Leonard Cheung
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View article: OR13-04 Nucleoredoxin Regulates WNT Signaling During Pituitary Stem Cell Differentiation
OR13-04 Nucleoredoxin Regulates WNT Signaling During Pituitary Stem Cell Differentiation Open
Disclosure: M.L. Brinkmeier: None. S. Yang: None. L.Y. Cheung: None. S.P. O'Connell: None. D.K. Gutierrez: None. Y. Ho: None. E.C. Rhoads: None. S.A. Camper: None. S.W. Davis: None. Nucleoredoxin (Nxn) encodes a multi-functional enzyme wit…
View article: Myelin regulatory factor (MYRF) is a critical early regulator of retinal pigment epithelial development
Myelin regulatory factor (MYRF) is a critical early regulator of retinal pigment epithelial development Open
Myelin regulatory factor (Myrf) is a critical transcription factor in early retinal and retinal pigment epithelial development, and human variants in MYRF are a cause for nanophthalmos. Single cell RNA sequencing (scRNAseq) was performed o…
View article: Nucleoredoxin regulates WNT signaling during pituitary stem cell differentiation
Nucleoredoxin regulates WNT signaling during pituitary stem cell differentiation Open
Nucleoredoxin (Nxn) encodes a multi-functional enzyme with oxidoreductase activity that regulates many different signaling pathways and cellular processes in a redox-dependent manner. Rare NXN mutations are reported in individuals with rec…
View article: Nucleoredoxin regulates WNT signaling during pituitary stem cell differentiation
Nucleoredoxin regulates WNT signaling during pituitary stem cell differentiation Open
Nucleoredoxin ( Nxn ) encodes a multi-functional enzyme with oxidoreductase activity that regulates many different signaling pathways and cellular processes in a redox-dependent manner. Rare NXN mutations are reported in individuals with r…
View article: Long Noncoding RNAs Expressed in Mouse Pituitary Development and Mature Hormone-Producing Cells
Long Noncoding RNAs Expressed in Mouse Pituitary Development and Mature Hormone-Producing Cells Open
Mammalian genomes contain thousands of genes for long noncoding RNA (lncRNAs), some of which have been shown to affect protein coding gene expression through diverse mechanisms. The lncRNA transcripts are longer than 200 nucleotides and ar…
View article: Gene Misexpression in a <i>Smoc2</i>+ve/<i>Sox2</i>-Low Population in Juvenile <i>Prop1</i>-Mutant Pituitary Gland
Gene Misexpression in a <i>Smoc2</i>+ve/<i>Sox2</i>-Low Population in Juvenile <i>Prop1</i>-Mutant Pituitary Gland Open
Mutations in the pituitary-specific transcription factor Prophet of Pit-1 (PROP1) are the most common genetic etiology of combined pituitary hormone deficiency (CPHD). CPHD is associated with short stature, attributable to growth hormone d…
View article: Knockout mice with pituitary malformations help identify human cases of hypopituitarism
Knockout mice with pituitary malformations help identify human cases of hypopituitarism Open
Background Congenital hypopituitarism (CH) and its associated syndromes, septo-optic dysplasia (SOD) and holoprosencephaly (HPE), are midline defects that cause significant morbidity for affected people. Variants in 67 genes are associated…
View article: <i>Myelin regulatory factor</i>(<i>Myrf</i>) is a critical early regulator of retinal pigment epithelial development
<i>Myelin regulatory factor</i>(<i>Myrf</i>) is a critical early regulator of retinal pigment epithelial development Open
Myelin regulatory factor (Myrf) is a critical transcription factor in early retinal and retinal pigment epithelial development, and human variants in MYRF are a cause for nanophthalmos. Single cell RNA sequencing (scRNAseq) was performed o…
View article: Editorial: New advances on hypothalamus-pituitary stem cell biology
Editorial: New advances on hypothalamus-pituitary stem cell biology Open
Citation: Cheung L, Davis SW and Perez-Millan MI (2024) Editorial: New advances on hypothalamus-pituitary stem cell biology. Front. Endocrinol. 15:1392076. doi: 10.3389/fendo.2024.1392076
View article: THU119 Screening Publicly Available Data To Identify Candidate Genes For Congenital Hypopituitarism
THU119 Screening Publicly Available Data To Identify Candidate Genes For Congenital Hypopituitarism Open
Disclosure: M.L. Brinkmeier: None. J.J. Martínez Mayer: None. B.S. Ellsworth: None. L.T. Raetzman: None. L. Cheung: None. M.I. Perez-Millan: None. S.A. Camper: None. S.W. Davis: None. Congenital hypopituitarism (CH) and its associated synd…
View article: OR17-02 Combining Transcriptomics And Proteomics To Unveil Possible PROP1 Interactors During Embryonic Pituitary Development
OR17-02 Combining Transcriptomics And Proteomics To Unveil Possible PROP1 Interactors During Embryonic Pituitary Development Open
Disclosure: L. Iglesias Garcia: None. M.F. Mercogliano: None. C. Schuster: None. L. Cheung: None. S.A. Camper: None. M. Marti: None. M.I. Perez-Millan: None. Congenital hypopituitarism (CH) is a deficiency of one or more hormones produced …
View article: Novel Candidate Regulators and Developmental Trajectory of Pituitary Thyrotropes
Novel Candidate Regulators and Developmental Trajectory of Pituitary Thyrotropes Open
The pituitary gland regulates growth, metabolism, reproduction, the stress response, uterine contractions, lactation, and water retention. It secretes hormones in response to hypothalamic input, end organ feedback, and diurnal cues. The me…
View article: RF13 | PMON142 Long Non-coding RNAs in Pituitary Differentiation and Endocrine Function
RF13 | PMON142 Long Non-coding RNAs in Pituitary Differentiation and Endocrine Function Open
Mammalian genomes contain thousands of genes for long non-coding RNA (lncRNAs) that affect the expression of other genes through diverse mechanisms. The lncRNA transcripts are longer than 200 nucleotides and are often capped, spliced and p…
View article: PMON145 The Role of Pou3f4 in Pituitary Development and Disease
PMON145 The Role of Pou3f4 in Pituitary Development and Disease Open
Mutations in the pituitary specific transcription factor Prophet of Pit-1 (PROP1) are the most common genetic etiology of combined pituitary hormone deficiency (CPHD), which affects 1 in 8,000 newborns worldwide. CPHD is associated with sh…
View article: Endocrine and behavioural features of Lowe syndrome and their potential molecular mechanisms
Endocrine and behavioural features of Lowe syndrome and their potential molecular mechanisms Open
Background Lowe syndrome (LS) is an X linked disease caused by pathogenic variants in the OCRL gene that impacts approximately 1 in 500 000 children. Classic features include congenital cataract, cognitive/behavioural impairment and renal …
View article: Single-Cell Gene Expression Analysis Reveals Gene Regulatory Networks Driving Proliferation in Pituitary Stem and Endocrine Cells
Single-Cell Gene Expression Analysis Reveals Gene Regulatory Networks Driving Proliferation in Pituitary Stem and Endocrine Cells Open
A fundamental question for pituitary development and disease is to understand the mechanisms that regulate proliferation, quiescence, and differentiation of stem cells and endocrine lineage-committed precursor cells. Pituitary stem cells, …
View article: Cell population characterization and discovery using single-cell technologies in endocrine systems
Cell population characterization and discovery using single-cell technologies in endocrine systems Open
In the last 15 years, single-cell technologies have become robust and indispensable tools to investigate cell heterogeneity. Beyond transcriptomic, genomic and epigenome analyses, technologies are constantly evolving, in particular toward …
View article: OR16-05 Single-Cell Sequencing Identifies Novel Regulators of Thyrotrope Populations and POU1F1-Independent Thyroid-Stimulating Hormone Expression
OR16-05 Single-Cell Sequencing Identifies Novel Regulators of Thyrotrope Populations and POU1F1-Independent Thyroid-Stimulating Hormone Expression Open
We implemented single-cell RNA sequencing (scRNAseq) technology as a discovery tool to identify factors enriched in differentiated thyrotropes. Thyroid-stimulating hormone (TSH) is produced in the pars distalis of the anterior pituitary (A…
View article: MON-715 How Heterogeneous Are Pituitary Thyrotropes?
MON-715 How Heterogeneous Are Pituitary Thyrotropes? Open
Many transcription factors have been identified that are important for specification and differentiation of the hormone-producing cells of the pituitary gland. For example, POU1F1 is essential for differentiation of thyrotropes, somatotrop…
View article: MON-723 Identification of Thyrotrope Signature Genes and Regulatory Elements
MON-723 Identification of Thyrotrope Signature Genes and Regulatory Elements Open
Recent genome wide association studies have begun to identify loci that are risk factors for sporadic pituitary adenomas, but the genes associated with these loci are unknown. In general, ~90% of GWAS hits are in noncoding regions, making …
View article: PROP1-Dependent Retinoic Acid Signaling Regulates Developmental Pituitary Morphogenesis and Hormone Expression
PROP1-Dependent Retinoic Acid Signaling Regulates Developmental Pituitary Morphogenesis and Hormone Expression Open
Dietary vitamin A is metabolized into bioactive retinoic acid (RA) in vivo and regulates the development of many embryonic tissues. RA signaling is active in the oral ectoderm-derived tissues of the neuroendocrine system, but its role ther…
View article: Single-Cell RNA Sequencing Reveals Novel Markers of Male Pituitary Stem Cells and Hormone-Producing Cell Types
Single-Cell RNA Sequencing Reveals Novel Markers of Male Pituitary Stem Cells and Hormone-Producing Cell Types Open
Transcription factors and signaling pathways that regulate stem cells and specialized hormone-producing cells in the pituitary gland have been the subject of intense study and have yielded a mechanistic understanding of pituitary organogen…
View article: NOTCH activity differentially affects alternative cell fate acquisition and maintenance
NOTCH activity differentially affects alternative cell fate acquisition and maintenance Open
The pituitary is an essential endocrine gland regulating multiple processes. Regeneration of endocrine cells is of therapeutic interest and recent studies are promising, but mechanisms of endocrine cell fate acquisition need to be better c…
View article: Author response: NOTCH activity differentially affects alternative cell fate acquisition and maintenance
Author response: NOTCH activity differentially affects alternative cell fate acquisition and maintenance Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract The pituitary is an essential endocrine gland regulating mul…
View article: Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era
Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era Open
The genetic basis for combined pituitary hormone deficiency (CPHD) is complex, involving 30 genes in a variety of syndromic and nonsyndromic presentations. Molecular diagnosis of this disorder is valuable for predicting disease progression…
View article: LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A) Causes Growth Insufficiency and Male Infertility in Mice
LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A) Causes Growth Insufficiency and Male Infertility in Mice Open
Skeletal dysplasias are a common, genetically heterogeneous cause of short stature that can result from disruptions in many cellular processes. We report the identification of the lesion responsible for skeletal dysplasia and male infertil…