Leonie Deppe
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View article: Protection against Oxidative Stress by Coenzyme Q10 in a Porcine Retinal Degeneration Model
Protection against Oxidative Stress by Coenzyme Q10 in a Porcine Retinal Degeneration Model Open
Oxidative stress plays an important role in neurodegenerative diseases, including glaucoma. Therefore, we analyzed if the antioxidant coenzyme Q10 (CoQ10), which is also commercially available, can prevent retinal degeneration induced by h…
View article: Glaucoma Animal Models beyond Chronic IOP Increase
Glaucoma Animal Models beyond Chronic IOP Increase Open
Glaucoma is a complex and multifactorial disease defined as the loss of retinal ganglion cells (RGCs) and their axons. Besides an elevated intraocular pressure (IOP), other mechanisms play a pivotal role in glaucoma onset and progression. …
View article: Progressive Retinal and Optic Nerve Damage in a Mouse Model of Spontaneous Opticospinal Encephalomyelitis
Progressive Retinal and Optic Nerve Damage in a Mouse Model of Spontaneous Opticospinal Encephalomyelitis Open
Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) are antibody mediated CNS disorders mostly affecting the optic nerve and spinal cord with potential severe impact on…
View article: Hypoxic Processes Induce Complement Activation via Classical Pathway in Porcine Neuroretinas
Hypoxic Processes Induce Complement Activation via Classical Pathway in Porcine Neuroretinas Open
Considering the fact that many retinal diseases are yet to be cured, the pathomechanisms of these multifactorial diseases need to be investigated in more detail. Among others, oxidative stress and hypoxia are pathomechanisms that take plac…