Leonard E. Bäcker
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The infection cycle of the haloarchaeal virus HFTV1 is tightly regulated and strongly inhibits motility of its host Open
Although viruses have been shown to infect all domains of life, our understanding of the genetic program behind the exploitation of host resources to produce progeny virions is thus far limited to several bacterial viruses. Therefore, to e…
Phage-mediated just-in-time circuit amplification and delivery for recombinant expression of toxic proteins Open
In order to address outstanding challenges in bacterial bioreactor bioprocessing, we have developed an approach that alleviates the need for chemical inducers and selective agents (such as antibiotics), and mitigates leaky expression of th…
The infection cycle of the haloarchaeal virus HFTV1 is tightly regulated and strongly inhibits motility of its host Open
Although viruses have been shown to infect all domains of life, our understanding of the genetic program behind the exploitation of host resources to produce progeny virions is thus far limited to several bacterial viruses. Therefore, to e…
View article: Tuning and functionalization of logic gates for time resolved programming of bacterial populations
Tuning and functionalization of logic gates for time resolved programming of bacterial populations Open
In order to increase our command over genetically engineered bacterial populations in bioprocessing and therapy, synthetic regulatory circuitry needs to enable the temporal programming of a number of consecutive functional tasks without ex…
View article: Tuning and functionalization of logic gates for time resolved programming of bacterial populations
Tuning and functionalization of logic gates for time resolved programming of bacterial populations Open
In order to increase our command over genetically engineered bacterial populations in bioprocessing and therapy, synthetic regulatory circuitry needs to enable the temporal programming of a number of consecutive functional tasks without ex…
The potential of bacteriophages to control <i>Xanthomonas campestris</i> pv. <i>campestris</i> at different stages of disease development Open
Summary Xanthomonas campestris pv. campestris (Xcc) is a vascular pathogen that invades the xylem of Brassica crops. Current chemical and antibiotics‐based control measures for this bacterium are unsustainable and inefficient. After establ…
Transcriptional Organization of the Salmonella Typhimurium Phage P22 pid ORFan Locus Open
Many phage genes lack sequence similarity to any other open reading frame (ORF) in current databases. These enigmatic ORFan genes can have a tremendous impact on phage propagation and host interactions but often remain experimentally unexp…
Quantification of microbial degradation activities in biological activated carbon filters by reverse stable isotope labelling Open
Biological activated carbon (BAC) filters are frequently used in drinking water production for removing dissolved organic carbon (DOC) via adsorption of organic compounds and microbial degradation. However, proper methods are still missing…
Monitoring Microbial Mineralization Using Reverse Stable Isotope Labeling Analysis by Mid-Infrared Laser Spectroscopy Open
Assessing the biodegradation of organic compounds is a frequent question in environmental science. Here, we present a sensitive, inexpensive, and simple approach to monitor microbial mineralization using reverse stable isotope labeling ana…
Monitoring Microbial Mineralization Using Reverse Stable Isotope Labeling Analysis by Mid-Infrared Laser Spectroscopy Open
Development of a new method to measure mineralization of organic carbon adsorbed to granular activated carbon in water production