Leonie Rieger
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View article: Boosting CAR T-Cell Efficacy by Blocking Proteasomal Degradation of Membrane Antigens
Boosting CAR T-Cell Efficacy by Blocking Proteasomal Degradation of Membrane Antigens Open
Chimeric antigen receptor (CAR) T cells exhibit high response rates in B cell malignancies, but most patients eventually relapse. A key mechanism of treatment failure is the loss or downregulation of tumor antigen expression, yet strategie…
View article: β1-integrin controls IGF-1R internalization and intracellular signaling
β1-integrin controls IGF-1R internalization and intracellular signaling Open
View article: Engineering de novo binder CAR-T cell therapies with generative AI
Engineering de novo binder CAR-T cell therapies with generative AI Open
Chimeric antigen receptor T cell (CAR-T) therapies have revolutionized cancer treatment, with six CAR-T products currently in clinical use 1–4 . Despite their success, high resistance rates due to antigen escape remain a major challenge 5,…
View article: B-cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B-cell transformation
B-cell intrinsic RANK signaling cooperates with TCL1 to induce lineage-dependent B-cell transformation Open
B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and multiple myeloma (MM), remain incurable, with MM particularly prone to relapse. Our study introduces a novel mouse model with active RANK signaling and the TCL1 oncogene, …
View article: Actionable loss of <scp>SLF2</scp> drives B‐cell lymphomagenesis and impairs the <scp>DNA</scp> damage response
Actionable loss of <span>SLF2</span> drives B‐cell lymphomagenesis and impairs the <span>DNA</span> damage response Open
View article: Controlled Signaling—Insulin-Like Growth Factor Receptor Endocytosis and Presence at Intracellular Compartments
Controlled Signaling—Insulin-Like Growth Factor Receptor Endocytosis and Presence at Intracellular Compartments Open
Ligand-induced activation of the IGF-1 receptor triggers plasma-membrane-derived signal transduction but also triggers receptor endocytosis, which was previously thought to limit signaling. However, it is becoming ever more clear that IGF-…
View article: IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr <sup>1250</sup> and Tyr <sup>1251</sup>
IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr <sup>1250</sup> and Tyr <sup>1251</sup> Open
Translocation of the IGF-1 receptor to the Golgi promotes cancer cell migration.
View article: Regulation of insulin-like growth factor receptor activity and its therapeutic targeting in cancer
Regulation of insulin-like growth factor receptor activity and its therapeutic targeting in cancer Open
Insulin-like Growth Factor-1 Receptor signalling is essential for cell growth, and also promotes migration, survival and cellular transformation, thus, linking it to cancer progression. IGF-1R activity and signalling in cancer cells is reg…
View article: Cell wall composition and penetration resistance against the fungal pathogen<i>Colletotrichum higginsianum</i>are affected by impaired starch turnover in Arabidopsis mutants
Cell wall composition and penetration resistance against the fungal pathogen<i>Colletotrichum higginsianum</i>are affected by impaired starch turnover in Arabidopsis mutants Open
Penetration resistance represents the first level of plant defense against phytopathogenic fungi. Here, we report that the starch-deficient Arabidopsis thaliana phosphoglucomutase (pgm) mutant has impaired penetration resistance against th…