Leonardo Betancurt-Anzola
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View article: The A, B, C, D’s of replicative DNA polymerase fidelity: utilizing high-throughput single-molecule sequencing to understand the molecular basis for DNA polymerase accuracy
The A, B, C, D’s of replicative DNA polymerase fidelity: utilizing high-throughput single-molecule sequencing to understand the molecular basis for DNA polymerase accuracy Open
DNA polymerases (DNAPs) are indispensable enzymes that play central roles in biology, by replicating and repairing genetic material, as well as in biotechnology, by fueling such innovations as polymerase chain reaction (PCR), cloning, and …
View article: The A, B, C, D’s of replicative DNA polymerase fidelity: utilizing high-throughput single-molecule sequencing to understand the molecular basis for DNA polymerase accuracy
The A, B, C, D’s of replicative DNA polymerase fidelity: utilizing high-throughput single-molecule sequencing to understand the molecular basis for DNA polymerase accuracy Open
DNA polymerases (DNAPs) are indispensable enzymes that play central roles in biology, by replicating and repairing genetic material, as well as in biotechnology, by fueling such innovations as polymerase chain reaction (PCR), cloning, and …
View article: Template-Independent Enzymatic RNA Synthesis
Template-Independent Enzymatic RNA Synthesis Open
A route to prepare ribonucleoside triphosphates featuring a 3’-aminoxy (3’-O-NH 2 ) removable blocking group is reported here. We then show that versions of two DNA polymerases, human DNA polymerase theta (Polθ) and mimiviral PrimPol, acce…
View article: Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases
Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases Open
Replicative DNA polymerases duplicate entire genomes at high fidelity. This feature is shared among the three domains of life and is facilitated by their dual polymerase and exonuclease activities. Family D replicative DNA polymerases (Pol…
View article: Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases
Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases Open
Replicative DNA polymerases duplicate entire genomes at high fidelity. This feature is shared among the three domains of life and is facilitated by their dual polymerase and exonuclease activities. Family D replicative DNA polymerases (Pol…
View article: Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases
Molecular basis for proofreading by the unique exonuclease domain of Family-D DNA polymerases Open
Replicative DNA polymerases duplicate entire genomes at high fidelity. This feature is shared among the three domains of life and is facilitated by their dual polymerase and exonuclease activities. Family D replicative DNA polymerases (Pol…