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View article: A State-of-the-Art Overview on (Epi)Genomics and Personalized Skin Rejuvenating Strategies
A State-of-the-Art Overview on (Epi)Genomics and Personalized Skin Rejuvenating Strategies Open
This article aims to point out new perspectives opened by genomics and epigenomics in skin rejuvenation strategies which target the main hallmarks of the ageing. In this respect, this article presents a concise overview on: the clinical re…
View article: Niosomes as Vesicular Carriers: From Formulation Strategies to Stimuli-Responsive Innovative Modulations for Targeted Drug Delivery
Niosomes as Vesicular Carriers: From Formulation Strategies to Stimuli-Responsive Innovative Modulations for Targeted Drug Delivery Open
Niosomes (NIOs), a class of nanovesicular drug delivery system, have garnered significant attention due to their unique architecture, resulting from the self-assembly of non-ionic surfactants (with or without cholesterol) in aqueous media.…
View article: Heart Failure Biomarkers—Pathophysiology, Diagnosis, Prognosis and Clinical Relevance
Heart Failure Biomarkers—Pathophysiology, Diagnosis, Prognosis and Clinical Relevance Open
Heart failure (HF) is a complex clinical syndrome characterized by impaired cardiac function and maladaptive neurohormonal activation, representing one of the leading causes of morbidity, hospitalization, and mortality worldwide. Both its …
View article: Aptamer-Nanoconjugates as Potential Theranostics in Major Neuro-Oncological and Neurodegenerative Disorders
Aptamer-Nanoconjugates as Potential Theranostics in Major Neuro-Oncological and Neurodegenerative Disorders Open
This review aims to point out the main achievements in the cutting-edge field of aptamer nanotechnology and its applications in the most frequent neuro-oncological and neurodegenerative diseases. The article discusses the properties, advan…
View article: SGLT2 Inhibitors and Curcumin Co-loaded Liposomal Formulations as Synergistic Delivery Systems for Heart Failure Therapy
SGLT2 Inhibitors and Curcumin Co-loaded Liposomal Formulations as Synergistic Delivery Systems for Heart Failure Therapy Open
Background/Objectives: As novel synergistic strategy for heart failure (HF), this study explores the formulation and characterization of liposomal systems co-loaded with SGLT2 inhibitors (dapagliflozin—DAPA and empagliflozin—EMPA) and curc…
View article: A State-of-the-Art Review on Recent Biomedical Application of Polysaccharide-Based Niosomes as Drug Delivery Systems
A State-of-the-Art Review on Recent Biomedical Application of Polysaccharide-Based Niosomes as Drug Delivery Systems Open
The development of nanocarriers for drug delivery has drawn a lot of attention due to the possibility for tailored delivery to the ill region while preserving the neighboring healthy tissue. In medicine, delivering drugs safely and effecti…
View article: Binary and Ternary Inclusion Complexes of Niflumic Acid: Synthesis, Characterization, and Dissolution Profile
Binary and Ternary Inclusion Complexes of Niflumic Acid: Synthesis, Characterization, and Dissolution Profile Open
Although niflumic acid (NA) is one of the most used non-steroidal anti-inflammatory drugs, it suffers from poor solubility, low bioavailability, and significant adverse effects. To address these limitations, the complexation of NA with cyc…
View article: New Chitosan-Based Co-Delivery Nanosystem for Diabetes Mellitus Therapy
New Chitosan-Based Co-Delivery Nanosystem for Diabetes Mellitus Therapy Open
Type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement of oxidative stress in its onset and progression. Pioglitazone (Pio) is an antidiabetic drug that mainly works by reducing insulin resi…
View article: Simultaneous Determination of Pioglitazone and Curcumin from Chitosan-Based Co-delivery Nanosystem for Diabetes Mellitus Therapy
Simultaneous Determination of Pioglitazone and Curcumin from Chitosan-Based Co-delivery Nanosystem for Diabetes Mellitus Therapy Open
Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement of oxidative stress in its onset and progression. Pioglitazone (Pio) is an antidiabetic drug which primarily works by reducing insulin …
View article: Complexes of Ibuprofen Thiazolidin-4-One Derivatives with β-Cyclodextrin: Characterization and In Vivo Release Profile and Biological Evaluation
Complexes of Ibuprofen Thiazolidin-4-One Derivatives with β-Cyclodextrin: Characterization and In Vivo Release Profile and Biological Evaluation Open
Generally, NSAIDs are weakly soluble in water and contain both hydrophilic and hydrophobic groups. One of the most widely used NSAIDs is ibuprofen, which has a poor solubility and high permeability profile. By creating dynamic, non-covalen…
View article: Modern Approaches in Wounds Management
Modern Approaches in Wounds Management Open
Wound management represents a well-known continuous challenge and concern of the global healthcare systems worldwide. The challenge is on the one hand related to the accurate diagnosis, and on the other hand to establishing an effective tr…
View article: New Smart Bioactive and Biomimetic Chitosan-Based Hydrogels for Wounds Care Management
New Smart Bioactive and Biomimetic Chitosan-Based Hydrogels for Wounds Care Management Open
Wound management represents a continuous challenge for health systems worldwide, considering the growing incidence of wound-related comorbidities, such as diabetes, high blood pressure, obesity, and autoimmune diseases. In this context, hy…
View article: Simultaneous Determination of Glibenclamide and Silymarin Released from Chitosan Microparticles by HPLC-ESI-MS Technique: Method Development and Validation
Simultaneous Determination of Glibenclamide and Silymarin Released from Chitosan Microparticles by HPLC-ESI-MS Technique: Method Development and Validation Open
The study aim was to develop and validate a high-performance liquid chromatography–electrospray ionization mass spectrometry (HPLC-ESI-MS) method to simultaneously determine glibenclamide (Gli) and silymarin (Sil) released from chitosan (C…
View article: A Sustainable Approach to a Cleaner Production of Antimicrobial and Biocompatible Protein Fibers
A Sustainable Approach to a Cleaner Production of Antimicrobial and Biocompatible Protein Fibers Open
This study presents the production, characterization, and application of celandine (Chelidonium majus L.) extracts (aqueous, acidic, alcoholic, and ultrasound) on wool fibers and their characterization. The study aims to obtain an ecologic…
View article: Synthesis of novel series of 3,5-disubstituted imidazo[1,2-<i>d</i>] [1,2,4]thiadiazoles involving S<sub>N</sub>Ar and Suzuki–Miyaura cross-coupling reactions
Synthesis of novel series of 3,5-disubstituted imidazo[1,2-<i>d</i>] [1,2,4]thiadiazoles involving S<sub>N</sub>Ar and Suzuki–Miyaura cross-coupling reactions Open
A convenient design of 3,5-disubstituted imidazo[1,2- d ][1,2,4]thiadiazoles is reported from 2-mercaptoimidazole, which afforded a versatile platform that was then used to access a variety of original heterocycles.
View article: Gastroesophageal reflux disease associatedsymptoms management in patients with chronic conditions
Gastroesophageal reflux disease associatedsymptoms management in patients with chronic conditions Open
Gastroesophageal reflux disease is a worldwide prevalent medical condition. It not only impacts the life quality of patients, but also plays a role in the socio-economic aspect in terms of management of symptoms and therapy. Attentive diag…
View article: Counseling a patient presenting gastrointestinal symptoms in the circumstances of a limited range of available medication – social aspects
Counseling a patient presenting gastrointestinal symptoms in the circumstances of a limited range of available medication – social aspects Open
The health and illness concepts have a major significance for both the patient and the healthcare specialists. Therefore, the role of the pharmacist is an extremely important one and, during the pandemic times, the relationship between the…
View article: The symptomatology of the gastroesophageal reflux disease and the first line therapy
The symptomatology of the gastroesophageal reflux disease and the first line therapy Open
Over time, gastroesophageal reflux has undergone an unexpected and at the same time undesirable evolution towards the most commonly diagnosed upper gastrointestinal disease, called gastroesophageal reflux disease. The symptoms of gastroeso…
View article: The role of the pharmacist in the prevention of gastrointestinal diseases
The role of the pharmacist in the prevention of gastrointestinal diseases Open
Pharmacists are health care professionals and their role is to provide health services, recommendations and support to all type of patients with a diversity of pathologies, including gastrointestinal diseases. In the last years, in countri…
View article: Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-Oxadiazole-2-thiol Scaffold
Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-Oxadiazole-2-thiol Scaffold Open
Starting from indomethacin (IND), one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs), new nitric oxide-releasing indomethacin derivatives with 1,3,4-oxadiazole-2-thiol scaffold (NO-IND-OXDs, 8a–p) have been developed…
View article: Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers
Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers Open
In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch, collag…
View article: New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation
New Hyaluronic Acid/Polyethylene Oxide-Based Electrospun Nanofibers: Design, Characterization and In Vitro Biological Evaluation Open
Natural compounds have been used as wound-healing promoters and are also present in today’s clinical proceedings. In this research, different natural active components such as propolis, Manuka honey, insulin, L-arginine, and Calendula offi…
View article: The Professional and Psycho-Emotional Impact of the COVID-19 Pandemic on Medical Care—A Romanian GPs’ Perspective
The Professional and Psycho-Emotional Impact of the COVID-19 Pandemic on Medical Care—A Romanian GPs’ Perspective Open
The aim of this study was to assess the psycho-emotional impact and the adjustment degree of Romanian general practitioners (GPs) in the coronavirus disease 2019 (COVID-19) pandemic context. With a cross-sectional design, the study include…
View article: Simultaneous Determination of Silymarin and Glibenclamide by HPLC–ESI–MS Technique: Method Development and Validation
Simultaneous Determination of Silymarin and Glibenclamide by HPLC–ESI–MS Technique: Method Development and Validation Open
(1) Background: The aim of the study was to develop and validate a HPLC–ESI–MS method to simultaneously determine silymarin (Sil) and glibenclamide (Gly) in aqueous solutions, from chitosan-based microparticles. [...]
View article: New ibuprofen derivatives with thiazolidin-4-one scaffold with improved pharmaco-toxicological profile
New ibuprofen derivatives with thiazolidin-4-one scaffold with improved pharmaco-toxicological profile Open
Background Aryl-propionic acid derivatives with ibuprofen as representative drug are very important for therapy, being recommended especially for anti-inflammatory and analgesic effects. On other hand 1,3-thiazolidine-4-one scaffold is an …
View article: Biological Evaluation of Azetidine-2-One Derivatives of Ferulic Acid as Promising Anti-Inflammatory Agents
Biological Evaluation of Azetidine-2-One Derivatives of Ferulic Acid as Promising Anti-Inflammatory Agents Open
The purpose of this study was to evaluate the in vivo biological potential of new azetidine-2-one derivatives of ferulic acid (6a–f). First, the in vivo acute toxicity of azetidine-2-one derivatives of ferulic acid on Swiss white mice was …
View article: Chitosan-Based Delivery Systems Loaded with Glibenclamide and Lipoic Acid: Formulation, Characterization, and Kinetic Release Studies
Chitosan-Based Delivery Systems Loaded with Glibenclamide and Lipoic Acid: Formulation, Characterization, and Kinetic Release Studies Open
Glibenclamide and lipoic acid are two drugs frequently recommended for the management of diabetes mellitus, and so, the development of a new formulation containing both substances has a great benefit in terms of efficiency and compliance, …
View article: An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management
An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management Open
Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound …