Lawrence H. Cheung
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View article: Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid
Oleic acid restores the impaired antitumor immunity of γδ-T cells induced by palmitic acid Open
View article: GrB-Fc-KS49, an anti-EMP2 granzyme B fusion protein therapeutic alters immune cell infiltration and suppresses breast cancer growth
GrB-Fc-KS49, an anti-EMP2 granzyme B fusion protein therapeutic alters immune cell infiltration and suppresses breast cancer growth Open
Background Granzyme B (GrB) is a key effector molecule, delivered by cytotoxic T lymphocytes and natural killer cells during immune surveillance to induce cell death. Fusion proteins and immunoconjugates represent an innovative therapeutic…
View article: Enabling "Fuel" Switching through On-Demand Wind Control
Enabling "Fuel" Switching through On-Demand Wind Control Open
This work demonstrates that classical shear-flow stability theory can be successfully applied to modify wind turbine wakes and also explains the success of several emerging, empirically-arrived control methods (i.e., dynamic induction and …
View article: An international benchmark for wind plant wakes from the American WAKE ExperimeNt (AWAKEN)
An international benchmark for wind plant wakes from the American WAKE ExperimeNt (AWAKEN) Open
This article introduces the first benchmark study within the International Energy Agency Wind Task 57 framework, focusing on wind plant wakes. Leveraging data from the American WAKE ExperimeNt (AWAKEN), the benchmark aims to assess the acc…
View article: Offshore Wind Energy Validation Experiment Hierarchy
Offshore Wind Energy Validation Experiment Hierarchy Open
This paper provides a summary of planning work for experiments that will be necessary to address the long-term model validation needs required to meet offshore wind energy deployment goals. Conceptual experiments are identified and laid ou…
View article: Estimating Uncertainties from Dual-Doppler Radar Measurements of Onshore Wind Plants Using LES
Estimating Uncertainties from Dual-Doppler Radar Measurements of Onshore Wind Plants Using LES Open
Towards the ongoing work of improving the capability of flow modeling within and around wind plants, an onshore model validation benchmark campaign is underway based on a field experiment involving multiple wind plants in Oklahoma, U.S.A. …
View article: SEABIRD: System for Environmental Assessment of Bird/Bat Interactions with Real-time Detection: Bird Strike Modeling
SEABIRD: System for Environmental Assessment of Bird/Bat Interactions with Real-time Detection: Bird Strike Modeling Open
View article: Investigations of Farm-to-Farm Interactions and Blockage Effects from AWAKEN Using Large-Scale Numerical Simulations
Investigations of Farm-to-Farm Interactions and Blockage Effects from AWAKEN Using Large-Scale Numerical Simulations Open
View article: Investigations of Farm-to-Farm Interactions and Blockage Effects from AWAKEN Using Large-Scale Numerical Simulations
Investigations of Farm-to-Farm Interactions and Blockage Effects from AWAKEN Using Large-Scale Numerical Simulations Open
A large-scale numerical computation of five wind farms was performed as a part of the American WAKE experimeNt (AWAKEN). This high-fidelity computation used the ExaWind/AMR-Wind LES solver to simulate a 100 km × 100 km domain containing 54…
View article: Preliminary Analysis of Farmwide Lidar and Radar Results in the AWAKEN Experiment
Preliminary Analysis of Farmwide Lidar and Radar Results in the AWAKEN Experiment Open
View article: Wake interactions behind individual-tower multi-rotor wind turbine configurations
Wake interactions behind individual-tower multi-rotor wind turbine configurations Open
Multiple rotors on single structures have long been proposed to increase wind turbine energy capture with no increase in rotor size, but at the cost of additional mechanical complexity in the yaw and tower designs. Standard turbines on the…
View article: A Fluid-Dynamic Perspective on Active Wake Mixing
A Fluid-Dynamic Perspective on Active Wake Mixing Open
View article: Supplementary Tables 1-4 from Development of Human Serine Protease-Based Therapeutics Targeting Fn14 and Identification of Fn14 as a New Target Overexpressed in TNBC
Supplementary Tables 1-4 from Development of Human Serine Protease-Based Therapeutics Targeting Fn14 and Identification of Fn14 as a New Target Overexpressed in TNBC Open
Supplementary Tables 1-4. Supplementary Table 1: In vitro cytotoxicity of GrB-TWEAK Supplementary Table 2: TNBC cell lines are highly sensitive to GrB-Fc-IT4 cytotoxicity Supplementary Table 3: GrB-TWEAK and GrB-Fc-IT4 circumvent MDR1-medi…
View article: Supplementary Figure 3 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Figure 3 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 1372KB, Quantification of Her2/neu level shed from Her2/neu positive cells. A.
View article: Supplementary Figures from The Functionalized Human Serine Protease Granzyme B/VEGF<sub>121</sub> Targets Tumor Vasculature and Ablates Tumor Growth
Supplementary Figures from The Functionalized Human Serine Protease Granzyme B/VEGF<sub>121</sub> Targets Tumor Vasculature and Ablates Tumor Growth Open
Supplementary Figures - PDF file 791K, Supplementary Figure 1. Representative image showing selective detection of CD-31+ pixels using MetaMorph 7.7 imaging software. The original image is shown in Figure 6B. Supplementary Figure 2. Origin…
View article: Data from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Data from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
Recombinant immunotoxins, consisting of single-chain variable fragments (scFv) genetically fused to polypeptide toxins, represent potentially effective candidates for cancer therapeutics. We evaluated the affinity of various anti-Her2/neu …
View article: Data from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Data from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
Recombinant immunotoxins, consisting of single-chain variable fragments (scFv) genetically fused to polypeptide toxins, represent potentially effective candidates for cancer therapeutics. We evaluated the affinity of various anti-Her2/neu …
View article: Supplementary Figure 1 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Figure 1 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 4112KB, Competitive internalization assay of 20nM immunotoxins with different concentration of the Her2/neu ECD on BT474 M1 cells.
View article: Supplementary Figure 5 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Figure 5 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 1877KB, Statistical comparisons of Tissue-to-Muscle Ratio (tumor or liver to muscle ratio) of IRDye800-MH3-B1/rGel and IRDye800-B1D3/rGel after 24h (A) and 72h (B) injection to BT474 M1 xenograft tumors.
View article: Supplementary Figure 2 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Figure 2 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 1631KB, Competitive cytotoxicity of the scFv/rGel in the presence of free Her2/neu ECD.
View article: Supplementary Tables 1-4 from Development of Human Serine Protease-Based Therapeutics Targeting Fn14 and Identification of Fn14 as a New Target Overexpressed in TNBC
Supplementary Tables 1-4 from Development of Human Serine Protease-Based Therapeutics Targeting Fn14 and Identification of Fn14 as a New Target Overexpressed in TNBC Open
Supplementary Tables 1-4. Supplementary Table 1: In vitro cytotoxicity of GrB-TWEAK Supplementary Table 2: TNBC cell lines are highly sensitive to GrB-Fc-IT4 cytotoxicity Supplementary Table 3: GrB-TWEAK and GrB-Fc-IT4 circumvent MDR1-medi…
View article: Supplementary Methods from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Methods from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 155KB
View article: Supplementary Figure 5 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Figure 5 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 1877KB, Statistical comparisons of Tissue-to-Muscle Ratio (tumor or liver to muscle ratio) of IRDye800-MH3-B1/rGel and IRDye800-B1D3/rGel after 24h (A) and 72h (B) injection to BT474 M1 xenograft tumors.
View article: Supplementary Figure 2 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Figure 2 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 1631KB, Competitive cytotoxicity of the scFv/rGel in the presence of free Her2/neu ECD.
View article: Supplementary Figure 6 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Figure 6 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 1215KB, Enzymatic activities of AST and LDH in the serum of mice with or without tumors, treated with rGel, MH3-B1/rGel or B1D3/rGel.
View article: Supplementary Figure 4 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Figure 4 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 2744KB, Ex vivo optical imaging of tumor and other organs after 24 and 72h postinjection of IRDye800-MH3-B1/rGel or IRDye800-B1D3/rGel using the Xenogen IVIS imaging system.
View article: Supplementary Figures from The Functionalized Human Serine Protease Granzyme B/VEGF<sub>121</sub> Targets Tumor Vasculature and Ablates Tumor Growth
Supplementary Figures from The Functionalized Human Serine Protease Granzyme B/VEGF<sub>121</sub> Targets Tumor Vasculature and Ablates Tumor Growth Open
Supplementary Figures - PDF file 791K, Supplementary Figure 1. Representative image showing selective detection of CD-31+ pixels using MetaMorph 7.7 imaging software. The original image is shown in Figure 6B. Supplementary Figure 2. Origin…
View article: Supplementary Figure 3 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Figure 3 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 1372KB, Quantification of Her2/neu level shed from Her2/neu positive cells. A.
View article: Supplementary Figure 1 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Figure 1 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 4112KB, Competitive internalization assay of 20nM immunotoxins with different concentration of the Her2/neu ECD on BT474 M1 cells.
View article: Supplementary Figure 4 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity
Supplementary Figure 4 from Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity Open
PDF file - 2744KB, Ex vivo optical imaging of tumor and other organs after 24 and 72h postinjection of IRDye800-MH3-B1/rGel or IRDye800-B1D3/rGel using the Xenogen IVIS imaging system.