Martin‐Leo Hansmann
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View article: Migration Dynamics of Human <scp>NK</scp> Cell Preparations in Microchannels and Their Invasion Into Patient‐Derived Tissue
Migration Dynamics of Human <span>NK</span> Cell Preparations in Microchannels and Their Invasion Into Patient‐Derived Tissue Open
Natural killer (NK) cells are characterised by their ability to attack cancer cells without prior antigen stimulation. Additionally, clinical trials revealed great potential of NK cells expressing chimeric antigen receptors (CARs). Success…
View article: Age‐ and gender‐specific molecular characteristics of diffuse large B‐cell lymphoma: Results from clinical trials of the DSHNHL/GLA
Age‐ and gender‐specific molecular characteristics of diffuse large B‐cell lymphoma: Results from clinical trials of the DSHNHL/GLA Open
Diffuse large B‐cell lymphoma (DLBCL) is the most common non‐Hodgkin lymphoma. Despite a high cure rate, too many patients show refractory (ref) or relapsed (rel) disease. This study examines the frequency of recurring gene mutations and t…
View article: Lymphomas in 3D and 4D spaces
Lymphomas in 3D and 4D spaces Open
The cellular compartments in the lymph node form dynamic networks, enabling coordinated innate and adaptive immunological responses. This compartmentalization of the lymph node into subcompartments, such as the T and B zones, has been prov…
View article: <scp>EZB</scp> ‐type diffuse large B‐cell lymphoma cell lines have superior migration capabilities compared to <scp>MCD</scp> ‐type
<span>EZB</span> ‐type diffuse large B‐cell lymphoma cell lines have superior migration capabilities compared to <span>MCD</span> ‐type Open
Summary Diffuse large B‐cell lymphoma (DLBCL) represents the most prevalent aggressive B‐cell lymphoma. The group is heterogeneous and the outcome is variable. A variety of approaches have been employed with the objective of improving the …
View article: Checkpoint inhibition enhances cell contacts between CD4<sup>+</sup> T cells and Hodgkin-Reed-Sternberg cells of classic Hodgkin lymphoma
Checkpoint inhibition enhances cell contacts between CD4<sup>+</sup> T cells and Hodgkin-Reed-Sternberg cells of classic Hodgkin lymphoma Open
Although checkpoint molecules like CTLA-4 and PD1 have been described several years ago, checkpoint inhibitors such as nivolumab (an anti-PD-1 antibody) have only recently been used to treat classic Hodgkin lymphoma (cHL). Several studies …
View article: Computational systems biology of cellular processes in the human lymph node
Computational systems biology of cellular processes in the human lymph node Open
The human immune system is determined by the functionality of the human lymph node. With the use of high-throughput techniques in clinical diagnostics, a large number of data is currently collected. The new data on the spatiotemporal organ…
View article: Transcriptional reprogramming by mutated IRF4 in lymphoma
Transcriptional reprogramming by mutated IRF4 in lymphoma Open
Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements (CE) and the interactio…
View article: Working conditions and self-efficacy among users of psychotherapeutic consultation at work
Working conditions and self-efficacy among users of psychotherapeutic consultation at work Open
Introduction Psychotherapeutic consultation at work (PT-A) aims to prevent sickness absence and to facilitate return to work by offering early intervention and treatment for employees with (subclinical) symptoms of mental disorders. PT-A s…
View article: Clonal composition and differentiation stage of human CD30+ B cells in reactive lymph nodes
Clonal composition and differentiation stage of human CD30+ B cells in reactive lymph nodes Open
Introduction Normal CD30 + B cells represent a distinct B-cell differentiation stage with features of strong activation. We lack an in depth understanding of these cells, because they are not present in peripheral blood and are typically v…
View article: Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms
Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms Open
Knowledge on the pathogenesis of FL is mainly based on data derived from advanced/systemic stages of FL (sFL) and only small cohorts of localized FL (lFL) have been characterized intensively so far. Comprehensive analysis with profiling of…
View article: The RHOA Mutation G17V Does Not Lead to Increased Migration of Human Malignant T Cells but Is Associated with Matrix Remodelling
The RHOA Mutation G17V Does Not Lead to Increased Migration of Human Malignant T Cells but Is Associated with Matrix Remodelling Open
Nodal T-follicular helper cell lymphoma, angioimmunoblastic-type (AITL), is characterized by constitutional symptoms, advanced-stage disease, and generalized lymphadenopathy. A genetic hallmark of this lymphoma is the frequent occurrence o…
View article: Deregulated hsa‐miR‐23a‐3p and hsa‐mir‐148a‐3p influence key processes in classic Hodgkin lymphoma (cHL) pathogenesis
Deregulated hsa‐miR‐23a‐3p and hsa‐mir‐148a‐3p influence key processes in classic Hodgkin lymphoma (cHL) pathogenesis Open
Introduction: We previously performed global miRNA expression profiling of cHL vs. non-Hodgkin lymphoma (NHL) cell lines and sorted germinal centre B-cells (GCB). In the group of 79 deregulated miRNAs (p < 0.05) we became particularly inte…
View article: B-cell receptor reactivity against <i>Rothia mucilaginosa</i> in nodular lymphocyte-predominant Hodgkin lymphoma
B-cell receptor reactivity against <i>Rothia mucilaginosa</i> in nodular lymphocyte-predominant Hodgkin lymphoma Open
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a Hodgkin lymphoma expressing functional B-cell receptors (BCR). Recently, we described a dual stimulation model of IgD+ lymphocyte-predominant cells by Moraxella catarrhalis antig…
View article: Supplementary Data from Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma
Supplementary Data from Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma Open
Supplemental Figure 1 - Representative examples of the histochemistry assay to measure CD73 activity as summarized in Fig. 4D). A 4x objective lens was used to evaluate intensity of dark precipitate correlating with CD73 specific 5′-nucl…
View article: Supplementary files from Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas
Supplementary files from Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas Open
Supplementary figures 1-5, supplementary tables 1-9
View article: Data from Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma
Data from Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma Open
The cellular microenvironment in classical Hodgkin lymphoma (cHL) is dominated by a mixed infiltrate of inflammatory cells with typically only about 1% Hodgkin and Reed/Sternberg (HRS) tumor cells. T cells are usually the largest populatio…
View article: Data from Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas
Data from Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas Open
Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumors with variable clinical, morphologic, and phenotypic characteristics. Transcriptome analysis was performed on multiple FDC sarcomas and compared with other mesenchymal tum…
View article: Data from Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas
Data from Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas Open
Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumors with variable clinical, morphologic, and phenotypic characteristics. Transcriptome analysis was performed on multiple FDC sarcomas and compared with other mesenchymal tum…
View article: Supplementary files from Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas
Supplementary files from Distinctive Histogenesis and Immunological Microenvironment Based on Transcriptional Profiles of Follicular Dendritic Cell Sarcomas Open
Supplementary figures 1-5, supplementary tables 1-9
View article: Data from Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma
Data from Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma Open
The cellular microenvironment in classical Hodgkin lymphoma (cHL) is dominated by a mixed infiltrate of inflammatory cells with typically only about 1% Hodgkin and Reed/Sternberg (HRS) tumor cells. T cells are usually the largest populatio…
View article: Supplementary Data from Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma
Supplementary Data from Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma Open
Supplemental Figure 1 - Representative examples of the histochemistry assay to measure CD73 activity as summarized in Fig. 4D). A 4x objective lens was used to evaluate intensity of dark precipitate correlating with CD73 specific 5′-nucl…
View article: Identification of two unannotated miRNAs in classic Hodgkin lymphoma cell lines
Identification of two unannotated miRNAs in classic Hodgkin lymphoma cell lines Open
MicroRNAs (miRNAs) are small non coding RNAs responsible for posttranscriptional regulation of gene expression. Even though almost 2000 precursors have been described so far, additional miRNAs are still being discovered in normal as well a…
View article: Holistic View on the Structure of Immune Response: Petri Net Model
Holistic View on the Structure of Immune Response: Petri Net Model Open
The simulation of immune response is a challenging task because quantitative data are scarce. Quantitative theoretical models either focus on specific cell–cell interactions or have to make assumptions about parameters. The broad variation…
View article: Imaging bridges pathology and radiology
Imaging bridges pathology and radiology Open
In recent years, medical disciplines have moved closer together and rigid borders have been increasingly dissolved. The synergetic advantage of combining multiple disciplines is particularly important for radiology, nuclear medicine, and p…
View article: A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma
A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma Open
SUMMARY PARAGRAPH Disease-causing mutations in genes encoding transcription factors (TFs) are a recurrent finding in hematopoietic malignancies and might involve key regulators of lineage adherence and cellular differentiation 1–3 . Such m…
View article: P043: Molecular pathogenesis of Hodgkin lymphoma
P043: Molecular pathogenesis of Hodgkin lymphoma Open
Classical Hodgkin lymphoma (cHL) is one of the most frequent lymphomas in the Western world. Its malignant Hodgkin and Reed/Sternberg (HRS) cells are derived from pre-apoptotic germinal center B cells and only account for ca. 1% of the tum…