Leonie Küchenhoff
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View article: Analyzing single-cell bisulfite sequencing data with MethSCAn
Analyzing single-cell bisulfite sequencing data with MethSCAn Open
Single-cell bisulfite sequencing (scBS) is a technique that enables the assessment of DNA methylation at single-base pair and single-cell resolution. The analysis of large datasets obtained from scBS requires preprocessing to reduce the da…
View article: Complementing Cell Taxonomies with a Multicellular Analysis of Tissues
Complementing Cell Taxonomies with a Multicellular Analysis of Tissues Open
The application of single-cell molecular profiling coupled with spatial technologies has enabled charting of cellular heterogeneity in reference tissues and in disease. This new wave of molecular data has highlighted the expected diversity…
View article: The population context is a driver of the heterogeneous response of epithelial cells to interferons
The population context is a driver of the heterogeneous response of epithelial cells to interferons Open
Isogenic cells respond in a heterogeneous manner to interferon. Using a micropatterning approach combined with high-content imaging and spatial analyses, we characterized how the population context (position of a cell with respect to neigh…
View article: Extended methods for spatial cell classification with DBSCAN-CellX
Extended methods for spatial cell classification with DBSCAN-CellX Open
Local cell densities and positioning within cellular monolayers and stratified epithelia have important implications for cell interactions and the functionality of various biological processes. To analyze the relationship between cell loca…
View article: Population context drives cell-to-cell variability in interferon response in epithelial cells
Population context drives cell-to-cell variability in interferon response in epithelial cells Open
Isogenic cells respond in a heterogeneous manner to interferon. Using a micropatterning approach combined with high-content imaging and spatial analyses, we characterized how the population context (position of a cell with respect to the n…
View article: Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy Open
Dilated cardiomyopathy (DCM) is the second most common cause for heart failure with no cure except a high-risk heart transplantation. Approximately 30% of DCM patients harbor heritable mutations which are amenable to CRISPR-based gene ther…
View article: Analyzing single-cell bisulfite sequencing data with<i>MethSCAn</i>
Analyzing single-cell bisulfite sequencing data with<i>MethSCAn</i> Open
Single-cell bisulfite sequencing (scBS) is a technique that enables the assessment of DNA methylation at single-base pair and single-cell resolution. The analysis of large datasets obtained from scBS requires preprocessing to reduce data s…