Leonid Churilov
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View article: A systematic review of early neuroimaging and neurophysiological biomarkers for post-stroke mobility prognostication
A systematic review of early neuroimaging and neurophysiological biomarkers for post-stroke mobility prognostication Open
Background Accurate prognostication of mobility outcomes is essential to guide rehabilitation and manage patient expectations. The prognostic utility of neuroimaging and neurophysiological biomarkers remains uncertain when measured early p…
View article: T-cell immune profile changes predict durable response to nivolumab-rituximab in treatment-naïve FL
T-cell immune profile changes predict durable response to nivolumab-rituximab in treatment-naïve FL Open
View article: Reimagining acute diabetes care: Insights from the Victorian Virtual Emergency Department
Reimagining acute diabetes care: Insights from the Victorian Virtual Emergency Department Open
ObjectiveNew approaches to diabetes care are needed to better identify and manage diabetes emergencies outside of hospitals.Research Design and MethodsA retrospective, descriptive analysis was conducted using data from the Victorian Virtua…
View article: Safety and Efficacy of Perispinal Etanercept for Chronic Stroke
Safety and Efficacy of Perispinal Etanercept for Chronic Stroke Open
This study provides Class I evidence that in patients with imaging-confirmed ischemic or hemorrhagic stroke, perispinal etanercept (25 mg) injection does not improve the patients' quality of life 28 days after injection.
View article: General Practitioner Coordinated Multidisciplinary Care Improves Long-Term Survival following Stroke with Variation by Impairment
General Practitioner Coordinated Multidisciplinary Care Improves Long-Term Survival following Stroke with Variation by Impairment Open
Background: Australian Medicare funded policies to support General Practtitioners (GPs) to coordinate multidisciplinary care (MDC) with other healthcare providers have potential to benefit survivors of stroke/transient ischaemic attack (TI…
View article: Ketosis and ketoacidosis in hospitalized patients receiving <scp>SGLT2</scp> inhibitor therapy
Ketosis and ketoacidosis in hospitalized patients receiving <span>SGLT2</span> inhibitor therapy Open
Aims The use and safety of sodium‐glucose co‐transporter 2 inhibitors (SGLT2i) in hospital are controversial due to the risk of ketoacidosis. We aimed to describe rates of ketosis, ketoacidosis, and acidosis in patients with type 2 diabete…
View article: Design Ideas for Inpatient Stroke Rehabilitation Facilities: Living Lab Findings
Design Ideas for Inpatient Stroke Rehabilitation Facilities: Living Lab Findings Open
Objectives To provide actionable, co-designed ideas for how to optimize the built environment and service of inpatient stroke rehabilitation facilities. Background Input from diverse stakeholders is needed to ensure that stroke rehabilitat…
View article: Ultra-early computed tomography markers of haematoma expansion: Potential trial targets?
Ultra-early computed tomography markers of haematoma expansion: Potential trial targets? Open
Introduction: The predictive value of CT markers of intracerebral haemorrhage (ICH) expansion is time-dependent, but data in the ultra-early period (<2 h from onset) are limited. We aimed to describe the frequency of these CT markers, thei…
View article: The prevalence of apathy in Lewy body dementia: A systematic review and meta‐analysis
The prevalence of apathy in Lewy body dementia: A systematic review and meta‐analysis Open
INTRODUCTION Apathy is an important syndrome in Lewy body dementia (LBD), although reported prevalences vary. We aimed to estimate the prevalence of apathy in LBD through systematic review and meta‐analysis. METHODS Five databases were sea…
View article: T-cell dysregulation informs radiotherapy-immunotherapy response in B-cell lymphoma: results from a phase 1 trial
T-cell dysregulation informs radiotherapy-immunotherapy response in B-cell lymphoma: results from a phase 1 trial Open
Diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) are highly radiosensitive with immune-driven abscopal responses reported. Programmed cell death 1/programmed cell death ligand 1 (PD-L1) inhibitors are relatively ineffecti…
View article: Transforming Community‐Based Rehabilitation Services: A National Redesign Using Experience‐Based Co‐Design
Transforming Community‐Based Rehabilitation Services: A National Redesign Using Experience‐Based Co‐Design Open
Background To understand the experiences of clients, caregivers and staff in community day rehabilitation centres (DRCs) and identify areas for improvement in service processes and the clinical care of stroke, frailty and hip fracture, a n…
View article: 296 | LIMITED STAGE DIFFUSE LARGE B CELL LYMPHOMA IN THE MODERN ERA: REAL‐WORLD OUTCOMES IN AN INTERNATIONAL STUDY OF OVER ONE THOUSAND PATIENTS
296 | LIMITED STAGE DIFFUSE LARGE B CELL LYMPHOMA IN THE MODERN ERA: REAL‐WORLD OUTCOMES IN AN INTERNATIONAL STUDY OF OVER ONE THOUSAND PATIENTS Open
View article: Robotic Stroke Thrombectomy: A Feasibility and Efficacy Study in Flow Models
Robotic Stroke Thrombectomy: A Feasibility and Efficacy Study in Flow Models Open
View article: Optimizing CTP in Posterior Circulation Infarction (POCI): A Comprehensive Analysis of CTP Postprocessing Algorithms for POCI
Optimizing CTP in Posterior Circulation Infarction (POCI): A Comprehensive Analysis of CTP Postprocessing Algorithms for POCI Open
CTP has diagnostic utility in POCI. There were notable differences in optimal parameter and threshold by algorithm. Clinicians should be aware of the specific characteristics of the algorithm used in their CTP software and apply caution wh…
View article: Chronic Disease Management to Enhance Medication Adherence Trajectories in Long‐Term Survivors of Stroke: A Population‐Based Cohort Study
Chronic Disease Management to Enhance Medication Adherence Trajectories in Long‐Term Survivors of Stroke: A Population‐Based Cohort Study Open
Purpose Although chronic disease management (CDM) has been reported to improve medication adherence after stroke or transient ischaemic attack (TIA), the impact on specific patterns of medication adherence is unclear. We aimed to evaluate …
View article: Creation of EmpowerMe, a co-designed website to promote self-efficacy in survivors of stroke (Preprint)
Creation of EmpowerMe, a co-designed website to promote self-efficacy in survivors of stroke (Preprint) Open
BACKGROUND Digital health innovations are frequently used to support people to manage chronic health conditions. Stroke is common, and people who have survived a stroke and live in the community must learn to manage their health independe…
View article: Effect of Thrombolytics on Delayed Reperfusion After Incomplete Thrombectomy
Effect of Thrombolytics on Delayed Reperfusion After Incomplete Thrombectomy Open
This study is rated Class III because it is a nonrandomized study and there are substantial differences in baseline characteristics of the treatment groups.
View article: Conducting descriptive epidemiology and causal inference studies using observational data: A 10-point primer for stroke researchers
Conducting descriptive epidemiology and causal inference studies using observational data: A 10-point primer for stroke researchers Open
Routinely-collected health data and emerging data-linkage capabilities provide researchers and clinicians with rich opportunities to answer important research questions by conducting observational studies. We provide stroke researchers wit…
View article: Accelerating diabetes innovation for real‐world community impact through interdisciplinary research: Who is at the table?
Accelerating diabetes innovation for real‐world community impact through interdisciplinary research: Who is at the table? Open
View article: Costs and Benefits of the Melbourne Mobile Stroke Unit Compared With Standard Ambulance: Causal Analysis Using Observational Linked Data
Costs and Benefits of the Melbourne Mobile Stroke Unit Compared With Standard Ambulance: Causal Analysis Using Observational Linked Data Open
BACKGROUND: Evidence of the cost implications and health outcomes associated with the use of mobile stroke units (MSU) is required to support their utilization. We aimed to evaluate the causal effect of the use of an MSU compared with a st…
View article: Comparative performance of CKD-EPI equations in people with diabetes: An international pooled analysis of individual participant data
Comparative performance of CKD-EPI equations in people with diabetes: An international pooled analysis of individual participant data Open
The use of CKD-EPI equations has the potential for misdiagnosis and suboptimal CKD management in people with diabetes. Alternative methods of estimating kidney function for people with diabetes are needed to optimally manage diabetes-relat…
View article: CLINICALLY PREDICTIVE MODULATION OF COGNITIVE IMPAIRMENTS IN MOUSE TOUCHSCREEN TASKS
CLINICALLY PREDICTIVE MODULATION OF COGNITIVE IMPAIRMENTS IN MOUSE TOUCHSCREEN TASKS Open
Background Cognitive deficits in individuals with schizophrenia present a significant barrier to maintaining interpersonal relationships, employment, and independent living. Moderate to severe impairments have been found in cognitive domai…
View article: ORPHAN GPCRS – A NEW FRONTIER IN SCHIZOPHRENIA DRUG DISCOVERY
ORPHAN GPCRS – A NEW FRONTIER IN SCHIZOPHRENIA DRUG DISCOVERY Open
Background Schizophrenia manifests as a broad and diverse symptomatology that creates a heterogenous patient population that responds to standard of care medicines to varying extents. The three characterised symptom domains; positive, nega…
View article: Nivolumab and rituximab in treatment-naïve follicular lymphoma: the phase 2 1st FLOR study
Nivolumab and rituximab in treatment-naïve follicular lymphoma: the phase 2 1st FLOR study Open
Follicular lymphoma (FL) outcomes are influenced by host immune activity. CD20-directed therapy plus programmed cell death 1 inhibition (PD-1i) increases T-cell tumor killing and natural killer cell antibody-dependent cell cytotoxicity. Mo…
View article: Bridging thrombolysis with tenecteplase versus endovascular thrombectomy alone for large-vessel anterior circulation stroke: a target trial emulation analysis
Bridging thrombolysis with tenecteplase versus endovascular thrombectomy alone for large-vessel anterior circulation stroke: a target trial emulation analysis Open
Background Whether bridging thrombolysis with tenecteplase is beneficial compared with thrombectomy alone in patients who had a stroke with large-vessel occlusion remains unclear. Methods This is a causal inference study of observational d…
View article: Blood biomarker profiles in young-onset neurocognitive disorders: A cohort study
Blood biomarker profiles in young-onset neurocognitive disorders: A cohort study Open
Introduction: Young-onset neurocognitive symptoms result from a heterogeneous group of neurological and psychiatric disorders which present a diagnostic challenge. To identify such factors, we analysed the Biomarkers in Younger-Onset Neuro…
View article: Trajectory of depressive symptoms in a longitudinal stroke cohort
Trajectory of depressive symptoms in a longitudinal stroke cohort Open
Our findings provide evidence for a dynamic trajectory of depressive symptoms in individuals in the first year post-stroke. The importance of repeated screening for depression is highlighted, though most necessary at 3 months post-stroke.
View article: An exploration of serious falls after stroke using a large international stroke rehabilitation database
An exploration of serious falls after stroke using a large international stroke rehabilitation database Open
Background: Falls are common after stroke and can have serious consequences such as hip fracture. Prior research shows around half of individuals will fall within the 12 months post stroke, and these falls are more likely to cause serious …
View article: Assessment of Cardiorespiratory Exercise Training Dose on Brain Health Markers in Sedentary Middle-Aged Adults (The Train Smart Study): A Two-Group Parallel, Open-Label, Phase 2, Blinded-Endpoint, Randomised Trial
Assessment of Cardiorespiratory Exercise Training Dose on Brain Health Markers in Sedentary Middle-Aged Adults (The Train Smart Study): A Two-Group Parallel, Open-Label, Phase 2, Blinded-Endpoint, Randomised Trial Open
View article: A deep learning approach versus expert clinician panel in the classification of posterior circulation infarction
A deep learning approach versus expert clinician panel in the classification of posterior circulation infarction Open