Leonidas C. Platanias
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View article: Data from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Data from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia Open
We examined the role of SLFN12, a member of the Schlafen (SLFN) family of interferon-regulated genes and proteins in leukemogenesis, and its potential as a therapeutic target in acute myeloid leukemia (AML). We explored the effects of velc…
View article: Supplementary Table S1 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Supplementary Table S1 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia Open
Table S1. Key Resources Table
View article: Figure 6 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Figure 6 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia Open
Antileukemic activity of BAY 2666605 in vivo. A, Schematic representation of the experimental approach for the treatment regimen used for the xenograft AML mouse model. B, Tumor volumes (means ± SEM) are shown for mice…
View article: Figure 5 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Figure 5 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia Open
Effects of velcrin treatment on SLFN12 expression in vivo. A, Schematic representation of the treatment regimen used for the xenograft AML mouse model using BAY 2666605 or vehicle control. B, Tumor growth curves of nud…
View article: Figure 2 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Figure 2 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia Open
Effects of velcrin treatment on leukemic progenitor colony formation. A and B, Clonogenic capability of HEL (A) or U937 (B) cells following treatment with increasing concentrations of BAY 2666605, as noted, for …
View article: Supplementary Figure S3 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Supplementary Figure S3 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia Open
Figure S3. Stable body weight and tumor volume post-BAY treatment in vivo.
View article: Figure 1 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Figure 1 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia Open
SLFN12 expression and velcrin sensitivity of leukemic lines. A, Box plots of SLFN12 mRNA expression in various cancer types analyzed from the TCGA Pan-Cancer dataset using the University of California Santa Cruz Xena Browser …
View article: Figure 3 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Figure 3 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia Open
Effects of velcrin treatment on SLFN12 protein levels, PDE3A/B binding, and induction of cell death. A, HEL cells were treated with vehicle control (DMSO) or with the indicated doses of BAY 2666605 for 4 or 8 hours. Cell lysates wer…
View article: Supplementary Figure S1 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Supplementary Figure S1 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia Open
Figure S1. Dot plot of HEL and U937 cells undergoing apoptosis.
View article: Figure 4 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Figure 4 from Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia Open
Antileukemic effects of the velcrin–Aza combination. A and B, Cell viability of HEL (A) or U937 (B) cells treated with DMSO (vehicle control) or with increasing concentrations of BAY 2666605 (BAY), Aza, or the c…
View article: Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia
Schlafen 12 Modulation and Targeting in Acute Myeloid Leukemia Open
We examined the role of SLFN12, a member of the Schlafen (SLFN) family of interferon-regulated genes and proteins in leukemogenesis, and its potential as a therapeutic target in acute myeloid leukemia (AML). We explored the effects of velc…
View article: Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis
Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis Open
Multicellular circulating tumor cell (CTC) clusters can be up to 50 times more efficient than single CTCs in mediating viable metastasis. Here, combining computational ranking and functional determination, we identify the transmembrane pro…
View article: The ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response
The ubiquitin ligase Triad1 influences myeloid leukemogenesis by regulating the integrated stress response Open
View article: Targeting scavenger receptor class B type 1 with a bioinspired ligand induces apoptosis or ferroptosis in AML
Targeting scavenger receptor class B type 1 with a bioinspired ligand induces apoptosis or ferroptosis in AML Open
Despite progress in research and treatment strategies for acute myeloid leukemia (AML), the prognosis for patients with AML, particularly for individuals aged >60 years and those with adverse risk factors, remains poor. Cellular receptors …
View article: FGFR gene amplification and response to HER2-targeted therapy in patients with HER2-expressing metastatic breast cancer
FGFR gene amplification and response to HER2-targeted therapy in patients with HER2-expressing metastatic breast cancer Open
Purpose Resistance to HER2-targeted therapies remains a major clinical challenge in metastatic breast cancer (MBC), with limited biomarkers to guide treatment. This study sought to evaluate the prognostic and therapeutic significance of FG…
View article: Rare Subset of T Cells Form Heterotypic Clusters with Circulating Tumor Cells to Foster Cancer Metastasis
Rare Subset of T Cells Form Heterotypic Clusters with Circulating Tumor Cells to Foster Cancer Metastasis Open
The immune ecosystem is central to maintaining effective defensive responses. However, how immune cells in the periphery blood interact with circulating tumor cells (CTCs) – seeds of metastasis - remains largely understudied. Here, our ana…
View article: Socioeconomic, racial-ethnic, household, and infrastructural disparities of hematologic cancer outcomes in the United States
Socioeconomic, racial-ethnic, household, and infrastructural disparities of hematologic cancer outcomes in the United States Open
Although social determinants of health (SDoH) investigations have shown limited analyses of socioeconomic and race-ethnic status on certain hematologic malignancies, the impact of factors beyond those across a fuller scope of hematologic c…
View article: Polycomb group protein Mel18 inhibits hematopoietic stem cell self-renewal through repressing the transcription of self-renewal and proliferation genes
Polycomb group protein Mel18 inhibits hematopoietic stem cell self-renewal through repressing the transcription of self-renewal and proliferation genes Open
View article: Supplementary Excel S4 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Excel S4 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Excel S4 shows the list of SNA-pull down glycoproteins detected via glycoproteiomics analysis
View article: Supplementary Figures S1-S17 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Figures S1-S17 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Figure S1-S17 show the methods of CTC analysis and CTC-associated survival (S1); glycosylation profiles of patient CTCs (S2); phenotypic effects of neuraminidase treatment and CD44 depletion on tumor clustering and sialylatio…
View article: Supplementary Video S10 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Video S10 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Video S10 shows the clustering video of siCD97 transfected ST6KO cells presented in Fig.5E.
View article: Supplementary Video S2 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Video S2 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Video S2 shows the clustering video of SNA low cells presented in Fig.2A.
View article: Supplementary Video S3 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Video S3 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Video S3 shows the clustering video of ST6KO cells presented in Fig.2B.
View article: Supplementary Video S13 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Video S13 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Video S13 shows the clustering video of siPODXL transfected ST6KO cells presented in Fig.5E.
View article: Supplementary Video S6 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Video S6 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Video S6 shows the clustering video of PAX treated cells presented in Fig.2E.
View article: Supplementary Video S12 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Video S12 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Video S12 shows the clustering video of siICAM1 transfected ST6KO cells presented in Fig.5E.
View article: Supplementary Excel S4 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Excel S4 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Excel S4 shows the list of SNA-pull down glycoproteins detected via glycoproteiomics analysis
View article: Supplementary Excel S3 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Excel S3 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Excel S3 shows the results of RNA sequencing.
View article: Supplementary Video S17 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Video S17 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Video S17 shows the clustering video of siCD97 transfected ST6WT cells presented in Supplementary Fig.S14B.
View article: Supplementary Video S5 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Supplementary Video S5 from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer Open
Supplementary Video S5 shows the clustering video of ST6WT cells presented in Fig.2B.