Leonardo Tozzi
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View article: Brain morphology mediators of the link between childhood trauma and bipolar disorder: a large-scale international analysis
Brain morphology mediators of the link between childhood trauma and bipolar disorder: a large-scale international analysis Open
Childhood trauma is a risk factor for bipolar disorder, but the biological mechanisms of this association remain incompletely defined. Gray matter differences observed after trauma exposure overlap with those reported in bipolar disorder, …
View article: Validation of a New AI Seizure Detection Algorithm for Pre-term Neonates, Term Neonates and Infants
Validation of a New AI Seizure Detection Algorithm for Pre-term Neonates, Term Neonates and Infants Open
Seizures are frequent in the first year of life and they are associated with increased risk of long-term neurological disability. Accurate diagnosis of seizures in neonates and infants requires continuous electroencephalogram (EEG) monitor…
View article: A stratified precision medicine trial targeting α2A-adrenergic receptor agonism as a treatment for the cognitive biotype of depression
A stratified precision medicine trial targeting α2A-adrenergic receptor agonism as a treatment for the cognitive biotype of depression Open
View article: A Stratified Precision Medicine Trial Targeting Selective Mechanisms of Alpha 2A Agonism as a Treatment for the Cognitive Biotype of Depression: The BIomarker Guided (BIG) Study for Depression
A Stratified Precision Medicine Trial Targeting Selective Mechanisms of Alpha 2A Agonism as a Treatment for the Cognitive Biotype of Depression: The BIomarker Guided (BIG) Study for Depression Open
View article: Adaptive cognitive control circuit changes associated with problem-solving ability and depression symptom outcomes over 24 months
Adaptive cognitive control circuit changes associated with problem-solving ability and depression symptom outcomes over 24 months Open
Mechanistically targeted behavioral interventions are a much-needed strategy for improving outcomes in depression, especially for vulnerable populations with comorbidities such as obesity. Such interventions may change behavior and outcome…
View article: Brain Circuit–Derived Biotypes for Treatment Selection in Mood Disorders: A Critical Review and Illustration of a Functional Neuroimaging Tool for Clinical Translation
Brain Circuit–Derived Biotypes for Treatment Selection in Mood Disorders: A Critical Review and Illustration of a Functional Neuroimaging Tool for Clinical Translation Open
View article: Specific alterations of resting‐state functional connectivity in the triple network related to comorbid anxiety in major depressive disorder
Specific alterations of resting‐state functional connectivity in the triple network related to comorbid anxiety in major depressive disorder Open
The brain's default mode network (DMN) and the executive control network (ECN) switch engagement are influenced by the ventral attention network (VAN). Alterations in resting‐state functional connectivity (RSFC) within this so‐called tripl…
View article: In vivo structural analyses of amygdala subregions in relation to stressful life events: A systematic review
In vivo structural analyses of amygdala subregions in relation to stressful life events: A systematic review Open
Exposure to stress, particularly during childhood, has been linked to chronic medical conditions, including mental disorders. In recent years, advancements in modern segmentation techniques for magnetic resonance imaging (MRI) have allowed…
View article: Specific alterations of resting-state functional connectivity in the triple network related to comorbid anxiety in major depressive disorder
Specific alterations of resting-state functional connectivity in the triple network related to comorbid anxiety in major depressive disorder Open
The brain‘s default mode network (DMN) and the executive control network (ECN) switch engagement influenced by the ventral attention network (VAN). Alterations in resting-state functional connectivity (RSFC) within this so-called triple ne…
View article: Co-existence of negative and positive associations between cognition and intergenerational psychiatric symptoms reveal necessity of socioeconomic and clinical enrichment
Co-existence of negative and positive associations between cognition and intergenerational psychiatric symptoms reveal necessity of socioeconomic and clinical enrichment Open
Background Mental illnesses are a leading cause of disability globally. Across 17 psychiatric disorders, functional disability is often in part caused by cognitive impairments. However, cognitive heterogeneity in mental health is poorly un…
View article: A Cognitive Biotype of Depression Linking Symptoms, Behavior Measures, Neural Circuits, and Differential Treatment Outcomes
A Cognitive Biotype of Depression Linking Symptoms, Behavior Measures, Neural Circuits, and Differential Treatment Outcomes Open
Importance Cognitive deficits in depression have been associated with poor functional capacity, frontal neural circuit dysfunction, and worse response to conventional antidepressants. However, it is not known whether these impairments comb…
View article: Machine Learning Prediction of Estimated Risk for Bipolar Disorders Using Hippocampal Subfield and Amygdala Nuclei Volumes
Machine Learning Prediction of Estimated Risk for Bipolar Disorders Using Hippocampal Subfield and Amygdala Nuclei Volumes Open
The pathophysiology of bipolar disorder (BD) remains mostly unclear. Yet, a valid biomarker is necessary to improve early detection of this serious disorder. Patients with manifest BD display reduced volumes of the hippocampal subfields an…
View article: Neurocognitive Dysfunction in Children and Adolescents with Mental Illness
Neurocognitive Dysfunction in Children and Adolescents with Mental Illness Open
Introduction Robust evidence from adult samples indicates that neurocognitive dysfunction is a hallmark of many mental illnesses, contributing to the loss of daily function and quality of life that these illnesses cause. However, it is sti…
View article: Treatment efficacy and effectiveness in adults with major depressive disorder and childhood trauma history: a systematic review and meta-analysis
Treatment efficacy and effectiveness in adults with major depressive disorder and childhood trauma history: a systematic review and meta-analysis Open
View article: Convergence, preliminary findings and future directions across the four human connectome projects investigating mood and anxiety disorders
Convergence, preliminary findings and future directions across the four human connectome projects investigating mood and anxiety disorders Open
In this paper we provide an overview of the rationale, methods, and preliminary results of the four Connectome Studies Related to Human Disease investigating mood and anxiety disorders. The first study, "Dimensional connectomics of anxious…
View article: Canonical correlation analysis in high dimensions with structured regularization
Canonical correlation analysis in high dimensions with structured regularization Open
Canonical correlation analysis (CCA) is a technique for measuring the association between two multivariate data matrices. A regularized modification of canonical correlation analysis (RCCA) which imposes an [Formula: see text] penalty on t…
View article: The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress
The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress Open
Yann Quidé,1,2 Leonardo Tozzi,3 Mark Corcoran,4 Dara M Cannon,5 Maria R Dauvermann6,7 1School of Psychiatry, University of New South Wales (UNSW), Sydney, NSW, Australia; 2Neuroscience Research Australia, Randwick, NSW, Australia; 3Departm…
View article: <p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>
The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress Open
Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on retrospective and cross-sectional studies in adults with BD. The first…
View article: Canonical Correlation Analysis in high dimensions with structured\n regularization
Canonical Correlation Analysis in high dimensions with structured\n regularization Open
Canonical correlation analysis (CCA) is a technique for measuring the\nassociation between two multivariate data matrices. A regularized modification\nof canonical correlation analysis (RCCA) which imposes an $\\ell_2$ penalty on\nthe CCA …
View article: Brain network connectivity in major depression: extending findings from a large public data set by meta-analysis across sites
Brain network connectivity in major depression: extending findings from a large public data set by meta-analysis across sites Open
A bstract In this short communication, we test whether patients with major depression and healthy individuals have different functional connectivity within established brain networks. To this end, we leverage a very large multi-site data s…
View article: Constrained Bayesian ICA for Brain Connectome Inference
Constrained Bayesian ICA for Brain Connectome Inference Open
Brain connectomics is a developing field in neurosciences which strives to understand cognitive processes and psychiatric diseases through the analysis of interactions between brain regions. However, in the high-dimensional, low-sample, an…
View article: Short-term test-retest reliability of the human intrinsic functional connectome
Short-term test-retest reliability of the human intrinsic functional connectome Open
Functional connectivity is frequently used to quantify the complex synchronous distributed fluctuations in neuronal activity derived from functional Magnetic Resonance Imaging and to generate network representations of human brain function…
View article: White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group Open
View article: Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort
Interactive impact of childhood maltreatment, depression, and age on cortical brain structure: mega-analytic findings from a large multi-site cohort Open
Background Childhood maltreatment (CM) plays an important role in the development of major depressive disorder (MDD). The aim of this study was to examine whether CM severity and type are associated with MDD-related brain alterations, and …
View article: Neurobiological correlates of violence perception in martial artists
Neurobiological correlates of violence perception in martial artists Open
Objectives The direct exertion as well as the visual perception of violence can have a hedonistic effect and elicit positive arousal in predisposed individuals. This appetitive aspect of aggression in healthy subjects has been neglected in…
View article: 10Kin1day: A bottom-up neuroimaging initiative
10Kin1day: A bottom-up neuroimaging initiative Open
We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe …
View article: Neuroimaging in depression
Neuroimaging in depression Open
Neuroimaging techniques are important clinically, to exclude organic disorders as origins of depression. For research, they provide insight into brain structure, function and network organization, indicating the relevance of different brai…
View article: The role of FKBP5 genetics and epigenetics in mediating the effects of early life adversity on emotional processing brain regions in major depressive disorder
The role of FKBP5 genetics and epigenetics in mediating the effects of early life adversity on emotional processing brain regions in major depressive disorder Open
Major depressive disorder (MDD) is the most widespread psychiatric illness and is characterized by loss of pleasure, depressed mood, sleep disturbances and anxiety. Recently, an inflammatory theory of MDD has emerged, which postulates that…
View article: Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression
Epigenetic Changes of FKBP5 as a Link Connecting Genetic and Environmental Risk Factors with Structural and Functional Brain Changes in Major Depression Open
View article: Diurnal Hypothalamic-Pituitary-Adrenal Axis Measures and Inflammatory Marker Correlates in Major Depressive Disorder
Diurnal Hypothalamic-Pituitary-Adrenal Axis Measures and Inflammatory Marker Correlates in Major Depressive Disorder Open
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and inflammatory systems is a consistent finding in patients with Major Depressive Disorder (MDD). Cortisol is often assessed by measurement of the cortisol awakening response …