Explanipedia

First therapeutic drug monitoring of experimental favipiravir in Borna disease virus 1 (BoDV-1) encephalitis patients reveals significant gaps in antiviral treatment: a pilot investigation Open

Michael Paal, Katharina Habler, Alice Ewert, Michael Vogeser, Leonie Grosse , et al. · 2025

Background The Borna disease virus 1 (BoDV-1) causes a rare, but severe form of encephalitis in Germany, characterized by rapid progression, late diagnosis, and a high case fatality. Therapy is experimental and recommendations are lacking.…

Influence of executive functions on quality of life in Pediatric Epilepsy: A cross-sectional study Open

Lulu Muhe, Elisabeth Kaufmann, Mirjam N. Landgraf, Moritz Tacke, Christine Makowski , et al. · 2025

No differences were found in the overall quality of life between patients with and without executive dysfunction. Nevertheless, executive dysfunction appeared to have a negative impact on some areas of life, such as family and friends, and…

Quality of Life of Children and Adolescents with Epilepsy Compared to Their Healthy Peers: A Cross-Sectional Study Open

Robert Opitz, Miriam Gerstner, Lulu Muhe, Malin Zaddach, Leonie Grosse , et al. · 2025

Epilepsy significantly impacts the health-related quality of life (HRQoL) of children and adolescents (CaA). This study aimed to assess HRQoL in pediatric epilepsy patients compared to their healthy peers, using both self- and proxy-report…

Das therapeutische Potential von niedrig dosiertem Δ9-Tetrahydrocannabinol bei der Modulation der Alzheimer-Pathologie im 5xFAD-Mausmodell Open

Leonie Grosse, Jannek M. Wagner, Caroline Bouter, Nicola Beindorff, Yvonne Bouter · 2025

Antibody Fingerprints Linking Adenoviral Anti-PF4 Disorders Open

Jing Jing Wang, Linda Schönborn, Theodore E. Warkentin, Tim Chataway, Leonie Grosse , et al. · 2024

Kinderneurologische Untersuchung Open

Michaela Bonfert, Johanna Wagner, E. Jung, Leonie Grosse, Victoria Lieftüchter , et al. · 2023

Zusammenfassung Im Alltag von Klinik und Praxis ist der neurologische Status eines Kindes wegweisend: für die differenzialdiagnostische Einordnung bei akuten oder chronischen Fragestellungen ebenso wie für die Beurteilung des Entwicklungss…

Safety and Feasibility of Functional Repetitive Neuromuscular Magnetic Stimulation of the Gluteal Muscles in Children and Adolescents with Bilateral Spastic Cerebral Palsy Open

Leonie Grosse, Julian F. Schnabel, Corinna Börner, Malina A. Späh, Anne C. Meuche , et al. · 2023

Background: For children and adolescents affected by bilateral spastic cerebral palsy (BSCP), non-invasive neurostimulation with repetitive neuromuscular magnetic stimulation (rNMS) combined with physical exercises, conceptualized as funct…

Anti-PF4 immunothrombosis without proximate heparin or adenovirus vector vaccine exposure Open

Linda Schönborn, Olga Esteban, Jan Wesche, Paulina Dobosz, Marta Broto , et al. · 2023

Platelet-activating anti-platelet factor 4 (PF4)/heparin antibodies and anti-PF4 antibodies cause heparin-induced thrombocytopenia (HIT) and vaccine-induced immune thrombocytopenia and thrombosis (VITT), respectively. Diagnostic and treatm…

Functional Repetitive Neuromuscular Magnetic Stimulation (frNMS) Targeting the Tibialis Anterior Muscle in Children with Upper Motor Neuron Syndrome: A Feasibility Study Open

Leonie Grosse, Anne C. Meuche, Barbara Parzefall, Corinna Börner, Julian F. Schnabel , et al. · 2023

Non-invasive neurostimulation as an adjunctive intervention to task-specific motor training is an approach to foster motor performance in patients affected by upper motor neuron syndrome (UMNS). Here, we present first-line data of repetiti…

Addressing gross motor function by functional repetitive neuromuscular magnetic stimulation targeting to the gluteal muscles in children with bilateral spastic cerebral palsy: benefits of functional repetitive neuromuscular magnetic stimulation targeting the gluteal muscles Open

Leonie Grosse, Malina A. Späh, Corinna Börner, Julian F. Schnabel, Anne C. Meuche , et al. · 2023

Background Impaired selective motor control, weakness and spasticity represent the key characteristics of motor disability in the context of bilateral spastic cerebral palsy. Independent walking ability is an important goal and training of…

First detected geographical cluster of BoDV-1 encephalitis from same small village in two children: therapeutic considerations and epidemiological implications Open

Leonie Grosse, Victoria Lieftüchter, Yannik Vollmuth, Florian Hoffmann, Martin Olivieri , et al. · 2023

Background The Borna disease virus (BoDV-1) is an emerging zoonotic virus causing severe and mostly fatal encephalitis in humans. Methods and Results A local cluster of fatal BoDV-1 encephalitis cases was detected in the same village three…

Heparin- and Vaccine-Independent Anti-Platelet Factor 4 Immunothrombosis Open

Linda Schönborn, Olga Esteban, Jan Wesche, Paulina Dobosz, Marta Broto , et al. · 2023

Targeted Molecular Strategies for Genetic Neurodevelopmental Disorders: Emerging Lessons from Dravet Syndrome Open

Robert Lersch, Rawan Jannadi, Leonie Grosse, Matias Wagner, Marius Frederik Schneider , et al. · 2022

Dravet syndrome is a severe developmental and epileptic encephalopathy mostly caused by heterozygous mutation of the SCN1A gene encoding the voltage-gated sodium channel α subunit Na v 1.1. Multiple seizure types, cognitive deterioration, …

Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells Open

Markus Zwick, Thomas Ulas, Yi-Li Cho, Christine Ried, Leonie Grosse , et al. · 2019

Apoptotic cell death of Dendritic cells (DCs) is critical for immune homeostasis. Although intrinsic mechanisms controlling DC death have not been fully characterized up to now, experimentally enforced inhibition of DC-death causes various…

Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8<sup>+</sup>Dendritic Cells Open

Markus Zwick, Thomas Ulas, Yi-Li Cho, Christine Ried, Leonie Grosse , et al. · 2018

Apoptotic cell death of Dendritic cells (DCs) is critical for immune homeostasis. Although intrinsic mechanisms controlling DC death have not been fully characterized up to now, experimentally enforced inhibition of DC-death causes various…

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