Léo Cantin
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View article: Adult Neurogenesis in the Subventricular Zone of Patients with Huntington's and Parkinson's Diseases and following Long‐Term Treatment with Deep Brain Stimulation
Adult Neurogenesis in the Subventricular Zone of Patients with Huntington's and Parkinson's Diseases and following Long‐Term Treatment with Deep Brain Stimulation Open
Objective Parkinson's and Huntington's diseases are characterized by progressive neuronal loss. Previous studies using human postmortem tissues have shown the impact of neurodegenerative disorders on adult neurogenesis. The extent to which…
View article: Human brain tissue identification using coherent anti-Stokes Raman scattering spectroscopy and diffuse reflectance spectroscopy for deep brain stimulation surgery
Human brain tissue identification using coherent anti-Stokes Raman scattering spectroscopy and diffuse reflectance spectroscopy for deep brain stimulation surgery Open
It is possible to use optical measurements from the DBS lead during surgery to identify WM and GM and possibly the presence of blood in human brain tissue. The proposed optical tool could inform the surgeon during the lead placement if the…
View article: Human Brain Tissue Identification Using Coherent Anti-Stokes Raman Scattering Spectroscopy and Diffuse Reflectance Spectroscopy for Deep Brain Stimulation Surgery
Human Brain Tissue Identification Using Coherent Anti-Stokes Raman Scattering Spectroscopy and Diffuse Reflectance Spectroscopy for Deep Brain Stimulation Surgery Open
We assess the feasibility of using diffuse reflectance spectroscopy (DRS) and coherent anti-Stokes Raman scattering spectroscopy (CARS) as optical tools for human brain tissue identification during deep brain stimulation (DBS) electrode in…
View article: Post-mortem analysis of Parkinson’s disease brains after long-term deep brain stimulation of the subthalamic nucleus
Post-mortem analysis of Parkinson’s disease brains after long-term deep brain stimulation of the subthalamic nucleus Open
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective surgical treatment for Parkinson’s disease (PD), alleviating motor symptoms and restoring patients’ quality of life. Research into the long-term effects of DBS o…
View article: Classification of Qualitative Fieldnotes Collected During Quantitative Sensory Testing: A Step Towards the Development of a New Mixed Methods Approach in Pain Research
Classification of Qualitative Fieldnotes Collected During Quantitative Sensory Testing: A Step Towards the Development of a New Mixed Methods Approach in Pain Research Open
Our findings have highlighted the value of qualitative sensory evaluation during QST and constitute an important milestone in the development of a mixed methods protocol in phenotyping research.
View article: Rise of Raman spectroscopy in neurosurgery: a review
Rise of Raman spectroscopy in neurosurgery: a review Open
The next generation of Raman-based devices are making their way into operating rooms and their clinical translation requires close collaboration between physicians, engineers, and data scientists.
View article: Proposition of the Artificial Intelligence GACPC© Algorithm for DBS Nuclei Targeting Optimization and Postoperative Programming
Proposition of the Artificial Intelligence GACPC© Algorithm for DBS Nuclei Targeting Optimization and Postoperative Programming Open
Objective: The objective of this study was to develop a mathematical solution to standardize nucleus targeting and DBS programming.
View article: Microglial Implication in Parkinson’s Disease: Loss of Beneficial Physiological Roles or Gain of Inflammatory Functions?
Microglial Implication in Parkinson’s Disease: Loss of Beneficial Physiological Roles or Gain of Inflammatory Functions? Open
Microglia, often described as the brain-resident macrophages, play crucial roles in central nervous system development, maintenance, plasticity, and adaptation to the environment. Both aging and chronic stress promote microglial morphologi…
View article: VP191 Peripheral Nerve Field Stimulation For Chronic Low Back Pain
VP191 Peripheral Nerve Field Stimulation For Chronic Low Back Pain Open
INTRODUCTION: Despite numerous medical, pharmacological and surgical approaches for chronic low back pain (LBP), many patients continue to complain of severe disabling pain. Peripheral nerve field stimulation (PNfS), alone or combined with…