Jyoti Kumari
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View article: Genotypic variability for root nodulation and identification of high yielding chickpea (Cicer arietinum L.) genotypes
Genotypic variability for root nodulation and identification of high yielding chickpea (Cicer arietinum L.) genotypes Open
Evaluating diverse chickpea genotypes for growth, root nodule, and yield parameters can provide valuable insights to identify genotypes with desirable traits for improved crop production. The investigation on root nodule parameters can she…
View article: Prefoldins are novel regulators of molecular mechanism associated with unfolded protein response in artemisinin resistant P. falciparum malaria
Prefoldins are novel regulators of molecular mechanism associated with unfolded protein response in artemisinin resistant P. falciparum malaria Open
Emerging Artemisinin (ART) resistance in Plasmodium demands novel drugs that can target artemisinin resistance mechanism to manage resistant parasites. ART resistance is attributed by mutations in the Plasmodium falciparum (Pf) Kelch-13 (P…
View article: Variation in Antimicrobial Activity and Seed Storage Proteins in Three Species of the Medicinal Plant Alstonia
Variation in Antimicrobial Activity and Seed Storage Proteins in Three Species of the Medicinal Plant Alstonia Open
The family Apocynaceae comprises three species of the substantially important Alstonia plant, viz., A. scholaris, A. venenata, and A. macrophylla. The investigation of proteins contained within seeds, that has the potential to provide both…
View article: Targeting an essential Plasmodium cold shock protein to block growth and transmission of malaria parasite
Targeting an essential Plasmodium cold shock protein to block growth and transmission of malaria parasite Open
Cold shock proteins are characterized by the presence of one or more cold shock domains that bestow them with nucleic acid binding ability. Although cold shock proteins are well characterized in bacteria, plants and humans, there is no inf…
View article: Targeting Artemisinin-Resistant Malaria by Repurposing the Anti-Hepatitis C Virus Drug Alisporivir
Targeting Artemisinin-Resistant Malaria by Repurposing the Anti-Hepatitis C Virus Drug Alisporivir Open
The emergence of Plasmodium falciparum resistance raises an urgent need to find new antimalarial drugs. Here, we report the rational repurposing of the anti-hepatitis C virus drug, alisporivir, a nonimmunosuppressive analog of cyclosporin …
View article: Studying the Rationale of Fire Ant Sting Therapy Usage by the Tribal Natives of Bastar Revealed Ant Venom-Derived Peptides with Promising Anti-Malarial Activity
Studying the Rationale of Fire Ant Sting Therapy Usage by the Tribal Natives of Bastar Revealed Ant Venom-Derived Peptides with Promising Anti-Malarial Activity Open
Prevailing drug resistance in malaria imposes the major roadblock for the existing interventions necessitating the timely need to search for alternative therapies. Ants in Solenopsis spp, termed ’Fire ants’, are well known for their aggres…
View article: Screening of catharanthus roseus stem extract for anti-ulcer potential in wistar rat
Screening of catharanthus roseus stem extract for anti-ulcer potential in wistar rat Open
This study aims to evaluate the anti-ulcer effect of Catharanthus roseus Stem extract on gastric ulcers caused by forced swimming. It was investigated that Catharanthus roseus having many kinds of phytochemical constituents so it is respon…
View article: ‘Erythritol’, a safe natural sweetener exhibits multi-stage anti-malarial activity by blocking <i>Plasmodium falciparum</i> membrane transporter ‘aquaporin’
‘Erythritol’, a safe natural sweetener exhibits multi-stage anti-malarial activity by blocking <i>Plasmodium falciparum</i> membrane transporter ‘aquaporin’ Open
The increased resistance of human malaria parasite Plasmodium falciparum to currently used drugs necessities the development of novel anti-malarials. In the present study, we examine the potential of erythritol, a sugar substitute, for the…
View article: Study on Zooplankton Diversity in A Fresh Water Pond (Raja Bandh) of Jamtara, Jharkhand, India
Study on Zooplankton Diversity in A Fresh Water Pond (Raja Bandh) of Jamtara, Jharkhand, India Open
Zooplankton are cosmopolitan in nature and one of the most important ecological parameter in water quality assessment because they help in disposal of sewage and act as natural purifiers of water. Present study was carried out for a period…
View article: Targeting the artemisinin resistant malaria by repositioning of the anti-Hepatitis C Virus drug Alisporivir
Targeting the artemisinin resistant malaria by repositioning of the anti-Hepatitis C Virus drug Alisporivir Open
The rapid emergence of P. falciparum-resistant strains raises an urgent need to find new antimalarial drug candidates. This study reports the rational repositioning of the anti-Hepatitis C Virus drug, Alisporivir, a non-immunosuppressive a…
View article: A small bioactive glycoside inhibits epsilon toxin and prevents cell death
A small bioactive glycoside inhibits epsilon toxin and prevents cell death Open
Clostridium perfringens epsilon toxin (Etx) is categorized as the third most lethal bioterrorism agent by the Centers for Disease Control and Prevention (CDC), with no therapeutic counter measures available for humans. Here, we have develo…
View article: Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery
Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery Open
GluK3-kainate receptors are atypical members of the iGluR family that reside at both the pre- and postsynapse and play a vital role in the regulation of synaptic transmission. For a better understanding of structural changes that underlie …
View article: Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery.
Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery. Open
GluK3-kainate receptors are atypical members of the iGluR family that reside at both the pre- and postsynapse and play a vital role in the regulation of synaptic transmission. For a better understanding of structural changes that underlie …
View article: Structural Insights into GluK3-kainate Receptor Desensitization and Recovery
Structural Insights into GluK3-kainate Receptor Desensitization and Recovery Open
GluK3-kainate receptors are atypical members of the iGluR family that reside at both the pre- and postsynapse and play key role in regulation of synaptic transmission. For better understanding of structural changes that underlie receptor r…
View article: Evaluation of peptide designing strategy against subunit reassociation in mucin 1: A steered molecular dynamics approach
Evaluation of peptide designing strategy against subunit reassociation in mucin 1: A steered molecular dynamics approach Open
Subunit reassociation in mucin 1, a breast cancer tumor marker, is reported as one of the critical factors for its cytoplasmic activation. Inhibition of its heterodimeric association would therefore result in loss of its function and alter…
View article: Overexpression of SbSI-1, A Nuclear Protein from Salicornia brachiata Confers Drought and Salt Stress Tolerance and Maintains Photosynthetic Efficiency in Transgenic Tobacco
Overexpression of SbSI-1, A Nuclear Protein from Salicornia brachiata Confers Drought and Salt Stress Tolerance and Maintains Photosynthetic Efficiency in Transgenic Tobacco Open
A novel Salicornia brachiata Salt Inducible (SbSI-1) gene was isolated and overexpressed in tobacco for in planta functional validation subjected to drought and salt stress. SbSI-1 is a nuclear protein. The transgenic tobacco overexpressin…
View article: Casting the critical regions in nucleotide binding oligomerization domain 2 protein: a signature mediated structural dynamics approach
Casting the critical regions in nucleotide binding oligomerization domain 2 protein: a signature mediated structural dynamics approach Open
Nucleotide binding oligomerization domain 2 (NOD2), a protein involved in the first line defence mechanism has a pivotal role in innate immunity. Impaired function of this protein is implicated in disorders such as Blau syndrome and Crohn’…