Leon M. Ptaszek
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View article: Racial/Ethnic Disparities in Anticoagulation for Atrial Fibrillation by Sex and Within High and Low Stroke Risk Populations
Racial/Ethnic Disparities in Anticoagulation for Atrial Fibrillation by Sex and Within High and Low Stroke Risk Populations Open
Atrial fibrillation (AF) increases the risk of thromboembolic stroke, and oral anticoagulants (OACs) are an effective tool to reduce this risk. Previous studies have demonstrated that female, black, Hispanic, and Asian groups are less like…
View article: Outcomes of Patients With Takotsubo Syndrome Compared With Type 1 and Type 2 Myocardial Infarction
Outcomes of Patients With Takotsubo Syndrome Compared With Type 1 and Type 2 Myocardial Infarction Open
Background Takotsubo syndrome (TS) and myocardial infarction (MI) share similar clinical and laboratory characteristics but have important differences in causes, demographics, management, and outcomes. Methods and Results In this observati…
View article: Coordination of Atrial Fibrillation Management in the Emergency Department and Outpatient Settings
Coordination of Atrial Fibrillation Management in the Emergency Department and Outpatient Settings Open
Historically, a majority of patients presenting to the Emergency Department (ED) with a primary diagnosis of atrial fibrillation (AF) have been admitted to an inpatient unit. Treatment protocols for AF management in the ED have been shown …
View article: Global disparities in arrhythmia care: Mind the gap
Global disparities in arrhythmia care: Mind the gap Open
Delivery of comprehensive arrhythmia care requires the simultaneous presence of many resources. These include complex hospital infrastructure, expensive implantable equipment, and expert personnel. In many low- and middle-income countries …
View article: Safe and effective delivery of high-power, short-duration radiofrequency ablation lesions with a flexible-tip ablation catheter
Safe and effective delivery of high-power, short-duration radiofrequency ablation lesions with a flexible-tip ablation catheter Open
An investigational ablation catheter effectively delivered RFA lesions. Ablation time required to achieve PVI with HPSD with this catheter was >3-fold shorter than with LPLD RFA.
View article: Outcomes of Patients Hospitalized With Cardiovascular Implantable Electronic Device–Related Infective Endocarditis, Prosthetic Valve Endocarditis, and Native Valve Endocarditis: A Nationwide Study, 2003 to 2017
Outcomes of Patients Hospitalized With Cardiovascular Implantable Electronic Device–Related Infective Endocarditis, Prosthetic Valve Endocarditis, and Native Valve Endocarditis: A Nationwide Study, 2003 to 2017 Open
Background Most published reports describing outcomes of patients with cardiovascular implantable electronic device–related infective endocarditis (CIED‐IE) are single‐center studies with small patient sample sizes. The goal of this study …
View article: Author Correction: A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus
Author Correction: A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus Open
In the version of this article initially published, there were errors in the inset graph to Fig. 2a, where the inset had the graph lines and symbols for the 0.3 mg kg -1 and the 0.6 mg kg -1 switched, and the wrong data were shown for the …
View article: A Practical Guide to Ultrasound-guided Venous Access During Implantation of Pacemakers and Defibrillators
A Practical Guide to Ultrasound-guided Venous Access During Implantation of Pacemakers and Defibrillators Open
Ultrasound (US) guidance has been shown to be a safe and effective option for gaining access to the axillary vein during implantation of cardiovascular implantable electronic devices (CIEDs). However, US-based technique has not been univer…
View article: A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus
A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus Open
Chikungunya virus (CHIKV) infection causes acute disease characterized by fever, rash and arthralgia, which progresses to severe and chronic arthritis in up to 50% of patients. Moreover, CHIKV infection can be fatal in infants or immunocom…
View article: Incidence of carditis and predictors of pacemaker implantation in patients hospitalized with Lyme disease
Incidence of carditis and predictors of pacemaker implantation in patients hospitalized with Lyme disease Open
Background Lyme carditis, defined as direct infection of cardiac tissue by Borrelia bacteria, affects up to 10% of patients with Lyme disease. The most frequently reported clinical manifestation of Lyme carditis is cardiac conduction syste…
View article: Replication Data for: Gelatin Methacryloyl Bioadhesive Improves Survival and Reduces Scar Burden in a Mouse Model of Myocardial Infarction
Replication Data for: Gelatin Methacryloyl Bioadhesive Improves Survival and Reduces Scar Burden in a Mouse Model of Myocardial Infarction Open
Replication data related to publication: Ptaszek et al., J Am Heart Assoc. 2020;9:e014199. DOI: 10.1161/JAHA.119.014199
View article: Gelatin Methacryloyl Bioadhesive Improves Survival and Reduces Scar Burden in a Mouse Model of Myocardial Infarction
Gelatin Methacryloyl Bioadhesive Improves Survival and Reduces Scar Burden in a Mouse Model of Myocardial Infarction Open
Background Delivery of hydrogels to the heart is a promising strategy for mitigating the detrimental impact of myocardial infarction ( MI ). Challenges associated with the in vivo delivery of currently available hydrogels have limited clin…
View article: Impact of a Multidisciplinary Treatment Pathway for Atrial Fibrillation in the Emergency Department on Hospital Admissions and Length of Stay: Results of a Multi-Center Study.
Impact of a Multidisciplinary Treatment Pathway for Atrial Fibrillation in the Emergency Department on Hospital Admissions and Length of Stay: Results of a Multi-Center Study. Open
Impact of a Multidisciplinary Treatment Pathway for Atrial Fibrillation in the Emergency Department on Hospital Admissions and Length of Stay: Results of a Multi-Center Study. Ptaszek LM, Baugh CW, Lubitz SA, Ruskin JN, Ha G, Forsch M, DeO…
View article: Impact of a Multidisciplinary Treatment Pathway for Atrial Fibrillation in the Emergency Department on Hospital Admissions and Length of Stay: Results of a Multi‐Center Study
Impact of a Multidisciplinary Treatment Pathway for Atrial Fibrillation in the Emergency Department on Hospital Admissions and Length of Stay: Results of a Multi‐Center Study Open
Background Variability in the management of atrial fibrillation ( AF ) in the emergency department ( ED ) leads to avoidable hospital admissions and prolonged length of stay ( LOS ). In a retrospective single‐center study, a multidisciplin…
View article: ACT_DataSummary_17Jul2019lmp.xlsx
ACT_DataSummary_17Jul2019lmp.xlsx Open
Impact of a Multidisciplinary Treatment Pathway for Atrial Fibrillation in the Emergency Department on Hospital Admissions and Length of Stay: Results of a Multi-Center Study.
View article: 3D Bioprinting: Patient‐Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds (Adv. Healthcare Mater. 11/2018)
3D Bioprinting: Patient‐Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds (Adv. Healthcare Mater. 11/2018) Open
In article 1701347 by Ali Tamayol and co-workers, alginate-based bioinks are developed that carry platelet rich plasma (PRP) as a source of growth factors and are compatible with commercial bioprinters. The use of autologous PRP in the bio…
View article: Patient‐Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds
Patient‐Specific Bioinks for 3D Bioprinting of Tissue Engineering Scaffolds Open
Bioprinting has emerged as a promising tool in tissue engineering and regenerative medicine. Various 3D printing strategies have been developed to enable bioprinting of various biopolymers and hydrogels. However, the incorporation of biolo…
View article: Safety and efficacy of delivering high-power short-duration radiofrequency ablation lesions utilizing a novel temperature sensing technology
Safety and efficacy of delivering high-power short-duration radiofrequency ablation lesions utilizing a novel temperature sensing technology Open
Delivery of high-power short-duration RF energy applications, facilitated by a novel ablation catheter system equipped with advanced TC technology, is feasible, safe, and results in the formation of effective ablation lesions.
View article: Quantitative in vivo mapping of myocardial mitochondrial membrane potential
Quantitative in vivo mapping of myocardial mitochondrial membrane potential Open
We have analyzed the factors affecting the uptake of voltage sensing tracers and developed a minimally invasive method for mapping ΔΨT in left ventricular myocardium of pigs. ΔΨT is computed in absolute units, allowing for visual and stati…
View article: Rapid computation of single <scp>PET</scp> scan rest‐stress myocardial blood flow parametric images by table look up
Rapid computation of single <span>PET</span> scan rest‐stress myocardial blood flow parametric images by table look up Open
Purpose We have recently reported a method for measuring rest‐stress myocardial blood flow ( MBF ) using a single, relatively short, PET scan session. The method requires two IV tracer injections, one to initiate rest imaging and one at pe…
View article: Management of atrial fibrillation in patients taking targeted cancer therapies
Management of atrial fibrillation in patients taking targeted cancer therapies Open
Atrial fibrillation (AF) is frequently observed in patients being treated for cancer and can lead to increased morbidity and mortality in this population. With the use of newer, targeted cancer therapies, several drug-drug interactions hav…