Leonardo Cristinziano
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View article: Effects of Advanced Glycation End Products (AGEs) on Human Lung Macrophages: Implications for Pulmonary Inflammation
Effects of Advanced Glycation End Products (AGEs) on Human Lung Macrophages: Implications for Pulmonary Inflammation Open
AGE accumulation promotes a pro-inflammatory phenotype in HLMs, potentially contributing to lung injury and respiratory dysfunction in AGEs-related diseases through the release of pro-inflammatory mediators. These findings highlight HLMs a…
View article: Histamine as a mediator of cross-talk between human lung mast cells and macrophages
Histamine as a mediator of cross-talk between human lung mast cells and macrophages Open
View article: Differential activation of monocytes and PMNs in orofacial granulomatosis patients induced by bacterial and non-bacterial stimuli
Differential activation of monocytes and PMNs in orofacial granulomatosis patients induced by bacterial and non-bacterial stimuli Open
Introduction Orofacial Granulomatosis (OFG) is a rare chronic inflammatory disorder characterized by persistent or recurrent swelling of the lips and oral mucosa, often accompanied by granulomatous inflammation in the orofacial region with…
View article: Neutrophil exhaustion and impaired functionality in psoriatic arthritis patients
Neutrophil exhaustion and impaired functionality in psoriatic arthritis patients Open
Background Neutrophils (polymorphonuclear leukocytes, PMNs) are the most abundant subtype of white blood cells and are among the main actors in the inflammatory response. Psoriatic arthritis (PsA) is a chronic inflammatory disease affectin…
View article: The JAK1/JAK2 inhibitor ruxolitinib inhibits mediator release from human basophils and mast cells
The JAK1/JAK2 inhibitor ruxolitinib inhibits mediator release from human basophils and mast cells Open
Introduction The Janus kinase (JAK) family includes four cytoplasmic tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) constitutively bound to several cytokine receptors. JAKs phosphorylate downstream signal transducers and activators of trans…
View article: Innate Immune Cells in Melanoma: Implications for Immunotherapy
Innate Immune Cells in Melanoma: Implications for Immunotherapy Open
The innate immune system, composed of neutrophils, basophils, eosinophils, myeloid-derived suppressor cells (MDSCs), macrophages, dendritic cells (DCs), mast cells (MCs), and innate lymphoid cells (ILCs), is the first line of defense. Grow…
View article: The broad spectrum of cardiotoxicities from immunotherapies
The broad spectrum of cardiotoxicities from immunotherapies Open
OPINION article Front. Cardiovasc. Med., 15 September 2023Sec. Cardio-Oncology Volume 10 - 2023 | https://doi.org/10.3389/fcvm.2023.1259620
View article: Neutrophil extracellular traps and neutrophil-related mediators in human thyroid cancer
Neutrophil extracellular traps and neutrophil-related mediators in human thyroid cancer Open
Background Polymorphonuclear neutrophils (PMNs) are the main effector cells in inflammatory responses and play multiple roles in thyroid cancer (TC). PMNs contain and release a plethora of mediators, including granular enzymes [e.g., myelo…
View article: Melanoma-derived soluble mediators modulate neutrophil biological properties and the release of neutrophil extracellular traps
Melanoma-derived soluble mediators modulate neutrophil biological properties and the release of neutrophil extracellular traps Open
View article: Melanoma-derived soluble mediators modulate neutrophil plasticity and the release of Neutrophil Extracellular Traps
Melanoma-derived soluble mediators modulate neutrophil plasticity and the release of Neutrophil Extracellular Traps Open
Background: polymorphonuclear neutrophils (PMNs) are main effector cells in the inflammatory responses. The significance of PMN infiltration in tumor microenvironment remains to be clarified. Metastatic melanoma is the most lethal type of …
View article: Melanoma-derived soluble mediators modulate neutrophil plasticity and the release of Neutrophil Extracellular Traps
Melanoma-derived soluble mediators modulate neutrophil plasticity and the release of Neutrophil Extracellular Traps Open
Background: polymorphonuclear neutrophils (PMNs) are main effector cells in the inflammatory responses. The significance of PMN infiltration in tumor microenvironment remains to be clarified. Metastatic melanoma is the most lethal type of …
View article: SARS-CoV-2 Spike Protein Activates Human Lung Macrophages
SARS-CoV-2 Spike Protein Activates Human Lung Macrophages Open
COVID-19 is a viral disease caused by SARS-CoV-2. This disease is characterized primarily, but not exclusively, by respiratory tract inflammation. SARS-CoV-2 infection relies on the binding of spike protein to ACE2 on the host cells. The v…
View article: PD-L1+ neutrophils as novel biomarkers for stage IV melanoma patients treated with nivolumab
PD-L1+ neutrophils as novel biomarkers for stage IV melanoma patients treated with nivolumab Open
Melanoma displays a rising incidence, and the mortality associated with metastatic form remains high. Monoclonal antibodies that block programmed death (PD-1) and PD Ligand 1 (PD-L1) network have revolutionized the history of metastatic di…
View article: Size-based effects of anthropogenic ultrafine particles on activation of human lung macrophages
Size-based effects of anthropogenic ultrafine particles on activation of human lung macrophages Open
View article: Neutrophil Extracellular Traps, Angiogenesis and Cancer
Neutrophil Extracellular Traps, Angiogenesis and Cancer Open
Human neutrophils, the most abundant circulating leukocytes, are fundamental components of the host response against different pathogens. Until a few years ago, neutrophils received limited attention in cancer immunology. Recently, it was …
View article: Neutrophil extracellular traps and neutrophil-derived mediators as possible biomarkers in bronchial asthma
Neutrophil extracellular traps and neutrophil-derived mediators as possible biomarkers in bronchial asthma Open
Neutrophils (PMNs) contain and release a powerful arsenal of mediators, including several granular enzymes, reactive oxygen species (ROS) and neutrophil extracellular traps (NETs). Although airway neutrophilia is associated with severity, …
View article: Roles of Immune Cells in Hereditary Angioedema
Roles of Immune Cells in Hereditary Angioedema Open
Hereditary angioedema (HAE) is a rare genetic disease, characterized by recurrent and unexpected potentially life-threatening mucosal swelling. HAE may be further classified into HAE with C1‐inhibitor deficiency (C1‐INH‐HAE) and HAE with n…
View article: Vascular endothelial growth factors and angiopoietins as new players in mastocytosis
Vascular endothelial growth factors and angiopoietins as new players in mastocytosis Open
Mastocytosis is a disorder characterized by the abnormal proliferation and/or accumulation of mast cells in different organs. More than 90% of patients with systemic mastocytosis have a gain-of-function mutation in codon 816 of the KIT rec…
View article: Vascular Endothelial Growth Factors and Angiopoietins As New Players in Mastocytosis
Vascular Endothelial Growth Factors and Angiopoietins As New Players in Mastocytosis Open
Mastocytosis is a disorder characterized by the abnormal proliferation and/or accumulation of mast cells in different organs. More than 90% of patients with systemic mastocytosis have a gain-of-function mutation in codon 816 of the KIT rec…
View article: IL-33 and Superantigenic Activation of Human Lung Mast Cells Induce the Release of Angiogenic and Lymphangiogenic Factors
IL-33 and Superantigenic Activation of Human Lung Mast Cells Induce the Release of Angiogenic and Lymphangiogenic Factors Open
Human lung mast cells (HLMCs) express the high-affinity receptor FcεRI for IgE and are strategically located in different compartments of human lung, where they play a role in several inflammatory disorders and cancer. Immunoglobulin super…
View article: Macrophage-polarizing stimuli differentially modulate the inflammatory profile induced by the secreted phospholipase A2 group IA in human lung macrophages
Macrophage-polarizing stimuli differentially modulate the inflammatory profile induced by the secreted phospholipase A2 group IA in human lung macrophages Open
View article: VEGF-A in Cardiomyocytes and Heart Diseases
VEGF-A in Cardiomyocytes and Heart Diseases Open
The vascular endothelial growth factor (VEGF), a homodimeric vasoactive glycoprotein, is the key mediator of angiogenesis. Angiogenesis, the formation of new blood vessels, is responsible for a wide variety of physio/pathological processes…
View article: Hereditary angioedema attack: what happens to vasoactive mediators?
Hereditary angioedema attack: what happens to vasoactive mediators? Open
Hereditary angioedema is a disabling, life-threatening condition caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein (C1-INH-HAE) leading to bradykinin accumulation and recurrent episodes of edema attack. Vas…