Leon Tribolet
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View article: Identification of a novel role for the immunomodulator ILRUN in the development of several T cell subsets in mice
Identification of a novel role for the immunomodulator ILRUN in the development of several T cell subsets in mice Open
Inflammation and lipid regulator with UBA-like and NBR1-like domains (ILRUN) is a protein-encoding gene associated with innate immune signaling, lipid metabolism and cancer. In the context of innate immunity, ILRUN inhibits IRF3-mediated t…
View article: Hookworm Na-ASP-2 - putative functions, allergenicity and implications for vaccine development
Hookworm Na-ASP-2 - putative functions, allergenicity and implications for vaccine development Open
Necator americanus is one of several hookworms that infect humans. The other notable species are Ancylostoma duodenale and Ancylostoma ceylanicum. Hookworms infect approximately 540-730 million people worldwide with more than a billion at …
View article: ILRUN Downregulates ACE2 Expression and Blocks Infection of Human Cells by SARS-CoV-2
ILRUN Downregulates ACE2 Expression and Blocks Infection of Human Cells by SARS-CoV-2 Open
There is no doubt that the current rapid global spread of COVID-19 has had significant and far-reaching impacts on our health and economy and will continue to do so. Research in emerging infectious diseases, such as severe acute respirator…
View article: Ribosome-Profiling Reveals Restricted Post Transcriptional Expression of Antiviral Cytokines and Transcription Factors during SARS-CoV-2 Infection
Ribosome-Profiling Reveals Restricted Post Transcriptional Expression of Antiviral Cytokines and Transcription Factors during SARS-CoV-2 Infection Open
The global COVID-19 pandemic caused by SARS-CoV-2 has resulted in over 2.2 million deaths. Disease outcomes range from asymptomatic to severe with, so far, minimal genotypic change to the virus so understanding the host response is paramou…
View article: Ribosome-profiling reveals restricted post transcriptional expression of antiviral cytokines and transcription factors during SARS-CoV-2 infection
Ribosome-profiling reveals restricted post transcriptional expression of antiviral cytokines and transcription factors during SARS-CoV-2 infection Open
The global COVID-19 pandemic caused by SARS-CoV-2 has resulted in over 2.2 million deaths. Disease outcomes range from asymptomatic to severe with, so far, minimal genotypic change to the virus so understanding the host response is paramou…
View article: Investigating the Interaction between Negative Strand RNA Viruses and Their Hosts for Enhanced Vaccine Development and Production
Investigating the Interaction between Negative Strand RNA Viruses and Their Hosts for Enhanced Vaccine Development and Production Open
The current pandemic has highlighted the ever-increasing risk of human to human spread of zoonotic pathogens. A number of medically-relevant zoonotic pathogens are negative-strand RNA viruses (NSVs). NSVs are derived from different virus f…
View article: ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2
ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2 Open
The human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domain, previously C6orf106) is a recently-characterised inhibitor of the transcription regulators p300 and CREB-binding protein (CBP). Here …
View article: MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing
MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing Open
In the pursuit of improved diagnostic tests for infectious diseases, several classes of molecules have been scrutinized as prospective biomarkers. Small (18-22 nucleotide), non-coding RNA transcripts called microRNAs (miRNAs) have emerged …
View article: Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines
Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines Open
Regulation of type-I interferon (IFN) production is essential to the balance between antimicrobial defence and autoimmune disorders. The human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains,…
View article: mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans
mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans Open
The cellular origins of glomerulosclerosis involve activation of parietal epithelial cells (PECs) and progressive podocyte depletion. While mammalian target of rapamycin-mediated (mTOR-mediated) podocyte hypertrophy is recognized as an imp…
View article: The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells
The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells Open
Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in the venom and target ionotropic glutamate receptors. Here we show that a novel sp…