Silvânia Maria Mendes Vasconcelos
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View article: DESAFIOS DA INTEGRAÇÃO TECNOLÓGICA NO ENSINO BÁSICO
DESAFIOS DA INTEGRAÇÃO TECNOLÓGICA NO ENSINO BÁSICO Open
O presente estudo abordou a integração de tecnologias baseadas em computador à sala de aula da educação básica, com foco nos desafios estruturais e nas oportunidades pedagógicas. Partiu-se do problema: quais são os limites estruturais e as…
View article: Targeting the Dectin-1 Receptor in Neuroinflammation: Therapeutic Implications for Neuropsychiatric Disorders
Targeting the Dectin-1 Receptor in Neuroinflammation: Therapeutic Implications for Neuropsychiatric Disorders Open
Exploring the role of the pattern recognition receptor Dectin-1 in neurological diseases emerges as an important target for understanding the biochemical and physiological dynamics of neuropathologies. From this perspective, Dectin-1, prot…
View article: INTEGRAÇÃO E MEDIAÇÃO NO EAD: PERSPECTIVAS DE ESTUDANTES, DOCENTES E TUTORES
INTEGRAÇÃO E MEDIAÇÃO NO EAD: PERSPECTIVAS DE ESTUDANTES, DOCENTES E TUTORES Open
Este estudo investigou as práticas de mediação pedagógica na Educação a Distância (EAD), com foco na integração de metodologias ativas e tecnologias digitais. O problema central da pesquisa foi compreender como a mediação pedagógica, aliad…
View article: IMAGENS QUE ENSINAM: A EXPRESSIVIDADE VISUAL COMO ESTRATÉGIA DE ENSINO
IMAGENS QUE ENSINAM: A EXPRESSIVIDADE VISUAL COMO ESTRATÉGIA DE ENSINO Open
Esta pesquisa teve como objetivo analisar o impacto do uso de recursos multimídias, especialmente imagens e vídeos, na promoção de uma aprendizagem significativa e crítica, considerando a expressividade visual como uma estratégia pedagógic…
View article: Polysaccharide-rich extract of Genipa americana leaves protects seizures and oxidative stress in the mice model of pentylenetetrazole-induced epilepsy
Polysaccharide-rich extract of Genipa americana leaves protects seizures and oxidative stress in the mice model of pentylenetetrazole-induced epilepsy Open
Plant polysaccharides have biological activities in the brain and those obtained from Genipa americana leaves present antioxidant and anticonvulsant effects in the mice model of pentylenetetrazole (PTZ)-induced acute seizures. This study a…
View article: Decrease in cognitive performance and increase of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with higher doses of antipsychotics in women with schizophrenia: a cross-sectional study
Decrease in cognitive performance and increase of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with higher doses of antipsychotics in women with schizophrenia: a cross-sectional study Open
Background We explored the relationship between symptoms, cognitive performance, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) (three markers of inflammation), and antipsyc…
View article: Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells
Epiisopiloturine, an Alkaloid from Pilocarpus microphyllus, Attenuates LPS-Induced Neuroinflammation by Interfering in the TLR4/NF-κB-MAPK Signaling Pathway in Microglial Cells Open
Neuroinflammation is present in the pathophysiological mechanisms of several diseases that affect the central nervous system (CNS). Microglia have a prominent role in initiating and sustaining the inflammatory process. Epiisopiloturine (EP…
View article: Oxidative stress and inflammatory process in borderline personality disorder (BPD): a narrative review
Oxidative stress and inflammatory process in borderline personality disorder (BPD): a narrative review Open
Borderline personality disorder (BPD) is a severe psychiatric condition that affects up to 2.7% of the population and is highly linked to functional impairment and suicide. Despite its severity, there is a lack of knowledge about its patho…
View article: Sex and the estrous-cycle phase influence the expression of G protein-coupled estrogen receptor 1 (GPER) in schizophrenia: translational evidence for a new target.
Sex and the estrous-cycle phase influence the expression of G protein-coupled estrogen receptor 1 (GPER) in schizophrenia: translational evidence for a new target. Open
Schizophrenia is a mental disorder with sex bias in disease onset and symptom severity. Recently, it was observed that females present more severe symptoms in the perimenstrual phase of the menstrual cycle. The administration of estrogen a…
View article: Prevalência e Fatores Associados a Transtornos Mentais Entre Universitários da Área da Saúde: Revisão de Literatura
Prevalência e Fatores Associados a Transtornos Mentais Entre Universitários da Área da Saúde: Revisão de Literatura Open
Objetivos: Analisar as principais produções da literatura científica brasileira sobre a prevalência e os fatores associados aos transtornos mentais entre estudantes universitários da área da saúde. Fonte de dados: Foi realizada uma revisão…
View article: Anxiolytic Effect of Carvedilol in Chronic Unpredictable Stress Model
Anxiolytic Effect of Carvedilol in Chronic Unpredictable Stress Model Open
Anxiety disorders are the most prevalent psychiatric disorders being also a comorbid state of other diseases. We aimed to evaluate the anxiolytic‐like effects of carvedilol (CVD), a drug used to treat high blood pressure and heart failure …
View article: Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment?
Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment? Open
The use of bladder antimuscarinics is very common in the elderly. However, recent population-based studies that assessed the use of anticholinergics or bladder antimuscarinics showed an increased risk of dementia when these drugs were used…
View article: Involvement of Anti-Inflammatory, Antioxidant, and BDNF Up-Regulating Properties in the Antipsychotic-Like Effect of the Essential Oil of Alpinia Zerumbet in Mice: A Comparative Study With Olanzapine
Involvement of Anti-Inflammatory, Antioxidant, and BDNF Up-Regulating Properties in the Antipsychotic-Like Effect of the Essential Oil of Alpinia Zerumbet in Mice: A Comparative Study With Olanzapine Open
The current drug therapy for schizophrenia effectively treats acute psychosis and its recurrence; however, this mental disorder’s cognitive and negative symptoms are still poorly controlled. Antipsychotics present important side effects, s…
View article: Rapid and long-lasting antidepressant-like effects of ketamine and their relationship with the expression of brain enzymes, BDNF, and astrocytes
Rapid and long-lasting antidepressant-like effects of ketamine and their relationship with the expression of brain enzymes, BDNF, and astrocytes Open
Ketamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms f…
View article: Rapid and long-lasting antidepressant-like effects of ketamine and their relationship with the expression of brain enzymes, BDNF, and astrocytes
Rapid and long-lasting antidepressant-like effects of ketamine and their relationship with the expression of brain enzymes, BDNF, and astrocytes Open
Ketamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms f…
View article: The Alpha-Lipoic Acid Improves Survival and Prevents Irinotecan-Induced Inflammation and Intestinal Dysmotility in Mice
The Alpha-Lipoic Acid Improves Survival and Prevents Irinotecan-Induced Inflammation and Intestinal Dysmotility in Mice Open
Irinotecan, an anticancer drug, induces diarrhea and intestinal inflammation, resulting in an increase in the cost of care and in treatment delays. In this study, we investigated whether alpha-lipoic acid (α-LA) could improve irinotecan-me…
View article: EFEITOS DO GÊNERO CITRUS NO SISTEMA NERVOSO CENTRAL: UMA REVISÃO DE LITERATURA / CITRUS GENDER EFFECTS ON THE CENTRAL NERVOUS SYSTEM: A LITERATURE REVIEW
EFEITOS DO GÊNERO CITRUS NO SISTEMA NERVOSO CENTRAL: UMA REVISÃO DE LITERATURA / CITRUS GENDER EFFECTS ON THE CENTRAL NERVOUS SYSTEM: A LITERATURE REVIEW Open
View article: High Exploratory Phenotype Rats Exposed to Environmental Stressors Present Memory Deficits Accompanied by Immune-Inflammatory/Oxidative Alterations: Relevance to the Relationship Between Temperament and Mood Disorders
High Exploratory Phenotype Rats Exposed to Environmental Stressors Present Memory Deficits Accompanied by Immune-Inflammatory/Oxidative Alterations: Relevance to the Relationship Between Temperament and Mood Disorders Open
Low-exploratory (LE) and high-exploratory (HE) rodents mimic human depressive and hyperthymic temperaments, respectively. Mood disorders (MD) may be developed by the exposure of these temperaments to environmental stress (ES). Psychiatric …
View article: Evidence for Host Epigenetic Signatures Arising From Arbovirus Infections: A Systematic Review
Evidence for Host Epigenetic Signatures Arising From Arbovirus Infections: A Systematic Review Open
Background: Arbovirus infections have steadily become a major pandemic threat. This study aimed at investigating the existence of host epigenetic markers arising from the principal arboviruses infections impacting on human health. W…
View article: Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review
Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review Open
Cocos nucifera (L.) (Arecaceae) is commonly called the “coconut tree” and is the most naturally widespread fruit plant on Earth. Throughout history, humans have used medicinal plants therapeutically, and minerals, plants, and animals have …
View article: Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system
Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system Open
Hoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. Recently, it has been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The…
View article: Ivabradine possesses anticonvulsant and neuroprotective action in mice
Ivabradine possesses anticonvulsant and neuroprotective action in mice Open
View article: Prevention of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: Involvement of brain antioxidant and BDNF upregulating properties
Prevention of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: Involvement of brain antioxidant and BDNF upregulating properties Open
View article: Efeito da rutina em modelo de depressão crônico induzido por corticosterona em camundongos
Efeito da rutina em modelo de depressão crônico induzido por corticosterona em camundongos Open
Introdução: a depressão é uma doença altamente prevalente na população mundial e apesar de não ter sua causa estabelecida, algumas teorias tentam esclarecer sua etiologia. A rutina é um flavonoide pertencente à classe dos flavonóis, que te…
View article: IDO chronic immune activation and tryptophan metabolic pathway: A potential pathophysiological link between depression and obesity
IDO chronic immune activation and tryptophan metabolic pathway: A potential pathophysiological link between depression and obesity Open
Obesity and depression are among the most pressing health problems in the contemporary world. Obesity and depression share a bidirectional relationship, whereby each condition increases the risk of the other. By inference, shared pathways …
View article: Impact of the Chronic Omega‐3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6‐Hydroxydopamine in Rats
Impact of the Chronic Omega‐3 Fatty Acids Supplementation in Hemiparkinsonism Model Induced by 6‐Hydroxydopamine in Rats Open
Parkinson's disease ( PD ) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra. The neuronal degeneration may result from the convergence of a number of different pathogenic factors, including apo…
View article: Pharmacognostical Analysis and Protective Effect of Standardized Extract and Rizonic Acid from <i>Erythrina velutina</i> against 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells.
Pharmacognostical Analysis and Protective Effect of Standardized Extract and Rizonic Acid from <i>Erythrina velutina</i> against 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells. Open
The powder of Erythrina velutina was classified as moderately coarse and several quality-control parameters were determined.Ethanolic extract from E. velutina (EEEV) produced by percolation gave the highest phenol content whe…
View article: Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review
Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review Open
Cocos nucifera (L.) (Arecaceae) is commonly called the "coconut tree" and is the most naturally widespread fruit plant on Earth. Throughout history, humans have used medicinal plants therapeutically, and minerals, plants, and animals have …
View article: The psychophysiology of pain: a literature review
The psychophysiology of pain: a literature review Open
The International Association for the Study of Pain defines pain as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage”. The sensory aspect of pain is asso…