Explanipedia

DNA shuffling to improve crude-water interfacial activity in biosurfactants with OmpA protein of <i>Escherichia coli</i> Open

Vanessa Lucía Núñez Vélez, Laurent Gomez, Jhon E. Mendoza Ospina, Yasser Hayek-Orduz, Miguel Fernández‐Niño , et al. · 2024

Surfactants are molecules derived primarily from petroleum that can reduce the surface tension at interfaces. Their slow degradation is a characteristic that could cause environmental issues. This and other factors contribute to the allure…

Biodose Tools: an R shiny application for biological dosimetry Open

A. Hernandez, David Endesfelder, Jochen Einbeck, Pedro Puig, Mohamed Amine Benadjaoud , et al. · 2023

In the event of a radiological accident or incident, the aim of biological dosimetry is to convert the yield of a specific biomarker of exposure to ionizing radiation into an absorbed dose. Since the 1980s, various tools have been used to …

Biodose Tools: An R shiny Application for Biological Dosimetry Open

A. Hernandez, David Endesfelder, Jochen Einbeck, Pedro Puig, Mohamed Amine Benadjaoud , et al. · 2023

Introduction In the event of a radiological accident or incident, the aim of biological dosimetry is to convert the yield of a specific biomarker of exposure to ionizing radiation into an absorbed dose. Since the 1980s, various tool…

Biodose Tools: an R shiny application for biological dosimetry Open

A. Hernandez, David Endesfelder, Jochen Einbeck, Pedro Puig, Mohamed Amine Benadjaoud , et al. · 2023

In the event of a radiological accident or incident, the aim of biological dosimetry is to convert the yield of a specific biomarker of exposure to ionizing radiation into an absorbed dose. Since the 1980s, various tools have been used to …

Differential Radiosensitizing Effect of 50 nm Gold Nanoparticles in Two Cancer Cell Lines Open

Miguel Ángel Pérez-Amor, Leonardo Barrios, Gemma Armengol, Joan Francesc Barquinero · 2022

Radiation therapy is widely used as an anti-neoplastic treatment despite the adverse effects it can cause in non-tumoral tissues. Radiosensitizing agents, which can increase the effect of radiation in tumor cells, such as gold nanoparticle…

The Slashed Power Half-Normal Distribution with Applications Open

Leonardo Barrios, Yolanda M. Gómez, Osvaldo Venegas, Inmaculada Barranco‐Chamorro, Héctor W. Gómez · 2022

In this paper, an extension of the power half-normal (PHN) distribution is introduced. This new model is built on the application of slash methodology for positive random variables. The result is a distribution with greater kurtosis than t…

Imaging luminescent tattoo inks for direct visualization of linac and cobalt irradiation Open

Ethan P. M. LaRochelle, Jennifer Soter, Leonardo Barrios, Marysia Guzmán, Samuel S. Streeter , et al. · 2020

Purpose Tattoo fiducials are commonly used in radiotherapy patient alignment, and recent studies have examined the use of UV‐excited luminescent tattoo ink as a cosmetic substitute to make these visible under UV illumination. The goal of t…

Cell Internalization in Fluidic Culture Conditions Is Improved When Microparticles Are Specifically Targeted to the Human Epidermal Growth Factor Receptor 2 (HER2) Open

Inmaculada Mora-Espí, Elena Ibáñez, Jorge Soriano, Carme Nogués, Þórarinn Guðjónsson , et al. · 2019

Purpose: To determine if the specific targeting of microparticles improves their internalization by cells under fluidic conditions. Methods: Two isogenic breast epithelial cell lines, one overexpressing the Human Epidermal Growth Factor Re…

Permanently hydrophilic, piezoelectric PVDF nanofibrous scaffolds promoting unaided electromechanical stimulation on osteoblasts Open

Μαρία Κιτσαρά, Andreu Blanquer, Gonzalo Murillo, Vincent Humblot, Sara de Bragança , et al. · 2019

Electrospinning and plasma post-modification lead to PVDF scaffolds with favorable electromechanical properties and enhanced wettability.

Membrane reorganization after photochemical internalization to release transferrin-biofunctionalized polystyrene microparticles Open

Inmaculada Mora-Espí, Leonardo Barrios, Elena Ibáñez, Jorge Soriano, Carme Nogués · 2018

Amphiphilic gemini pyridinium-mediated incorporation of Zn(II)meso-tetrakis(4-carboxyphenyl)porphyrin into water-soluble gold nanoparticles for photodynamic therapy Open

María E. Alea-Reyes, Jorge Soriano, Inmaculada Mora-Espí, Mafalda Rodrigues, David A. Russell , et al. · 2017

Mechanical properties, corrosion performance and cell viability studies on newly developed porous Fe-Mn-Si-Pd alloys Open

Yu Feng, Nerea Gaztelumendi, Jordina Fornell, H.Y. Zhang, P. Solsona , et al. · 2017

Biodegradable FeMnSi Sputter-Coated Macroporous Polypropylene Membranes for the Sustained Release of Drugs Open

Jordina Fornell, Jorge Soriano, Miguel Guerrero, Juan de Dios Sirvent, Marta Ferran-Marqués , et al. · 2017

Pure Fe and FeMnSi thin films were sputtered on macroporous polypropylene (PP) membranes with the aim to obtain biocompatible, biodegradable and, eventually, magnetically-steerable platforms. Room-temperature ferromagnetic response was obs…

Bioelectronics: Electromechanical Nanogenerator–Cell Interaction Modulates Cell Activity (Adv. Mater. 24/2017) Open

Gonzalo Murillo, Andreu Blanquer, Carolina Vargas‐Estevez, Leonardo Barrios, Elena Ibáñez , et al. · 2017

Saos-2 cells are cultured on top of piezoelectric nanogenerators (NGs) based on ZnO nanosheets for electrical self-stimulation by Gonzalo Murillo, Carme Nogués, and co-workers in article number 1605048. Imaging by scanning electron microsc…

Electromechanical Nanogenerator–Cell Interaction Modulates Cell Activity Open

Gonzalo Murillo, Andreu Blanquer, Carolina Vargas‐Estevez, Leonardo Barrios, Elena Ibáñez , et al. · 2017

Noninvasive methods for in situ electrical stimulation of human cells open new frontiers to future bioelectronic therapies, where controlled electrical impulses could replace the use of chemical drugs for disease treatment. Here, this stud…

Cytocompatibility assessment of Ti‐Zr‐Pd‐Si‐(Nb) alloys with low Young's modulus, increased hardness, and enhanced osteoblast differentiation for biomedical applications Open

Andreu Blanquer, Jana Musı́lková, Leonardo Barrios, Elena Ibáñez, Marta Vandrovcová , et al. · 2017

Ti‐based alloys have increased importance for biomedical applications due to their excellent properties. In particular, the two recently developed TiZrPdSi(Nb) alloys, with a predominant β‐Ti phase microstructure, have good mechanical prop…

Cell Death Mechanisms in Tumoral and Non-Tumoral Human Cell Lines Triggered by Photodynamic Treatments: Apoptosis, Necrosis and Parthanatos Open

Jorge Soriano, Inmaculada Mora-Espí, María E. Alea-Reyes, Lluïsa Pérez‐García, Leonardo Barrios , et al. · 2017

Cell death triggered by photodynamic therapy can occur through different mechanisms: apoptosis, necrosis or autophagy. However, recent studies have demonstrated the existence of other mechanisms with characteristics of both necrosis and ap…

The RENEB operational basis: complement of established biodosimetric assays Open

Andrzej Wójcik, Ursula Oestreicher, Leonardo Barrios, Anne Vral, Georgia I. Terzoudi , et al. · 2016

The RENEB network is fully operational and ready to act in case of a major radiation emergency. Moreover, the high capacity for analyzing radiation-induced damage in cells and personal electronic devices makes the network suitable for larg…

RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA) Open

Ursula Oestreicher, Daniel Samaga, Elizabeth A. Ainsbury, Ana Antunes, Ans Baeyens , et al. · 2016

In case of a large-scale radiological incident, the pooling of ressources by networks can enhance the rapid classification of individuals in medically relevant treatment groups based on the DCA. The performance of the RENEB network as a wh…

Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation Open

F. Trompier, M. Baumann, Leonardo Barrios, Eric Grégoire, Michael Abend , et al. · 2016

This work has shown the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and dosimetry practices and educational training for biologists using ionizing radiation.

RENEB – Running the European Network of biological dosimetry and physical retrospective dosimetry Open

Ulrike Kulka, Michael Abend, Elizabeth A. Ainsbury, Christophe Badie, Joan Francesc Barquinero , et al. · 2016

RENEB is a European Network of biological and physical-retrospective dosimetry, with the capacity and capability to perform large-scale rapid individualized dose estimation. Specialized to handle large numbers of samples, RENEB is able to …

RENEB biodosimetry intercomparison analyzing translocations by FISH Open

Joan Francesc Barquinero, Christina Beinke, Mireia Borràs, Iwona Buraczewska, F. Darroudi , et al. · 2016

The results obtained indicate that, despite the problems identified in few partners, which can be corrected, the RENEB consortium is able to carry out retrospective biodosimetry analyzing the frequency of translocations by FISH.

Uncertainty of fast biological radiation dose assessment for emergency response scenarios Open

Elizabeth A. Ainsbury, Manuel Higueras, Pedro Puig, Jochen Einbeck, Daniel Samaga , et al. · 2016

Finally, it is demonstrated that whatever uncertainty estimation method is employed, ignoring the uncertainty on fast dose assessments can have an important impact on rapid biodosimetric categorization.

RENEB accident simulation exercise Open

B. Brzozowska, Elizabeth A. Ainsbury, Annelot Baert, Lindsay A. Beaton-Green, Leonardo Barrios , et al. · 2016

Each participant received training in both the role of a reference laboratory (activating the network) and of a service laboratory (responding to an activation request). The procedures in the case of radiological event were successfully es…

Web based scoring is useful for validation and harmonisation of scoring criteria within RENEB Open

H. Romm, Elizabeth A. Ainsbury, Joan Francesc Barquinero, Leonardo Barrios, Christina Beinke , et al. · 2016

Overall, the web based scoring of the two galleries by the 17 laboratories produced very good results. Application of web based scoring for the dicentric assay may therefore be a relevant strategy for an operational biodosimetry assistance…

The harmonization process to set up and maintain an operational biological and physical retrospective dosimetry network: QA QM applied to the RENEB network Open

Eric Grégoire, Elizabeth A. Ainsbury, Leonardo Barrios, C. Bassinet, P. Fattibene , et al. · 2016

The methodology used to harmonize all dosimetry practice within the network RENEB was highly successful. The network is operational to manage a mass casualty radiation accident for immediate dose assessment.

Analysis of α-particle-induced chromosomal aberrations by chemically-induced PCC. Elaboration of dose-effect curves Open

Roser Puig, Mònica Pujol-Canadell, Leonardo Barrios, M.R. Caballı́n, Joan Francesc Barquinero · 2016

In a similar way to high-dose exposures to low-LET radiations, cells show difficulties reaching mitosis after high-LET radiation exposure. For this reason, techniques have been proposed that are able to analyze chromosome aberrations in in…

Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans – joint RENEB and EURADOS inter-laboratory comparisons Open

Elizabeth A. Ainsbury, Christophe Badie, Stephen Barnard, Grainne Manning, Jayne Moquet , et al. · 2016

Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.

Differences in DNA Repair Capacity, Cell Death and Transcriptional Response after Irradiation between a Radiosensitive and a Radioresistant Cell Line Open

Mireia Borràs-Fresneda, Joan Francesc Barquinero, Maria Gomolka, Sabine Hornhardt, Ute Rößler , et al. · 2016

Effect of Surface Modifications of Ti40Zr10Cu38Pd12 Bulk Metallic Glass and Ti-6Al-4V Alloy on Human Osteoblasts In Vitro Biocompatibility Open

Andreu Blanquer, Anna Hynowska, Carme Nogués, Elena Ibáñez, Jordi Sort , et al. · 2016

The use of biocompatible materials, including bulk metallic glasses (BMGs), for tissue regeneration and transplantation is increasing. The good mechanical and corrosion properties of Ti40Zr10Cu38Pd12 BMG and its previously described biocom…

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