Léon Sanche
YOU?
Author Swipe
View article: Development and In Vitro Evaluation of [64Cu]Cu-NOTA-TP-PSMA, a Novel Radiotheranostic Agent Against Prostate Cancer
Development and In Vitro Evaluation of [64Cu]Cu-NOTA-TP-PSMA, a Novel Radiotheranostic Agent Against Prostate Cancer Open
Prostate cancer (PCa), particularly in its metastatic form, remains a major clinical challenge due to limited diagnostic and therapeutic options. To address this, we developed a novel radiotheranostic agent, [64Cu]Cu-NOTA-TP-PSMA, by conju…
View article: Hyperthermal Reactions in DNA Triggered by 1–20 eV Electrons: Absolute Cross Sections for Crosslinks, Strand Breaks, Clustered Damages and Base Modifications
Hyperthermal Reactions in DNA Triggered by 1–20 eV Electrons: Absolute Cross Sections for Crosslinks, Strand Breaks, Clustered Damages and Base Modifications Open
Absolute cross sections (ACSs) are needed to estimate cellular damage induced by high-energy radiation (HER). Low-energy electrons (LEEs), which are the most numerous secondary particles generated by HER, can trigger hyperthermal reactions…
View article: Integrating Biochemical and Computational Approaches Reveal Structural Insights in Trastuzumab scFv-Fc Antibody Engineering
Integrating Biochemical and Computational Approaches Reveal Structural Insights in Trastuzumab scFv-Fc Antibody Engineering Open
Antibody-based agents have become a preferred treatment for various diseases, including cancer, due to significant advances in antibody engineering. The use of single-chain Fv-Fcs (scFv-Fcs) has been a promising engineering approach for th…
View article: Influence of a Xenon interlayer on dissociative electron attachment to deuterated methane on a platinum substrate
Influence of a Xenon interlayer on dissociative electron attachment to deuterated methane on a platinum substrate Open
We investigate the impact of intercalating a xenon layer between a thin condensed CD4 film of two monolayers (ML) and a platinum surface on the dissociative electron attachment (DEA). The observed desorption results are compared with densi…
View article: Hyperthermal Reactions in DNA Triggered by 1-20 eV Electrons: Absolute Cross Sections for Crosslinks, Strand Breaks, Clustered Damages and Base Modifications
Hyperthermal Reactions in DNA Triggered by 1-20 eV Electrons: Absolute Cross Sections for Crosslinks, Strand Breaks, Clustered Damages and Base Modifications Open
Absolute cross sections (ACSs) are needed to estimate cellular damage induced by high energy radiation (HER). Low-energy electrons (LEEs), which are the most numerous secondary particles generated by HER, can trigger hyperthermal reactions…
View article: Oxygen Effect on 0–30 eV Electron Damage to DNA Under Different Hydration Levels: Base and Clustered Lesions, Strand Breaks and Crosslinks
Oxygen Effect on 0–30 eV Electron Damage to DNA Under Different Hydration Levels: Base and Clustered Lesions, Strand Breaks and Crosslinks Open
Studies on radiosensitization of biological damage by O2 began about a century ago and it remains one of the most significant subjects in radiobiology. It has been related to increased production of oxygen radicals and other reactive metab…
View article: How a Single 5 eV Electron Can Induce Double-Strand Breaks in DNA: A Time-Dependent Density Functional Theory Study
How a Single 5 eV Electron Can Induce Double-Strand Breaks in DNA: A Time-Dependent Density Functional Theory Study Open
Low-energy (4 groups at the C5' sites of ds[5'-G-3']. The first σ* state at 1 eV is due to a shape resonance, while the second σ* state is induced by a core-excited resonance at 5.4 eV. As the bond of the latter state stretches and arrives…
View article: Electron stimulated desorption from condensed benzene
Electron stimulated desorption from condensed benzene Open
Electron induced dissociation of condensed benzene (C 6 H 6 ) in thin films on a Pt substrate is investigated by the electron stimulated desorption of anions and cations. Desorption yields and effective dipolar dissociation cross-sections …
View article: Mechanisms of Nanoscale Radiation Enhancement by Metal Nanoparticles: Role of Low Energy Electrons
Mechanisms of Nanoscale Radiation Enhancement by Metal Nanoparticles: Role of Low Energy Electrons Open
Metal nanoparticles are considered as highly promising radiosensitizers in cancer radiotherapy. Understanding their radiosensitization mechanisms is critical for future clinical applications. This review is focused on the initial energy de…
View article: In vivo behavior of [64Cu]NOTA-terpyridine platinum, a novel chemo-radio-theranostic agent for imaging, and therapy of colorectal cancer
In vivo behavior of [64Cu]NOTA-terpyridine platinum, a novel chemo-radio-theranostic agent for imaging, and therapy of colorectal cancer Open
To overcome resistance to chemotherapy for colorectal cancer, we propose to validate in vivo a novel terpyridine-platinum (TP) compound radiolabeled with the radio-theranostic isotope 64 Cu. In vivo stability, biodistribution, PET imaging,…
View article: Estimation of the Internal Dose Imparted by 18F-Fluorodeoxyglucose to Tissues by Using Fricke Dosimetry in a Phantom and Positron Emission Tomography
Estimation of the Internal Dose Imparted by 18F-Fluorodeoxyglucose to Tissues by Using Fricke Dosimetry in a Phantom and Positron Emission Tomography Open
Purpose Assessment of the radiation dose delivered to a tumor and different organs is a major issue when using radiolabelled compounds for diagnostic imaging or endoradiotherapy. The present article reports on a study to correlate the mean…
View article: Damage Induced to DNA and Its Constituents by 0–3 eV UV Photoelectrons<sup>†</sup>
Damage Induced to DNA and Its Constituents by 0–3 eV UV Photoelectrons<sup>†</sup> Open
The complex physical and chemical interactions between DNA and 0–3 eV electrons released by UV photoionization can lead to the formation of various lesions such as base modifications and cleavage, crosslinks and single strand breaks. Furth…
View article: Design, Synthesis, and Cytotoxicity Assessment of [64Cu]Cu-NOTA-Terpyridine Platinum Conjugate: A Novel Chemoradiotherapeutic Agent with Flexible Linker
Design, Synthesis, and Cytotoxicity Assessment of [64Cu]Cu-NOTA-Terpyridine Platinum Conjugate: A Novel Chemoradiotherapeutic Agent with Flexible Linker Open
Maximum benefits of chemoradiation therapy with platinum-based compounds are expected if the radiation and the drug are localized simultaneously in cancer cells. To optimize this concomitant effect, we developed the novel chemoradiotherape…
View article: Low-Energy Electron Damage to Condensed-Phase DNA and Its Constituents
Low-Energy Electron Damage to Condensed-Phase DNA and Its Constituents Open
The complex physical and chemical reactions between the large number of low-energy (0–30 eV) electrons (LEEs) released by high energy radiation interacting with genetic material can lead to the formation of various DNA lesions such as cros…
View article: The Cytotoxic Effect of 64Cu/NOTA-Terpyridine Platinum Conjugate, as a Novel Chemoradiotherapy Agent
The Cytotoxic Effect of 64Cu/NOTA-Terpyridine Platinum Conjugate, as a Novel Chemoradiotherapy Agent Open
Colorectal cancer is one of the most prevalent cancers worldwide that displays both intrinsic and acquired resistance to platinum-based chemotherapeutic agents (Pt-CAs). To overcome such resistance, new classes of Pt-CAs have been proposed…
View article: Concomitant Chemoradiation Therapy with Gold Nanoparticles and Platinum Drugs Co-Encapsulated in Liposomes
Concomitant Chemoradiation Therapy with Gold Nanoparticles and Platinum Drugs Co-Encapsulated in Liposomes Open
A liposomal formulation of gold nanoparticles (GNPs) and carboplatin, named LipoGold, was produced with the staggered herringbone microfluidic method. The radiosensitizing potential of LipoGold and similar concentrations of non-liposomal G…
View article: Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions
Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions Open
This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential …
View article: Hydrated electrons induce the formation of interstrand cross-links in DNA modified by cisplatin adducts
Hydrated electrons induce the formation of interstrand cross-links in DNA modified by cisplatin adducts Open
Double-stranded oligonucleotides containing cisplatin adducts, with and without a mismatched region, were exposed to hydrated electrons generated by gamma-rays. Gel electrophoresis analysis demonstrates the formation of cisplatin-interstra…
View article: Absolute vibrational and electronic cross sections for low-energy electron scattering from condensed Thymidine
Absolute vibrational and electronic cross sections for low-energy electron scattering from condensed Thymidine Open
Synopsis Absolute vibrational and electronic excitation cross sections (CSs) for low-energy electrons (1-18 eV) scattering from condensed thymidine (dT) are measured with High-Resolution Electron Energy Loss Spectros-copy (HREELS). EEL spe…
View article: DNA damage in Thymidyl(3<sup>’</sup>-5<sup>’</sup>)thymidine (TpT) induced by very low energy electrons
DNA damage in Thymidyl(3<sup>’</sup>-5<sup>’</sup>)thymidine (TpT) induced by very low energy electrons Open
Synopsis The interaction of high-energy radiation with the biological matter produces copious amounts of non-thermal secondary low energy electrons (LEEs; 0-30 eV). Several studies have shown that 5-15 eV electrons induce different types o…
View article: Low energy electron induced chemistry in CO<sub>2</sub>:NH<sub>3</sub>:CH<sub>4</sub> ices
Low energy electron induced chemistry in CO<sub>2</sub>:NH<sub>3</sub>:CH<sub>4</sub> ices Open
Synopsis We report measurements of the electron stimulated desorption of anions from thin (nanometer scale) films of CO 2 , NH 3 , CH 4 , and mixtures thereof.
View article: <p>Increased radiosensitivity of colorectal tumors with intra-tumoral injection of low dose of gold nanoparticles [Corrigendum]</p>
Increased radiosensitivity of colorectal tumors with intra-tumoral injection of low dose of gold nanoparticles [Corrigendum] Open
[This corrects the article DOI: 10.2147/IJN.S97541.].
View article: Clustered DNA Damages induced by 0.5 to 30 eV Electrons
Clustered DNA Damages induced by 0.5 to 30 eV Electrons Open
Low-energy electrons (LEEs) of energies ≤30 eV are generated in large quantities by ionizing radiation. These electrons can damage DNA; particularly, they can induce the more detrimental clustered lesions in cells. This type of lesions, wh…
View article: Roadmap on photonic, electronic and atomic collision physics: II. Electron and antimatter interactions
Roadmap on photonic, electronic and atomic collision physics: II. Electron and antimatter interactions Open
We publish three Roadmaps on photonic, electronic and atomic collision physics in order to celebrate the 60th anniversary of the ICPEAC conference. In Roadmap II we focus on electron and antimatter interactions. Modern theoretical and expe…
View article: Convection-Enhanced Delivery in Malignant Gliomas: A Review of Toxicity and Efficacy
Convection-Enhanced Delivery in Malignant Gliomas: A Review of Toxicity and Efficacy Open
Malignant gliomas are undifferentiated or anaplastic gliomas. They remain incurable with a multitude of modalities, including surgery, radiation, chemotherapy, and alternating electric field therapy. Convection-enhanced delivery (CED) is a…
View article: Elucidation of the Two-Step Damage Formation Process of Latent Tracks in Poly(allyl diglycol carbonate), PADC: Role of Secondary Low-Energy Electrons
Elucidation of the Two-Step Damage Formation Process of Latent Tracks in Poly(allyl diglycol carbonate), PADC: Role of Secondary Low-Energy Electrons Open
International audience
View article: Development and optimization of an injectable formulation of copper diethyldithiocarbamate, an active anticancer agent
Development and optimization of an injectable formulation of copper diethyldithiocarbamate, an active anticancer agent Open
Copper diethyldithiocarbamate (Cu(DDC)2) is the active anticancer agent generated when disulfiram (DSF) is provided in the presence of copper. To date, research directed toward repurposing DSF as an anticancer drug has focused on administr…