Lisheng Peng
YOU?
Author Swipe
View article: Machine learning-based model for acute asthma exacerbation detection using routine blood parameters
Machine learning-based model for acute asthma exacerbation detection using routine blood parameters Open
Not applicable.
View article: Different cerebrospinal fluid drainage methods and chronic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage
Different cerebrospinal fluid drainage methods and chronic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage Open
Background Chronic hydrocephalus represents a common complication following aneurysmal subarachnoid hemorrhage (aSAH); however, the underlying mechanisms driving its pathogenesis remain incompletely understood. Furthermore, current evidenc…
View article: A Self‐Supporting Flexible Electrode for Tracking and Reversible Quantification of Mg<sup>2+</sup> and Ca<sup>2+</sup> in the Brains of Freely Behaving Animal
A Self‐Supporting Flexible Electrode for Tracking and Reversible Quantification of Mg<sup>2+</sup> and Ca<sup>2+</sup> in the Brains of Freely Behaving Animal Open
Monitoring dynamic neurochemical signals in the brain of free‐moving animals remains great challenging in biocompatibility and direct implantation capability of current electrodes. Here we created a self‐supporting polymer‐based flexible m…
View article: The central helicase domain holds the major conformational epitopes of melanoma differentiation–associated gene 5 autoantibodies
The central helicase domain holds the major conformational epitopes of melanoma differentiation–associated gene 5 autoantibodies Open
Objective Autoantibodies against MDA5 (melanoma differentiation-associated protein 5) serve as a biomarker for DM (dermatomyositis) and indicate a risk factor for interstitial lung disease (ILD). MDA5 is a protein responsible for sensing R…
View article: Increased Cerebellum <scp><sup>18</sup>F‐DPA</scp>‐714 Uptake in <scp>Anti‐Glutamate Kainate Receptor Subunit 2</scp> Autoimmune Encephalitis
Increased Cerebellum <span><sup>18</sup>F‐DPA</span>‐714 Uptake in <span>Anti‐Glutamate Kainate Receptor Subunit 2</span> Autoimmune Encephalitis Open
Anti-glutamate kainate receptor subunit 2 (Gluk2) autoimmune encephalitis (AE) is a novel and very rare neuroimmune disease that was first reported in 2021.1 Eight patients with this rare form of AE have been reported globally.1 Herein, we…
View article: Immune Checkpoint Inhibitor Associated Autoimmune Encephalitis, Rare and Novel Topic of Neuroimmunology: A Case Report and Review of the Literature
Immune Checkpoint Inhibitor Associated Autoimmune Encephalitis, Rare and Novel Topic of Neuroimmunology: A Case Report and Review of the Literature Open
Immune checkpoint inhibitors (ICIs) are being used in patients with various advanced malignancies, and patient outcomes have improved considerably. Although ICIs can effectively treat tumors, 30–60% of patients experience immune-related ad…
View article: Anti-IgLON5 antibodies cause progressive behavioral and neuropathological changes in mice
Anti-IgLON5 antibodies cause progressive behavioral and neuropathological changes in mice Open
Background Anti-IgLON5 disease is a rare neurological disorder associated with autoantibodies against the neuronal cell adhesion protein, IgLON5. Cellular investigations with human IgLON5 antibodies have suggested an antibody-mediated path…
View article: Caffeic Acid Phenethyl Ester Protects against Experimental Autoimmune Encephalomyelitis by Regulating T Cell Activities
Caffeic Acid Phenethyl Ester Protects against Experimental Autoimmune Encephalomyelitis by Regulating T Cell Activities Open
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) characterized by progressive demyelination and disabling outcomes. CD4 + T cells are the most critical driving factor of relapsing MS, but li…
View article: Astrocyte-derived VEGF increases cerebral microvascular permeability under high salt conditions
Astrocyte-derived VEGF increases cerebral microvascular permeability under high salt conditions Open
Excess salt (NaCl) intake is closely related to a variety of central nervous system (CNS) diseases characterized by increased cerebral microvascular permeability. However, the link between a high salt diet (HSD) and the breakdown of tight …
View article: Different Exosomal microRNA Profile in Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorders
Different Exosomal microRNA Profile in Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorders Open
Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) are inflammatory demyelinating diseases of the central nervous system. Exosomal microRNAs (miRNAs) are emerging biomarkers for demyelinating diseases. In this stud…
View article: Myelin oligodendrocyte glycoprotein-associated disorders are associated with HLA subtypes in a Chinese paediatric-onset cohort
Myelin oligodendrocyte glycoprotein-associated disorders are associated with HLA subtypes in a Chinese paediatric-onset cohort Open
Objective Myelin oligodendrocyte glycoprotein-associated disorders (MOGADs) are a rare new neurological autoimmune disease with unclear pathogenesis. Since a linkage of the disease to the human leucocyte antigen (HLA) has not been shown, w…
View article: Identification of Medium-Length Antineurofilament Autoantibodies in Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Identification of Medium-Length Antineurofilament Autoantibodies in Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis Open
Anti-NFM autoantibodies may be present in patients with anti-NMDAR encephalitis, indicating underlying neuronal damage. A large cohort study is warranted to investigate the clinical differences between patients with NMDAR encephalitis acco…
View article: The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke
The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke Open
Background Preserving the integrity of the blood-brain barrier (BBB) is beneficial to avoid further brain damage after acute ischemic stroke (AIS). Astrocytes, an important component of the BBB, promote BBB breakdown in subjects with AIS b…
View article: Seizure and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Encephalomyelitis in a Retrospective Cohort of Chinese Patients
Seizure and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Encephalomyelitis in a Retrospective Cohort of Chinese Patients Open
Background: Myelin oligodendrocyte glycoprotein (MOG) antibody associated encephalomyelitis is increasingly being considered a distinct disease entity, with seizures and encephalopathy commonly reported. We investigated the clinical featur…
View article: Dysregulated MicroRNA Involvement in Multiple Sclerosis by Induction of T Helper 17 Cell Differentiation
Dysregulated MicroRNA Involvement in Multiple Sclerosis by Induction of T Helper 17 Cell Differentiation Open
Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. Growing evidence has proven that T helper 17 (Th17) cells are one of the regulators of neuroinflammation mechanisms in MS disease. Researche…
View article: Targeted homing of CCR2-overexpressing mesenchymal stromal cells to ischemic brain enhances post-stroke recovery partially through PRDX4-mediated blood-brain barrier preservation
Targeted homing of CCR2-overexpressing mesenchymal stromal cells to ischemic brain enhances post-stroke recovery partially through PRDX4-mediated blood-brain barrier preservation Open
Rationale: Mesenchymal stromal cells (MSCs) are emerging as a novel therapeutic strategy for the acute ischemic stroke (AIS). However, the poor targeted migration and low engraftment in ischemic lesions restrict their treatment efficacy. T…
View article: Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity
Proteasome-independent polyubiquitin linkage regulates synapse scaffolding, efficacy, and plasticity Open
Significance A well-investigated mechanism regulating synapse protein turnover and remodeling is the classical ubiquitin–proteasome system by which polyubiquitin (polyUb) chains linked through ubiquitin lysine 48 (K48) tag substrates for p…
View article: Risk Factors and Clinical Manifestations of Juxtacortical Small Lesions: A Neuroimaging Study
Risk Factors and Clinical Manifestations of Juxtacortical Small Lesions: A Neuroimaging Study Open
These data suggest that JCSLs are symptomatic and might in result fromarteriole atherosclerosis, which should raise our attention.
View article: A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding
A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding Open
Antibody treatment is currently the only available countermeasure for botulism, a fatal illness caused by flaccid paralysis of muscles due to botulinum neurotoxin (BoNT) intoxication. Among the seven major serotypes of BoNT/A-G, BoNT/A pos…
View article: Fatal familial insomnia with abnormal signals on routine MRI: a case report and literature review
Fatal familial insomnia with abnormal signals on routine MRI: a case report and literature review Open
This case is a compelling example that even with evidence of leukoencephalopathy, prion disease should be an important differential diagnosis of rapidly progressive dementia and related diseases. In cases of genetic diseases with atypical …
View article: High salt-induced activation and expression of inflammatory cytokines in cultured astrocytes
High salt-induced activation and expression of inflammatory cytokines in cultured astrocytes Open
Salt (sodium chloride, NaCl) accumulation in the brain is associated with various diseases of central nervous system (CNS). Activation of astrocytes is an important manifestation of pathophysiological processes in the CNS. However, the dir…