Lepu Zhou
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View article: Rapid astroglial stress response and elevation of endogenous BiP levels promote neuronal survival in hippocampal slice cultures
Rapid astroglial stress response and elevation of endogenous BiP levels promote neuronal survival in hippocampal slice cultures Open
A hallmark of neurodegenerative diseases is the accumulation of protein aggregates, the formation of which is prevented by chaperone proteins. BiP is the central chaperone in the endoplasmic reticulum. In this study we investigated the pat…
View article: Rapid astroglial stress response and elevation of endogenous BiP levels promote neuronal survival in hippocampal slice cultures
Rapid astroglial stress response and elevation of endogenous BiP levels promote neuronal survival in hippocampal slice cultures Open
A hallmark of neurodegenerative diseases is the accumulation of protein aggregates, the formation of which is prevented by chaperone proteins. BiP is the central chaperone in the endoplasmic reticulum. In this study we investigated the pat…
View article: Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids
Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids Open
Numerous studies provide increasing evidence, which supports the ideas that every cell in the brain of males may differ from those in females due to differences in sex chromosome complement as well as in response to hormonal effects. In th…
View article: The serine protease inhibitor neuroserpin is required for normal synaptic plasticity and regulates learning and social behavior
The serine protease inhibitor neuroserpin is required for normal synaptic plasticity and regulates learning and social behavior Open
The serine protease inhibitor neuroserpin regulates the activity of tissue-type plasminogen activator (tPA) in the nervous system. Neuroserpin expression is particularly prominent at late stages of neuronal development in most regions of t…
View article: Sex-Dependent Regulation of Aromatase-Mediated Synaptic Plasticity in the Basolateral Amygdala
Sex-Dependent Regulation of Aromatase-Mediated Synaptic Plasticity in the Basolateral Amygdala Open
The basolateral amygdala (BLA) integrates sensory input from cortical and subcortical regions, a function that requires marked synaptic plasticity. Here we provide evidence that cytochrome P450 aromatase (AROM), the enzyme converting testo…
View article: Neurodegeneration and <scp>NLRP3</scp> inflammasome expression in the anterior thalamus of <scp>SOD1(G93A) ALS</scp> mice
Neurodegeneration and <span>NLRP3</span> inflammasome expression in the anterior thalamus of <span>SOD1(G93A) ALS</span> mice Open
Nowadays, amyotrophic lateral sclerosis (ALS) is considered as a multisystem disorder, characterized by a primary degeneration of motor neurons as well as neuropathological changes in non‐motor regions. Neurodegeneration in subcortical are…
View article: Synaptopodin is regulated by aromatase activity
Synaptopodin is regulated by aromatase activity Open
Locally synthesized estradiol plays an important role in synaptic plasticity in the hippocampus. We have previously shown that in hippocampal neurons, activity of the enzyme aromatase, which converts testosterone into estradiol, is reduced…