Leon Chen
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View article: A Case study of polypharmacy-induced serotonin syndrome in a cancer patient
A Case study of polypharmacy-induced serotonin syndrome in a cancer patient Open
Polypharmacy in cancer care can be complex and detrimental, particularly among younger patients, who can be easily overlooked. This report showcases a 54-year-old woman with cancer, treated for dapsone-induced methemoglobinemia with methyl…
View article: Best Practices for Point of Care Ultrasound: An Interdisciplinary Expert Consensus
Best Practices for Point of Care Ultrasound: An Interdisciplinary Expert Consensus Open
Despite the growing use of point of care ultrasound (POCUS) in contemporary medical practice and the existence of clinical guidelines addressing its specific applications, there remains a lack of standardization and agreement on optimal pr…
View article: A Case Series of Patients With Complex Airway Disease and Large Thyroid Tumors Anterior to the Trachea Precluding Tracheostomy
A Case Series of Patients With Complex Airway Disease and Large Thyroid Tumors Anterior to the Trachea Precluding Tracheostomy Open
BACKGROUND: This case series explores the management of respiratory failure in patients with large anterior tracheal thyroid tumors where tracheostomy is not an option. To our knowledge, this study is the first to address the challenges as…
View article: Management of Pericardial Effusion in Patients With Solid Tumor
Management of Pericardial Effusion in Patients With Solid Tumor Open
Objective: This study compared outcomes in patients with solid tumor treated for pericardial effusion with surgical drainage versus interventional radiology (IR) percutaneous drainage and compared incidence of paradoxical hemodynamic insta…
View article: Switching Hedgehog inhibitors and other strategies to address resistance when treating advanced basal cell carcinoma
Switching Hedgehog inhibitors and other strategies to address resistance when treating advanced basal cell carcinoma Open
Although basal cell carcinoma (BCC) is often managed successfully with surgery, patients with locally advanced BCC (laBCC) or metastatic BCC (mBCC) who are not candidates for surgery or radiotherapy have limited treatment options. Most BCC…
View article: Painful Retiform Purpura with Cutaneous Necrosis
Painful Retiform Purpura with Cutaneous Necrosis Open
Levamisole-induced vasculitis is characterized by a painful, purpuric rash in a retiform or stellate pattern with or without central necrosis that commonly involves the trunk, extremities, digits, distal nose, cheeks, and ear helices. This…
View article: Necrotizing fasciitis: A comprehensive review.
Necrotizing fasciitis: A comprehensive review. Open
Necrotizing soft-tissue infections (NSTIs) are rare but rapidly progressive, life-threatening bacterial infections with high morbidity and mortality. NSTIs include necrotizing forms of fasciitis, myositis, and cellulitis. This article focu…
View article: CCRN® certification
CCRN® certification Open
AACN Certification Corporation drives patient health and safety through comprehensive credentialing of acute and critical care nurses, advancing practice consistent with standards of excellence. VISIONAll nurses caring for acutely and crit…
View article: Correlation of well-being during dermatology residency with future career plans
Correlation of well-being during dermatology residency with future career plans Open
This study showed that resident well-being can have a significant impact on residents' future career plans, including pursuing academic dermatology, clinical research, and fellowship. Addressing burnout in the field of dermatology offers a…
View article: An Uncommon Cause of Chest Pain
An Uncommon Cause of Chest Pain Open
Chest pain is a common and high-risk chief complaint in the emergency department. There is an array of cardiac and non–cardiac-related conditions that could lead to this symptom. It is important for the clinician to have a broad perspectiv…
View article: Analyzing Motivation Factors for NASCAR Spectators with Self-Determination Theory
Analyzing Motivation Factors for NASCAR Spectators with Self-Determination Theory Open
Research in consumer motivation might ignore auto racing sport that features the number one of fan attendance for single sport event in America. What would be the explicit motives to push individuals themselves or the incentives to pull th…
View article: The RSNA Pediatric Bone Age Machine Learning Challenge
The RSNA Pediatric Bone Age Machine Learning Challenge Open
Purpose The Radiological Society of North America (RSNA) Pediatric Bone Age Machine Learning Challenge was created to show an application of machine learning (ML) and artificial intelligence (AI) in medical imaging, promote collaboration t…
View article: Erythema Ab Igne from Heating Pad Use: A Report of Three Clinical Cases and a Differential Diagnosis
Erythema Ab Igne from Heating Pad Use: A Report of Three Clinical Cases and a Differential Diagnosis
Open
Erythema ab igne is an asymptomatic cutaneous disorder characterized by erythematous reticulated hyperpigmentation resulting from chronic exposure to infrared radiation in the form of heat. We report three cases of erythema ab igne from ch…
View article: A case report of bosutinib-induced interstitial granulomatous drug reaction in a patient with chronic myelogenous leukemia: a case report
A case report of bosutinib-induced interstitial granulomatous drug reaction in a patient with chronic myelogenous leukemia: a case report Open
Bosutinib is a BCR-ABL tyrosine kinase inhibitor approved for the treatment of Philadelphia chromosome–positive chronic myelogenous leukemia. We report a case of bosutinib-induced interstitial granulomatous drug reaction in a 50-year-old C…
View article: Leukocytoclastic vasculitis with late-onset Henoch-Schönlein purpura after trifluridine/tipiracil treatment
Leukocytoclastic vasculitis with late-onset Henoch-Schönlein purpura after trifluridine/tipiracil treatment Open
Trifluridine/tipiracil has been approved for the treatment of refractory metastatic colorectal cancer. Adverse effects of this drug combination include leukopenia, neutropenia, fatigue, diarrhea, and vomiting. We present a case of trifluri…
View article: Chronic granulomatous reaction in patients receiving vaccine immunotherapy for metastatic melanoma
Chronic granulomatous reaction in patients receiving vaccine immunotherapy for metastatic melanoma Open
Various agents such as melanoma-associated antigen 3 (MAGE-3), interleukin-2 (IL-2), gp100, and toll-like receptor agonists have been investigated as therapies for melanoma because of their ability to stimulate an immune response against m…
View article: Treatment of Advanced Basal Cell Carcinoma with Sonidegib: Perspective from the 30-Month Update of the BOLT Trial
Treatment of Advanced Basal Cell Carcinoma with Sonidegib: Perspective from the 30-Month Update of the BOLT Trial Open
Sonidegib, a hedgehog pathway inhibitor, was approved by the US FDA for the treatment of locally advanced basal cell carcinoma which cannot be readily treated with surgery or radiotherapy. The pharmacology and pharmacokinetics of sonidegib…
View article: Hedgehog pathway inhibition in advanced basal cell carcinoma: latest evidence and clinical usefulness
Hedgehog pathway inhibition in advanced basal cell carcinoma: latest evidence and clinical usefulness Open
Treatment of locally advanced basal cell carcinomas (laBCCs) with large, aggressive, destructive, and disfiguring tumors, or metastatic disease is challenging. Dysregulation of the Hedgehog (Hh) signaling pathway has been identified in the…