Leon Aarts
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View article: The prevalence, risks, and detection of driving under the influence of nitrous oxide
The prevalence, risks, and detection of driving under the influence of nitrous oxide Open
Nitrous oxide (N 2 O), colloquially known as laughing gas, is a common recreational drug of abuse. The gas is inhaled in its undiluted form from a party balloon. Its intoxicating effects are described as dissociative and euphoric, accompan…
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View article: Stereoselective ketamine effect on cardiac output: a population pharmacokinetic/pharmacodynamic modelling study in healthy volunteers
Stereoselective ketamine effect on cardiac output: a population pharmacokinetic/pharmacodynamic modelling study in healthy volunteers Open
View article: Retinal oximetry with a prototype handheld oximeter during hyperoxia
Retinal oximetry with a prototype handheld oximeter during hyperoxia Open
Purpose Retinal oximetry measures oxygen saturation in retinal vessels. With the introduction of a mobile handheld prototype oximeter, this technique will become available for a broader patient population including bedridden patients and n…
View article: Biventricular function in exercise during autonomic (thoracic epidural) block
Biventricular function in exercise during autonomic (thoracic epidural) block Open
View article: Nociception level monitoring for personalized analgesic treatment. Response to Br J Anaesth 2020; 125: 1070-8
Nociception level monitoring for personalized analgesic treatment. Response to Br J Anaesth 2020; 125: 1070-8 Open
Editor—We thank Coeckelenbergh and colleagues1Coeckelenbergh S. Vereecke H.E.M. Richebé P. Nociception Level-guided fentanyl titration: potential impact of multimodal anaesthesia and false positives. Comment on Br J Anaesth 2020.Br J Anaes…
View article: Deep neuromuscular block does not improve surgical conditions in patients receiving sevoflurane anaesthesia for laparoscopic renal surgery
Deep neuromuscular block does not improve surgical conditions in patients receiving sevoflurane anaesthesia for laparoscopic renal surgery Open
View article: Reduced postoperative pain using Nociception Level-guided fentanyl dosing during sevoflurane anaesthesia: a randomised controlled trial
Reduced postoperative pain using Nociception Level-guided fentanyl dosing during sevoflurane anaesthesia: a randomised controlled trial Open
www.trialregister.nl under identifier NL7845.
View article: Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis
Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis Open
View article: Opioid utility function: methods and implications
Opioid utility function: methods and implications Open
Opioids are complex drugs that produce profit (most importantly analgesia) as well as a myriad of adverse effects including gastrointestinal motility disturbances, abuse and addiction, sedation and potentially lethal respiratory depression…
View article: Reversal of Partial Neuromuscular Block and the Ventilatory Response to Hypoxia
Reversal of Partial Neuromuscular Block and the Ventilatory Response to Hypoxia Open
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background The ventilatory response to hypoxia is a life-saving chemoreflex originating at the carotid bodies that is impaired by nondepolari…
View article: Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia
Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia Open
Editor’s Perspective What We Already Know about This Topic The nociception level index (Medasense Biometrics Ltd., Ramat Gan, Israel), is a reliable measure of moderate to intense noxious stimulation during anesthesia and surgery What This…
View article: Effects of Thoracic Epidural Anesthesia on Neuronal Cardiac Regulation and Cardiac Function
Effects of Thoracic Epidural Anesthesia on Neuronal Cardiac Regulation and Cardiac Function Open
Cardiac sympathetic blockade with high-thoracic epidural anesthesia is considered beneficial in patients undergoing major surgery because it offers protection in ischemic heart disease. Major outcome studies have failed to confirm such a b…
View article: The use of surgical rating scales for the evaluation of surgical working conditions during laparoscopic surgery: a scoping review
The use of surgical rating scales for the evaluation of surgical working conditions during laparoscopic surgery: a scoping review Open
Handheld Retinal Oximetry in Healthy Young Adults Open
View article: Vasoplegia After Surgical Left Ventricular Restoration: 2-Year Follow-Up
Vasoplegia After Surgical Left Ventricular Restoration: 2-Year Follow-Up Open
View article: Impact of high- versus low-dose neuromuscular blocking agent administration on unplanned 30-day readmission rates in retroperitoneal laparoscopic surgery
Impact of high- versus low-dose neuromuscular blocking agent administration on unplanned 30-day readmission rates in retroperitoneal laparoscopic surgery Open
Recent data shows that a neuromuscular block (NMB) induced by administration of high doses of rocuronium improves surgical conditions in certain procedures. However, there are limited data on the effect such practices on postoperative outc…
View article: Esketamine counters opioid-induced respiratory depression
Esketamine counters opioid-induced respiratory depression Open
View article: Averting Opioid-induced Respiratory Depression without Affecting Analgesia
Averting Opioid-induced Respiratory Depression without Affecting Analgesia Open
The ventilatory control system is highly vulnerable to exogenous administered opioid analgesics. Particularly respiratory depression is a potentially lethal complication that may occur when opioids are overdosed or consumed in combination …
View article: Ketamine for pain
Ketamine for pain Open
The efficacy of theN-methyl-D-aspartate receptor antagonist ketamine as an analgesic agent is still under debate, especially for indications such as chronic pain. To understand the efficacy of ketamine for relief of pain, we performed a li…
View article: Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain
Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain Open
Cibinetide significantly increased small nerve fiber abundance in the cornea and skin, consistent with a disease modifying effect. The relationships between CNFA and other clinical measures of disease support its use as a surrogate endpoin…
View article: Handheld and mobile oximeter in a healthy adult population
Handheld and mobile oximeter in a healthy adult population Open
View article: Thoracic Epidural Anesthesia Reduces Right Ventricular Systolic Function With Maintained Ventricular-Pulmonary Coupling
Thoracic Epidural Anesthesia Reduces Right Ventricular Systolic Function With Maintained Ventricular-Pulmonary Coupling Open
Background: Blockade of cardiac sympathetic fibers by thoracic epidural anesthesia may affect right ventricular function and interfere with the coupling between right ventricular function and right ventricular afterload. Our main objective…
View article: Improved postoperative oxygenation after antagonism of moderate neuromuscular block with sugammadex versus neostigmine after extubation in ‘blinded’ conditions
Improved postoperative oxygenation after antagonism of moderate neuromuscular block with sugammadex versus neostigmine after extubation in ‘blinded’ conditions Open
View article: Erythropoietin does not have effects on the ventilatory and pulmonary vascular response to acute hypoxia in men and women
Erythropoietin does not have effects on the ventilatory and pulmonary vascular response to acute hypoxia in men and women Open
New Findings What is the central question of this study? Does a clinically relevant intravenous dose of erythropoeitin affect the hypoxic ventilatory response and/or hypoxic pulmonary vasoconstriction in healthy humans? What is the main fi…
View article: Non‐invasive continuous arterial pressure and pulse pressure variation measured with Nexfin <sup>®</sup> in patients following major upper abdominal surgery: a comparative study
Non‐invasive continuous arterial pressure and pulse pressure variation measured with Nexfin <sup>®</sup> in patients following major upper abdominal surgery: a comparative study Open
Summary We compared the accuracy and precision of the non‐invasive Nexfin ® device for determining systolic, diastolic, mean arterial pressure and pulse pressure variation, with arterial blood pressure values measured from a radial artery …
View article: The effect of propofol on haemodynamics: cardiac output, venous return, mean systemic filling pressure, and vascular resistances
The effect of propofol on haemodynamics: cardiac output, venous return, mean systemic filling pressure, and vascular resistances Open
View article: Influence of variations in arterial PCO2 on surgical conditions during laparoscopic retroperitoneal surgery
Influence of variations in arterial PCO2 on surgical conditions during laparoscopic retroperitoneal surgery Open
View article: A Randomized Controlled Trial on the Effect of Tapentadol and Morphine on Conditioned Pain Modulation in Healthy Volunteers
A Randomized Controlled Trial on the Effect of Tapentadol and Morphine on Conditioned Pain Modulation in Healthy Volunteers Open
Netherlands Trial Register NTR2716.