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View article: The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals
The influence of environment on bacterial co-abundance in the gut microbiomes of healthy human individuals Open
View article: Polygenic risk score prediction accuracy convergence
Polygenic risk score prediction accuracy convergence Open
Polygenic risk scores (PRSs) models trained from genome-wide association study (GWAS) results are set to play a pivotal role in biomedical research addressing multifactorial human diseases. The prospect of using these risk scores in clinic…
View article: Multitrait Analysis to Decipher the Intertwined Genetic Architecture of Neuroanatomical Phenotypes and Psychiatric Disorders
Multitrait Analysis to Decipher the Intertwined Genetic Architecture of Neuroanatomical Phenotypes and Psychiatric Disorders Open
View article: MANOCCA: a robust and computationally efficient test of covariance in high-dimension multivariate omics data
MANOCCA: a robust and computationally efficient test of covariance in high-dimension multivariate omics data Open
Multivariate analysis is becoming central in studies investigating high-throughput molecular data, yet, some important features of these data are seldom explored. Here, we present MANOCCA (Multivariate Analysis of Conditional CovAriance), …
View article: Gut microbiome co-abundance networks varies with age, sex, smoking status and body mass index
Gut microbiome co-abundance networks varies with age, sex, smoking status and body mass index Open
The gut microbiome is a complex ecosystem whose members develop local interactions to form coherent functional communities. Variability in these communities, typically investigated through taxa co-abundance, might provide critical insights…
View article: Multi-trait GWAS for diverse ancestries: mapping the knowledge gap
Multi-trait GWAS for diverse ancestries: mapping the knowledge gap Open
View article: Linking the genetic structure of neuroanatomical phenotypes with psychiatric disorders
Linking the genetic structure of neuroanatomical phenotypes with psychiatric disorders Open
There is increasing evidence of shared genetic factors between psychiatric disorders and brain magnetic resonance imaging (MRI) phenotypes. However, deciphering the joint genetic architecture of these outcomes has proven challenging, and n…
View article: A multivariate outcome test of covariance
A multivariate outcome test of covariance Open
Multivariate analysis is becoming central in studies investigating high-throughput molecular data, yet, some important features of these data are seldom explored. Here, we present MANOCCA (Multivariate Analysis of Conditional CovAriance), …
View article: Polygenic risk score prediction accuracy convergence
Polygenic risk score prediction accuracy convergence Open
Polygenic risk scores (PRS) trained from genome-wide association study (GWAS) results are set to play a pivotal role in biomedical research addressing multifactorial human diseases. The prospect of using these risk scores in clinical care …
View article: Multi-trait GWAS for diverse ancestries: Mapping the knowledge gap
Multi-trait GWAS for diverse ancestries: Mapping the knowledge gap Open
Background Approximately 95% of samples analyzed in univariate genome-wide association studies (GWAS) are of European ancestry. This bias toward European ancestry populations in association screening also exists for other analyses and meth…
View article: <i>ChoruMM</i>: a versatile multi-components mixed model for bacterial-GWAS
<i>ChoruMM</i>: a versatile multi-components mixed model for bacterial-GWAS Open
Genome-wide Association Studies (GWAS) have been central to studying the genetics of complex human outcomes, and there is now tremendous interest in implementing GWAS-like approaches to study pathogenic bacteria. A variety of methods have …