Lennart R. B. Spindler
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View article: Multimodal markers of immune activation predict cognitive outcomes in Parkinson’s disease
Multimodal markers of immune activation predict cognitive outcomes in Parkinson’s disease Open
An increase in activated CD4 cells in the blood, transition of B cells to the CNS and inflammation in the substantia nigra were predictive of longitudinal cognitive outcomes in PD. These markers warrant further validation as biomarkers for…
View article: A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's
A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's Open
There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene …
View article: A 14-year longitudinal study of neurofilament light chain dynamics in premanifest and transitional Huntington’s disease
A 14-year longitudinal study of neurofilament light chain dynamics in premanifest and transitional Huntington’s disease Open
View article: Neuroinflammation is linked to dementia risk in Parkinson’s disease
Neuroinflammation is linked to dementia risk in Parkinson’s disease Open
The development of dementia is a devastating aspect of Parkinson’s disease (PD), affecting nearly half of patients within 10 years post-diagnosis. For effective therapies to prevent and slow progression to PD dementia (PDD), the key mechan…
View article: Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury
Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury Open
Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and are difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI and may be related to long-term outcomes but requi…
View article: Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses
Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses Open
COVID-19 is associated with neurological complications including stroke, delirium and encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms is common, and is seemingly unrelated to COVID-19 severity. The t…
View article: Correction: Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science
Correction: Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science Open
wearable brain monitoring system for patient care.
View article: Network dynamics scale with levels of awareness
Network dynamics scale with levels of awareness Open
Small world topologies are thought to provide a valuable insight into human brain organisation and consciousness. However, functional magnetic resonance imaging studies in consciousness have not yielded consistent results. Given the import…
View article: Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study
Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study Open
Human coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has multiple neurological consequences, but its long-term effect on brain health is still uncertain. The cerebrovascular conseque…
View article: Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study
Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study Open
View article: Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation
Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation Open
Significance Understanding the neural bases of consciousness is of basic scientific and clinical importance. Human neuroimaging has established that a network of interconnected brain regions known as the default mode network disintegrates …
View article: Research data supporting "Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation"
Research data supporting "Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation" Open
These are the data that underpin all analyses and figures in the publication. \nThe Excel spreadsheet contains functional connectivity estimates (beta values) extracted from the general linear model (GLM) for both cohorts for the VTA to Pr…
View article: Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science
Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science Open
View article: Network dynamics scale with levels of awareness
Network dynamics scale with levels of awareness Open
Small world topologies are thought to provide a valuable insight into human brain organisation and consciousness. However, functional magnetic resonance imaging studies in consciousness have not yielded consistent results. Given the import…
View article: The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia
The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia Open
“Neural inertia” is the brain’s tendency to resist changes in its arousal state: it is manifested as emergence from anaesthesia occurring at lower drug doses than those required for anaesthetic induction, a phenomenon observed across very …
View article: Neuroanatomical substrates of generalized brain dysfunction in COVID-19
Neuroanatomical substrates of generalized brain dysfunction in COVID-19 Open
View article: Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors
Balanced cholinergic modulation of spinal locomotor circuits via M2 and M3 muscarinic receptors Open