Explanipedia

Deletion of the TRPV1 channel attenuates afferent renal nerve responses to renal artery occlusion but not elevated renal pelvic pressure Open

Jacob B. Sullivan, Leon J. DeLalio, Sean D. Stocker · 2025

Renal sensory neurons widely express the transient receptor potential vanilloid type 1 (TRPV1). TRPV1 is a non‐selective cation channel responsive to mechanosensitive stimuli, temperature, pH and various chemical factors. The present study…

Pannexin channels in the kidney Open

Michael E. Williams, Brooke L. O’Donnell, Linda Columbus, Leon J. DeLalio, Uta Erdbrügger , et al. · 2025

Renal dysfunction leads to critical health conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD), and is a driver of hypertension. Despite their global prevalence and impact, the pathophysiology for all kidney di…

Endothelial alpha globin is a nitrite reductase Open

T.C. Stevenson Keller, Christophe Lechauve, Alexander Keller, Gilson Brás Broseghini-Filho, Joshua T. Butcher , et al. · 2022

Sympathoexcitatory responses to renal chemosensitive stimuli are exaggerated at nighttime in rats Open

Leon J. DeLalio, Sean D. Stocker · 2022

The current study discovers that the circadian cycle influences sympathetic and hemodynamic responses to activation of renal chemosensitive sensory fibers. Sympathetic responses to intrarenal bradykinin or capsaicin infusion were exaggerat…

Impact of anesthesia and sex on sympathetic efferent and hemodynamic responses to renal chemo- and mechanosensitive stimuli Open

Leon J. DeLalio, Sean D. Stocker · 2021

The findings highlight the impact of anesthesia, and to a lesser extent sex, on sympathetic efferent and hemodynamic responses to chemosensory and mechanosensory renal stimuli. Sympathetic nerve activity (SNA) and arterial blood pressure (…

A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability Open

Daniela Begandt, H. Skye Comstra, Samuel A. Molina, Nenja Krüger, Claire A. Ruddiman , et al. · 2021

A pathway underlying the TNFα-induced decrease in endothelial barrier function is found in veins but not arteries.

Endothelial alpha globin is a nitrite reductase Open

T.C. Stevenson Keller, Alexander Keller, Gilson Brás Broseghini-Filho, Joshua T. Butcher, Henry R. Askew Page , et al. · 2021

Small artery vasodilation in response to hypoxia is essential for matching oxygen supply to tissue oxygen demand. One source of hypoxic dilation via nitric oxide (NO) signaling is nitrite reduction by erythrocytic hemoglobin (α2β2). Howeve…

Impact of anesthesia, sex, and circadian cycle on renal afferent nerve sensitivity Open

Leon J. DeLalio, Sean D. Stocker · 2020

We determined the impact of anesthesia, sex, and circadian cycle on renal afferent nerve (ARNA) sensitivity to chemical and mechanical stimuli. ARNA sensitivity to renal capsaicin infusion was greatest in decerebrate > Inactin > urethane o…

Pannexin 1 channels in renin-expressing cells influence renin secretion and blood pressure homeostasis Open

Leon J. DeLalio, Ester Masati, Suresh K. Mendu, Claire A. Ruddiman, Yang Yang , et al. · 2020

Table of Contents Open

Rhian M. Touyz, Ross D. Feldman, David K. Harrison, Ernesto L. Schiffrin, Jordan Tannenbaum , et al. · 2020

Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium Open

Yang Yang, Leon J. DeLalio, Angela K. Best, Edgar Macal, Jenna Milstein , et al. · 2020

The proinflammatory cytokine IL-1β is a significant risk factor in cardiovascular disease that can be targeted to reduce major cardiovascular events. IL-1β expression and release are tightly controlled by changes in intracellular Ca2+ ([Ca…

Excessive dietary salt promotes aortic stiffness in murine renovascular hypertension Open

Leon J. DeLalio, Scott Hahn, Pedro L. Katayama, Megan M. Wenner, William B. Farquhar , et al. · 2020

High dietary salt exaggerates hypertension in multiple experimental models. Here we demonstrate that a high-salt diet produces a greater increase in arterial blood pressure at 1 wk after induction of 2-kidney, 1-clip (2K1C) hypertension bu…

Sympathetic Nervous System Contributions to Hypertension: Updates and Therapeutic Relevance Open

Leon J. DeLalio, Alan F. Sved, Sean D. Stocker · 2020

Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity Open

Matteo Ottolini, Kwangseok Hong, Eric L Cope, Zdravka Daneva, Leon J. DeLalio , et al. · 2020

Background: Impaired endothelium-dependent vasodilation is a hallmark of obesity-induced hypertension. The recognition that Ca 2+ signaling in endothelial cells promotes vasodilation has led to the hypothesis that endothelial Ca 2+ signali…

Loss of Endothelial FTO Antagonizes Obesity-Induced Metabolic and Vascular Dysfunction Open

Nenja Krüger, Lauren A. Biwer, Miranda E. Good, Claire A. Ruddiman, Abigail G. Wolpe , et al. · 2019

Rationale: Increasing prevalence of obesity and its associated risk with cardiovascular diseases demands a better understanding of the contribution of different cell types within this complex disease for developing new treatment options. P…

Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver Open

Bruce A. Corliss, Leon J. DeLalio, T.C. Stevenson Keller, Alexander Keller, Douglas A. Keller , et al. · 2019

Frigid temperatures of the Southern Ocean are known to be an evolutionary driver in Antarctic fish. For example, many fish have reduced red blood cell (RBC) concentration to minimize vascular resistance. Via the oxygen-carrying prot…

Endothelial pannexin 1 channels control inflammation by regulating intracellular calcium Open

Yang Yang, Leon J. DeLalio, Angela K. Best, Edgar Macal, Jenna Milstein , et al. · 2019

In Brief Interleukine-1 beta (IL-1β) has been identified as a critical factor that contributes to the inflammatory response in cardiovascular disease (e.g., atherosclerosis). Pannexin 1 (Panx1) channel activity in endothelial cells regulat…

Vascular Expression of Hemoglobin Alpha in Antarctic Icefish Supports Iron Limitation as Novel Evolutionary Driver Open

Bruce A. Corliss, Leon J. DeLalio, T.C. Stevenson Keller, Alexander Keller, Douglas A. Keller , et al. · 2019

Frigid temperatures of the Southern Ocean are known to be an evolutionary driver in Antarctic fish. For example, many fish have reduced red blood cell (RBC) concentration to minimize vascular resistance. Via the oxygen-carrying protein hem…

Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane Open

Leon J. DeLalio, Marie Billaud, Claire A. Ruddiman, Scott R. Johnstone, Joshua T. Butcher , et al. · 2019

Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice Open

Nicole M. Novielli‐Kuntz, Meghan Jelen, Kevin Barr, Leon J. DeLalio, Qingping Feng , et al. · 2019

Connexins (Cxs) and pannexins (Panxs) are highly regulated large-pore channel-forming proteins that participate in cellular communication via small molecular exchange with the extracellular microenvironment, or in the case of connexins, di…

Vascular Smooth Muscle Remodeling in Conductive and Resistance Arteries in Hypertension Open

Isola A.M. Brown, Lukas Diederich, Miranda E. Good, Leon J. DeLalio, Sara A. Murphy , et al. · 2018

Cardiovascular disease is a leading cause of death worldwide and accounts for >17.3 million deaths per year, with an estimated increase in incidence to 23.6 million by 2030. 1 Cardiovascular death represents 31% of all global deaths 2 —wit…

Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure Open

Leon J. DeLalio, Alexander Keller, Jiwang Chen, Andrew K. J. Boyce, Mykhaylo Artamonov , et al. · 2018

Objective— Sympathetic nerve innervation of vascular smooth muscle cells (VSMCs) is a major regulator of arteriolar vasoconstriction, vascular resistance, and blood pressure. Importantly, α–adrenergic receptor stimulation, which uniquely c…

TRPV4 (Transient Receptor Potential Vanilloid 4) Channel–Dependent Negative Feedback Mechanism Regulates G <sub>q</sub> Protein–Coupled Receptor–Induced Vasoconstriction Open

Kwangseok Hong, Eric L Cope, Leon J. DeLalio, Corina Marziano, Brant E. Isakson , et al. · 2018

Objective— Several physiological stimuli activate smooth muscle cell (SMC) G q PCRs (G q protein–coupled receptors) to cause vasoconstriction. As a protective mechanism against excessive vasoconstriction, SMC G q PCR stimulation invokes en…

Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone Open

Miranda E. Good, Yu‐Hsin Chiu, Ivan K. H. Poon, Christopher B. Medina, Joshua T. Butcher , et al. · 2017

Rationale: Resistant hypertension is a major health concern with unknown cause. Spironolactone is an effective antihypertensive drug, especially for patients with resistant hypertension, and is considered by the World Health Organization a…

Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway Open

Alexander Keller, Lukas Diederich, Christina Panknin, Leon J. DeLalio, Joshua C. Drake , et al. · 2017

Red blood cell (RBC)-derived adenosine triphosphate (ATP) has been proposed as an integral component in the regulation of oxygen supply to skeletal muscle. In ex vivo settings RBCs have been shown to release ATP in response to a number of …

ZP1609/danegaptide and mitochondrial connexin hemichannels: a harbinger for peptide drug design Open

Leon J. DeLalio, Brant E. Isakson · 2017

Linked Articles This article is a Commentary on Boengler K, Bulic M, Schreckenberg R, Schlüter K‐D, Schulz R (2017). The gap junction modifier ZP1609 decreases cardiomyocyte hypercontracture following ischaemia/reperfusion independent from…

Pannexin channel and connexin hemichannel expression in vascular function and inflammation Open

Daniela Begandt, Miranda E. Good, Alex S. Keller, Leon J. DeLalio, Carol A. Rowley , et al. · 2017

Control of blood flow distribution and tissue homeostasis depend on the tight regulation of and coordination between the microvascular network and circulating blood cells. Channels formed by connexins or pannexins that connect the intra- a…

Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX) Open

T.C. Stevenson Keller, Joshua T. Butcher, Gilson Brás Broseghini-Filho, Corina Marziano, Leon J. DeLalio , et al. · 2016

The ability of hemoglobin to scavenge the potent vasodilator nitric oxide (NO) in the blood has been well established as a mechanism of vascular tone homeostasis. In endothelial cells, the alpha chain of hemoglobin (hereafter, alpha globin…

AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus Open

Shufeng Liu, Leon J. DeLalio, Brant E. Isakson, Tony T. Wang · 2016

Rationale: The mosquito-borne Zika virus (ZIKV) is now recognized as a blood-borne pathogen, raising an important question about how the virus gets into human bloodstream. The imminent threat of the ZIKV epidemic to the global blood supply…

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation Open

Alexander W. Lohman, Igor L. Leskov, Joshua T. Butcher, Scott R. Johnstone, Tara A. Stokes , et al. · 2015

Inflammatory cell recruitment to local sites of tissue injury and/or infection is controlled by a plethora of signalling processes influencing cell-to-cell interactions between the vascular endothelial cells (ECs) in post-capillary venules…

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