Leonardo Moura Midon
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View article: Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic <i>Leptospira interrogans</i> infection
Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic <i>Leptospira interrogans</i> infection Open
Leptospirosis is a neglected disease caused by pathogenic Leptospira spp., affecting an estimated 1 million people annually and resulting in approximately 60,000 deaths. The disease can lead to hepatic, renal, and pulmonary dysfunctions an…
View article: TLR4 competence and mouse models of sublethal leptospirosis
TLR4 competence and mouse models of sublethal leptospirosis Open
Mice are slowly being accepted as alternative models for investigation of leptospiral infection. The strain often used to analyze sublethal disease (C3H/HeJ) expresses a hyporesponsive tlr4 gene in its cells and thus the model is deemed im…
View article: Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic <i>Leptospira interrogans</i> Infection
Complement C3 Deficiency Enhances Renal Leptospiral Load and Inflammation While Impairing T Cell Differentiation During Chronic <i>Leptospira interrogans</i> Infection Open
Leptospirosis is a neglected zoonotic disease caused by pathogenic Leptospira spp., affecting an estimated of one million people annually and resulting in approximately 60,000 fatalities. The disease can lead to hepatic, renal, and pulmona…
View article: TLR4 competence and mouse models of leptospirosis
TLR4 competence and mouse models of leptospirosis Open
Mice are slowly being accepted as alternative models for investigation of leptospiral infection. The strain most used to analyse sublethal disease (C3H-HeJ) expresses a tlr4 gene in its immune cells that is hyporesponsive to leptospiral LP…