaturised Portable Enzymatic Nanobiosensor for the Ultrasensitive Analysis of a Prostate Cancer Biomarker Open
Screen-printing technology is a game changer in many fields including electrochemical biosensing. Two-dimensional nanomaterial MXene Ti3C2Tx was integrated as a nanoplatform to immobilise enzyme sarcosine oxidase (SOx) onto the interface o…
Novel Prostate Cancer Biomarkers: Aetiology, Clinical Performance and Sensing Applications Open
The review initially provides a short introduction to prostate cancer (PCa) incidence, mortality, and diagnostics. Next, the need for novel biomarkers for PCa diagnostics is briefly discussed. The core of the review provides details about …
Ti<sub>3</sub>C<sub>2</sub> MXene-Based Nanobiosensors for Detection of Cancer Biomarkers Open
This chapter provides information about basic properties of MXenes (2D nanomaterials) that are attractive for a design of various types of nanobiosensors. The second part of the chapter discusses MXene synthesis and various protocols for m…
screen-printed molybdenum disulfide electrodes for electrochemical sensing of dopamine Open
Two-dimensional (2D) molybdenum disulphide (MoS2) belongs to a class of materials called transition metal dichalcogenides (TMDCs).Due to its large surface area, high biocompatibility, non-zero band-gap, structural versatility and mechanica…
Electrochemical Impedance Spectroscopy on 2D Nanomaterial MXene Modified Interfaces: Application as a Characterization and Transducing Tool Open
This review presents the basic characteristics of MXene, a novel 2D nanomaterial with many outstanding properties applicable to electrochemical sensing and biosensing. The second part deals with electrochemical impedance spectroscopy (EIS)…
Validating fPSA Glycoprofile as a Prostate Cancer Biomarker to Avoid Unnecessary Biopsies and Re-Biopsies Open
Background: To compare the clinical performance of a new PCa serum biomarker based on fPSA glycoprofiling to fPSA% and PHI. Methods: Serum samples from men who underwent prostate biopsy due to increased PSA were used. A comparison between …
Electrochemical Investigation of Interfacial Properties of Ti3C2Tx MXene Modified by Aryldiazonium Betaine Derivatives Open
For efficient and effective utilization of MXene such as biosensing or advanced applications, interfacial modification of MXene needs to be considered. To this end, we describe modification of Ti3C2Tx MXene by aryldiazonium-based grafting …
Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers Open
This comprehensive review paper describes recent advances made in the field of electrochemical nanobiosensors for the detection of breast cancer (BC) biomarkers such as specific genes, microRNA, proteins, circulating tumor cells, BC cell l…
Ultrasensitive Ti3C2TX MXene/Chitosan Nanocomposite-Based Amperometric Biosensor for Detection of Potential Prostate Cancer Marker in Urine Samples Open
Two-dimensional layered nanomaterial Ti3C2TX (a member of the MXene family) was used to immobilise enzyme sarcosine oxidase to fabricate a nanostructured biosensor. The device was applied for detection of sarcosine, a potential prostate ca…
Exosomes as a Source of Cancer Biomarkers: Advances in Electrochemical Biosensing of Exosomes Open
Invited for this month's cover picture is the group of Dr. Jan Tkac (head of the Department of Glycobiotechnology at the Institute of Chemistry at the Slovak Academy of Sciences, Slovakia). The cover picture shows a common eukaryotic cell …
Front Cover: Exosomes as a Source of Cancer Biomarkers: Advances in Electrochemical Biosensing of Exosomes (ChemElectroChem 9/2020) Open
The Front Cover illustrates a common eukaryotic cell with basic organelles, as well as intracellular formation/preparation of exosomes for express delivery to distant tissues. More information can be found in the Review by L. Lorencova et …
A Graphene-Based Glycan Biosensor for Electrochemical Label-Free Detection of a Tumor-Associated Antibody Open
The study describes development of a glycan biosensor for detection of a tumor-associated antibody. The glycan biosensor is built on an electrochemically activated/oxidized graphene screen-printed electrode (GSPE). Oxygen functionalities w…
Cover Feature: 2D MXenes as Perspective Immobilization Platforms for Design of Electrochemical Nanobiosensors (Electroanalysis 10/2019) Open
2D MXenes as Perspective Immobilization Platforms for Design of Electrochemical Nanobiosensors. More details can be found in the Full Paper by Lenca Lorencova et al. (DOI: 10.1002/elan.201900288).
Prostate-specific antigen glycoprofiling as diagnostic and prognostic biomarker of prostate cancer Open
The initial part of this review details the controversy behind the use of a serological level of prostate-specific antigen (PSA) for the diagnostics of prostate cancer (PCa). Novel biomarkers are in demand for PCa diagnostics, outperformin…
Cover Feature: Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers (ChemElectroChem 4/2019) Open
The Cover Feature shows integration of electrochemical impedance spectroscopy for the analysis of clinically relevant samples toward cancer diagnostics. More information can be found in the Review by T. Bertok et al. on page 989 in Issue 4…
Tailoring Electrocatalytic Properties of Pt Nanoparticles Grown on Ti<sub>3</sub>C<sub>2</sub>T<sub>X</sub>MXene Surface Open
In this work, the spontaneous and NaBH4-induced reduction of chloroplatinic acid on the surface of Ti3C2TX MXene was investigated to synthesize a hybrid PtNP-decorated MXene nanomaterial (MX-Pt) with potential as hydrogen evolution (HER) o…