Leonid M. Yermakov
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View article: MicroRNA Profiling Identifies Diagnostic and Prognostic Markers in Pediatric Sarcoma
MicroRNA Profiling Identifies Diagnostic and Prognostic Markers in Pediatric Sarcoma Open
Background: MicroRNAs (miRNAs) function as post-transcriptional gene expression regulators and influence the development and progression of several cancers, yet their roles in pediatric sarcomas remain poorly defined. Methods: RNA extracte…
View article: Distinct Changes in Calpain and Calpastatin during PNS Myelination and Demyelination in Rodent Models
Distinct Changes in Calpain and Calpastatin during PNS Myelination and Demyelination in Rodent Models Open
Myelin forming around axons provides electrical insulation and ensures rapid and efficient transmission of electrical impulses. Disruptions to myelinated nerves often result in nerve conduction failure along with neurological symptoms and …
View article: The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular and Network Levels
The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular and Network Levels Open
Recent evidence suggests that alteration of axon initial segment (AIS) geometry (i.e., length or location along the axon) contributes to CNS dysfunction in neurological diseases. For example, AIS length is shorter in the prefrontal cortex …
View article: The type 2 diabetes factor methylglyoxal mediates axon initial segment shortening and neuronal network activity changes
The type 2 diabetes factor methylglyoxal mediates axon initial segment shortening and neuronal network activity changes Open
Recent evidence suggests that alteration of axon initial segment (AIS) geometry (i.e., length or position along the axon) contributes to CNS dysfunction in neurological diseases. For example, AIS length is shorter in the prefrontal cortex …
View article: Type 2 Diabetes Leads to Impairment of Cognitive Flexibility and Disruption of Excitable Axonal Domains in the Brain
Type 2 Diabetes Leads to Impairment of Cognitive Flexibility and Disruption of Excitable Axonal Domains in the Brain Open
Type 2 diabetes is a metabolic disease affecting millions of people around the world. Cognitive and mood impairments are among its many debilitating complications, but disease mechanism(s) remain elusive. Here, we present a series of behav…
View article: Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice
Type 2 Diabetes Leads to Axon Initial Segment Shortening in db/db Mice Open
Cognitive and mood impairments are common central nervous system complications of type 2 diabetes, although the neuronal mechanism(s) remains elusive. Previous studies focused mainly on neuronal inputs such as altered synaptic plasticity. …
View article: Glial βII Spectrin Contributes to Paranode Formation and Maintenance
Glial βII Spectrin Contributes to Paranode Formation and Maintenance Open
Action potential conduction along myelinated axons depends on high densities of voltage-gated Na+ channels at the nodes of Ranvier. Flanking each node, paranodal junctions (paranodes) are formed between axons and Schwann cells in the perip…
View article: Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation
Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation Open
Nodes of Ranvier and associated paranodal and juxtaparanodal domains along myelinated axons are essential for normal function of the peripheral and central nervous systems. Disruption of these domains as well as increases in the reactive c…
View article: Chronic peripheral nerve compression disrupts paranodal axoglial junctions
Chronic peripheral nerve compression disrupts paranodal axoglial junctions Open
Introduction Peripheral nerves are often exposed to mechanical stress leading to compression neuropathies. The pathophysiology underlying nerve dysfunction by chronic compression is largely unknown. Methods We analyzed molecular organizati…