Leon C. W. Lin
YOU?
Author Swipe
View article: Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification
Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification Open
View article: Trends and forecast of drug-resistant tuberculosis: a global perspective from the GBD study 2021
Trends and forecast of drug-resistant tuberculosis: a global perspective from the GBD study 2021 Open
Background Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis . Drug-resistant tuberculosis (DRTB) includes multidrug-resistant tuberculosis without extensive drug resistance (MDRTB) and extensively drug-resist…
View article: Severe traumatic brain injury temporally affects cerebral blood flow, endothelial cell phenotype, and cilia
Severe traumatic brain injury temporally affects cerebral blood flow, endothelial cell phenotype, and cilia Open
Background Previous clinical work suggested that altered cerebral blood flow (CBF) in severe traumatic brain injury (sTBI) correlates with poor executive function and clinical outcome. However, the molecular consequences of altered CBF on …
View article: Lymph Node Follicle‐Targeting STING Agonist Nanoshells Enable Single‐Shot M2e Vaccination for Broad and Durable Influenza Protection
Lymph Node Follicle‐Targeting STING Agonist Nanoshells Enable Single‐Shot M2e Vaccination for Broad and Durable Influenza Protection Open
The highly conserved matrix protein 2 ectodomain (M2e) of influenza viruses presents a compelling vaccine antigen candidate for stemming the pandemic threat of the mutation‐prone pathogen, yet the low immunogenicity of the diminutive M2e p…
View article: Optimizing variant-specific therapeutic SARS-CoV-2 decoys using deep-learning-guided molecular dynamics simulations
Optimizing variant-specific therapeutic SARS-CoV-2 decoys using deep-learning-guided molecular dynamics simulations Open
View article: Optimizing variant-specific therapeutic SARS-CoV-2 decoys using deep-learning-guided molecular dynamic simulations.
Optimizing variant-specific therapeutic SARS-CoV-2 decoys using deep-learning-guided molecular dynamic simulations. Open
Treatment of COVID-19 with a soluble version of ACE2 that binds to SARS-CoV-2 virions before they enter host cells is a promising approach, but it needs to be optimized and adapted to emerging viral variants. The computational workflow pre…
View article: Integrated Design of a Membrane‐Lytic Peptide‐Based Intravenous Nanotherapeutic Suppresses Triple‐Negative Breast Cancer
Integrated Design of a Membrane‐Lytic Peptide‐Based Intravenous Nanotherapeutic Suppresses Triple‐Negative Breast Cancer Open
Membrane‐lytic peptides offer broad synthetic flexibilities and design potential to the arsenal of anticancer therapeutics, which can be limited by cytotoxicity to noncancerous cells and induction of drug resistance via stress‐induced muta…
View article: Boosting BCG with recombinant influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against Mycobacterium tuberculosis infection
Boosting BCG with recombinant influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against Mycobacterium tuberculosis infection Open
The current Mycobacterium bovis BCG vaccine provides inconsistent protection against pulmonary infection with Mycobacterium tuberculosis . Immunity induced by subcutaneous immunization with BCG wanes and does not promote early recruitment …
View article: Direct Priming of CD8<sup>+</sup>T Cells Persists in the Face of Cowpox Virus Inhibitors of Antigen Presentation
Direct Priming of CD8<sup>+</sup>T Cells Persists in the Face of Cowpox Virus Inhibitors of Antigen Presentation Open
CD8 + T cells are key to antiviral immunity, so it is important to understand how they are activated. Many viruses have proteins that protect infected cells from T cell attack by interfering with the process that allows virus infection to …
View article: Boosting BCG with recombinant influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against Mycobacterium tuberculosis infection
Boosting BCG with recombinant influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against Mycobacterium tuberculosis infection Open
\n\t\t\t\t\tThe current Mycobacterium bovis BCG vaccine provides inconsistent protection against pulmonary infection with Mycobacterium tuberculosis. Immunity induced by subcutaneous immunization with BCG wanes and does not promote early r…
View article: Boosting BCG with recombinant Influenza A virus-based TB vaccines.
Boosting BCG with recombinant Influenza A virus-based TB vaccines. Open
Data contains minimal dataset for figures and supporting information files in the paper titled " Boosting BCG with recombinant Influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against My…
View article: Boosting BCG with recombinant Influenza A virus-based TB vaccines.
Boosting BCG with recombinant Influenza A virus-based TB vaccines. Open
Data contains minimal dataset for figures and supporting information files in the paper titled " Boosting BCG with recombinant Influenza A virus tuberculosis vaccines increases pulmonary T cell responses but not protection against My…
View article: Simultaneous determination of magnesium ascorbyl phosphate, ascorbyl glucoside, kojic acid, arbutin and hydroquinone in skin whitening cosmetics by HPLC
Simultaneous determination of magnesium ascorbyl phosphate, ascorbyl glucoside, kojic acid, arbutin and hydroquinone in skin whitening cosmetics by HPLC Open
A high performance liquid chromatographic method was developed for simultaneous determination of 5 whitening ingredients: magnesium ascorbyl phosphate, ascorbyl glucoside, kojic acid, arbutin and hydroquinone decomposed from arbutin in cos…
View article: Determination of α-hydroxyacids in cosmetics
Determination of α-hydroxyacids in cosmetics Open
A high performance liquid chromatographic method was developed for the simultaneous determination of four α-hydroxyacids (AHAs, Glycolic acid, dl-Malic acid, Lactic acid and Citric acid) in cosmetics. Samples were analyzed using a reverse-…
View article: Modified Vaccinia Virus Ankara Can Induce Optimal CD8<sup>+</sup>T Cell Responses to Directly Primed Antigens Depending on Vaccine Design
Modified Vaccinia Virus Ankara Can Induce Optimal CD8<sup>+</sup>T Cell Responses to Directly Primed Antigens Depending on Vaccine Design Open
Recombinant vaccines based on vaccinia virus and particularly attenuated strains such as MVA are in human clinical trials, but due to the complexity of these large vectors much remains to be understood about the design parameters that alte…
View article: Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus
Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus Open
The continued threat of emerging, highly lethal infectious pathogens such as Middle East respiratory syndrome coronavirus (MERS‐CoV) calls for the development of novel vaccine technology that offers safe and effective prophylactic measures…
View article: CXCR6-Deficiency Improves the Control of Pulmonary Mycobacterium tuberculosis and Influenza Infection Independent of T-Lymphocyte Recruitment to the Lungs
CXCR6-Deficiency Improves the Control of Pulmonary Mycobacterium tuberculosis and Influenza Infection Independent of T-Lymphocyte Recruitment to the Lungs Open
T-lymphocytes are critical for protection against respiratory infections, such as Mycobacterium tuberculosis and influenza virus, with chemokine receptors playing an important role in directing these cells to the lungs. CXCR6 is exp…
View article: Pulmonary immunization with a recombinant influenza A virus vaccine induces lung-resident CD4+ memory T cells that are associated with protection against tuberculosis
Pulmonary immunization with a recombinant influenza A virus vaccine induces lung-resident CD4+ memory T cells that are associated with protection against tuberculosis Open
View article: PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection
PLGA particulate subunit tuberculosis vaccines promote humoral and Th17 responses but do not enhance control of Mycobacterium tuberculosis infection Open
Tuberculosis places a staggering burden on human health globally. The new World Health Organisation End-TB Strategy has highlighted the urgent need for more effective TB vaccines to improve control of the disease. Protein-based subunit vac…
View article: Genome Sequences of Gordonia terrae Phages Benczkowski14 and Katyusha
Genome Sequences of Gordonia terrae Phages Benczkowski14 and Katyusha Open
Bacteriophages Katyusha and Benczkowski14 are newly isolated phages that infect Gordonia terrae 3612. Both have siphoviral morphologies with isometric heads and long tails (500 nm). The genomes are 75,380 bp long and closely related, and t…