Leonore Wigger
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View article: A multiorgan map of metabolic, signaling, and inflammatory pathways that coordinately control fasting glycemia in mice
A multiorgan map of metabolic, signaling, and inflammatory pathways that coordinately control fasting glycemia in mice Open
View article: lncRNA transcriptomics
lncRNA transcriptomics Open
Files for upload to the UCSC Genome Browser
View article: lncRNA transcriptomics
lncRNA transcriptomics Open
Files for upload to the UCSC Genome Browser
View article: Cortical <i>miR-709</i> links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner
Cortical <i>miR-709</i> links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner Open
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that have been implicated in a plethora of neuronal processes. Nevertheless, their role in regulating brain activity in the context of sleep has so far received …
View article: Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies <i>FIXER</i> , a Conserved Profibrogenic Long Noncoding RNA
Assessment of the Cardiac Noncoding Transcriptome by Single-Cell RNA Sequencing Identifies <i>FIXER</i> , a Conserved Profibrogenic Long Noncoding RNA Open
BACKGROUND: Cardiac fibroblasts have crucial roles in the heart. In particular, fibroblasts differentiate into myofibroblasts in the damaged myocardium, contributing to scar formation and interstitial fibrosis. Fibrosis is associated with …
View article: Two metabolomics data sets (mouse kidney, mouse plasma), generated for the publication Bignon et al., 2023: "Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock".
Two metabolomics data sets (mouse kidney, mouse plasma), generated for the publication Bignon et al., 2023: "Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock". Open
Publication: Bignon Y, Wigger L, Ansermet C, Weger BD, Lagarrigue S, Centeno G, Durussel F, Götz L, Ibberson M, Pradervand S, Quadroni M, Weger M, Amati F, Gachon F, Firsov D. Multiomics reveals multilevel control of renal…
View article: Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock
Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock Open
Circadian rhythmicity in renal function suggests rhythmic adaptations in renal metabolism. To decipher the role of the circadian clock in renal metabolism, we studied diurnal changes in renal metabolic pathways using integrated transcripto…
View article: Two metabolomics data sets (mouse kidney, mouse plasma), generated for the publication Bignon et al., 2023: "Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock".
Two metabolomics data sets (mouse kidney, mouse plasma), generated for the publication Bignon et al., 2023: "Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock". Open
Publication: Bignon Y, Wigger L, Ansermet C, Weger BD, Lagarrigue S, Centeno G, Durussel F, Götz L, Ibberson M, Pradervand S, Quadroni M, Weger M, Amati F, Gachon F, Firsov D. Multiomics reveals multilevel control of renal…
View article: A combination of plasma membrane sterol biosynthesis and autophagy is required for shade-induced hypocotyl elongation
A combination of plasma membrane sterol biosynthesis and autophagy is required for shade-induced hypocotyl elongation Open
View article: Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner
Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner Open
MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression that have been implicated in a plethora of neuronal processes. Nevertheless, their role in regulating brain activity in the context of sleep has so far received …
View article: Plasma triacylglycerols are biomarkers of β-cell function in mice and humans
Plasma triacylglycerols are biomarkers of β-cell function in mice and humans Open
View article: Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes Open
View article: Reduced light access promotes hypocotyl growth via autophagy-mediated recycling
Reduced light access promotes hypocotyl growth via autophagy-mediated recycling Open
SUMMARY Plant growth ultimately depends on fixed carbon, thus the available light for photosynthesis. Due to canopy light absorption properties, vegetative shade combines reduced light and a low red to far-red ratio (LRFR). In shade-avoidi…
View article: Two lipidomics data sources for the publication "Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes"
Two lipidomics data sources for the publication "Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes" Open
Abstract: Wigger, Barovic, Brunner et al present a comprehensive multi-omics analysis of pancreatic islets obtained from metabolically profiled pancreatectomized living human donors stratified along the glycemic continuum,…
View article: Two lipidomics data sources for the publication "Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes"
Two lipidomics data sources for the publication "Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes" Open
Abstract: Wigger, Barovic, Brunner et al present a comprehensive multi-omics analysis of pancreatic islets obtained from metabolically profiled pancreatectomized living human donors stratified along the glycemic continuum,…
View article: Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes
Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetes Open
Existing studies do not sufficiently describe the molecular changes of pancreatic islet beta cells leading to their deficient insulin secretion in type 2 diabetes (T2D). Here we address this deficiency with a comprehensive multi-omics anal…
View article: Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients
Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients Open
View article: Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine
Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine Open
The examples developed in this review will highlight the power of the systems biology approach, in particular as it allowed the discovery of dihydroceramide as a T2D biomarker candidate in mice and humans and the identification and charact…
View article: System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells
System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells Open
Transcriptional regulations exert a critical control of metabolic homeostasis. In particular, the nuclear receptors (NRs) are involved in regulating numerous pathways of the intermediate metabolism. The purpose of the present study was to …
View article: Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort
Dairy consumption is associated with lower plasma dihydroceramides in women from the D.E.S.I.R. cohort Open
View article: Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system
Sensory neuron lineage mapping and manipulation in the Drosophila olfactory system Open
View article: Sensory neuron lineage mapping and manipulation in the<i>Drosophila olfactory</i>system
Sensory neuron lineage mapping and manipulation in the<i>Drosophila olfactory</i>system Open
Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-interrogate specific lineages, especially at early developmental stages prior to expression o…
View article: Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes Open
View article: Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans
Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans Open
View article: Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion Open
View article: A Neuron-Specific Deletion of the MicroRNA-Processing Enzyme DICER Induces Severe but Transient Obesity in Mice
A Neuron-Specific Deletion of the MicroRNA-Processing Enzyme DICER Induces Severe but Transient Obesity in Mice Open
MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression post-transcriptionally. MiRNAs are implicated in various biological processes associated with obesity, including adipocyte differentiation and lipid metab…