Lesley Berk
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View article: Addressing the unmet needs of bipolar disorder in Australia and beyond
Addressing the unmet needs of bipolar disorder in Australia and beyond Open
People impacted by bipolar disorder are confronted by many unmet needs that contribute to the overall burden associated with the disorder. We do not have a good understanding of the underlying pathology of bipolar disorder, so we do not ha…
View article: An ISBD perspective on the sociocultural challenges of managing bipolar disorder: A content analysis
An ISBD perspective on the sociocultural challenges of managing bipolar disorder: A content analysis Open
OBJECTIVE: Clinical management of bipolar disorder patients might be affected by culture and is further dependent on the context of healthcare delivery. There is a need to understand how healthcare best can be delivered in various systems …
View article: Prevalence and Predictors of Older Adults’ Computer Use: A Longitudinal Analysis of the ALSOP Cohort (Preprint)
Prevalence and Predictors of Older Adults’ Computer Use: A Longitudinal Analysis of the ALSOP Cohort (Preprint) Open
BACKGROUND The role of technology in accessing resources/services for managing everyday activities is rapidly advancing. Although research suggests the digital divide between generations has decreased, most older adults remain less engage…
View article: Harnessing the potential of community-based participatory research approaches in bipolar disorder
Harnessing the potential of community-based participatory research approaches in bipolar disorder Open
The quantity and sophistication of research on bipolar disorder (BD) has expanded rapidly in the past decade. Despite progress, the field faces challenges in improving individuals' quality of life (QoL) and symptom outcomes, adapting treat…
View article: Experiences of Interpersonal Emotion Regulation for People with Heightened Emotions: An Examination in People with Bipolar Disorder and Those with High Aggression
Experiences of Interpersonal Emotion Regulation for People with Heightened Emotions: An Examination in People with Bipolar Disorder and Those with High Aggression Open
Most research on interpersonal emotion regulation (IER) has focused on nonclinical samples. On one hand, people with clinically significant emotion, mood, or interpersonal difficulties may encounter more challenges with IER. On the other h…
View article: Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management
Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management Open
Populations with common physical diseases – such as cardiovascular diseases, cancer and neurodegenerative disorders – experience substantially higher rates of major depressive disorder (MDD) than the general population. On the other hand, …
View article: Exploring Clinical Subgroups of Participants with Major Depressive Disorder that may Benefit from Adjunctive Minocycline Treatment
Exploring Clinical Subgroups of Participants with Major Depressive Disorder that may Benefit from Adjunctive Minocycline Treatment Open
: Understanding the relationship between MDD and illness chronicity, comorbid systemic illness, and adverse effects, can potentially better characterise those individuals who are more likely to respond to adjunctive anti-inflammatory medic…
View article: Distress, burden, and wellbeing in siblings of people with mental illness: a mixed studies systematic review and meta-analysis
Distress, burden, and wellbeing in siblings of people with mental illness: a mixed studies systematic review and meta-analysis Open
Background Family members of people with mental illness (MI) may experience a host of psychological adversities such as increased stress, burden, and reduced wellbeing. However, relatively little is known about siblings. This study aimed t…
View article: Minocycline as Treatment for Psychiatric and Neurological Conditions: A Systematic Review and Meta-Analysis
Minocycline as Treatment for Psychiatric and Neurological Conditions: A Systematic Review and Meta-Analysis Open
Minocycline has anti-inflammatory, antioxidant, and anti-apoptotic properties that explain the renewed interest in its use as an adjunctive treatment for psychiatric and neurological conditions. Following the completion of several new clin…
View article: Adjunctive minocycline for major depressive disorder: A sub-study exploring peripheral immune-inflammatory markers and associated treatment response
Adjunctive minocycline for major depressive disorder: A sub-study exploring peripheral immune-inflammatory markers and associated treatment response Open
Change in complement C3, IL-1Ra, IL-8/CXCL8, and ICAM-1 may be associated with greater change in depressive scores following adjunctive minocycline treatment in MDD. Further investigations are needed to assess the utility of these biomarke…
View article: Coping with COVID-19: Exploring coping strategies, distress, and post-traumatic growth during the COVID-19 pandemic in Australia
Coping with COVID-19: Exploring coping strategies, distress, and post-traumatic growth during the COVID-19 pandemic in Australia Open
Objective This study aimed to explore coping strategies, distress, and post-traumatic growth among Australians with and without a history of a mental health diagnosis during the COVID-19 pandemic. Materials and methods Australians ( N = 38…
View article: Cost-Utility and Cost-effectiveness of MoodSwings 2.0, an Internet-Based Self-management Program for Bipolar Disorder: Economic Evaluation Alongside a Randomized Controlled Trial
Cost-Utility and Cost-effectiveness of MoodSwings 2.0, an Internet-Based Self-management Program for Bipolar Disorder: Economic Evaluation Alongside a Randomized Controlled Trial Open
Background Internet-delivered psychosocial interventions can overcome barriers to face-to-face psychosocial care, but limited evidence supports their cost-effectiveness for people with bipolar disorders (BDs). Objective This study aimed to…
View article: Cost-utility and cost-effectiveness analyses of an internet-based self-management program for bipolar disorder: Randomised controlled trial (Preprint)
Cost-utility and cost-effectiveness analyses of an internet-based self-management program for bipolar disorder: Randomised controlled trial (Preprint) Open
BACKGROUND Internet delivered psychosocial interventions can overcome barriers with face-to-face psychosocial care. Limited evidence supports the cost-effectiveness of online psychosocial therapies for people with bipolar disorders. OBJ…
View article: 796Is Mindfulness a more effective intervention than Psychoeducation for reducing Bipolar Disorder-related symptoms of depression?
796Is Mindfulness a more effective intervention than Psychoeducation for reducing Bipolar Disorder-related symptoms of depression? Open
Background The primary objective is to test the effectiveness of a novel online quality of life (QoL) intervention tailored for people with late stage (≥ 10 episodes) bipolar disorder (BD) compared with psychoeducation. Relative to early s…
View article: Minocycline for the treatment of mental health and neurological conditions: study protocol of a systematic review and meta-analysis
Minocycline for the treatment of mental health and neurological conditions: study protocol of a systematic review and meta-analysis Open
Introduction Due to the anti-inflammatory, antioxidant and anti-apoptotic properties of minocycline, clinical trials have evaluated the potential of this drug to treat several psychiatric and neurological disorders, including major depress…
View article: Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial
Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial Open
ACTRN12612000283875.
View article: Integrating Delphi Consensus Consultation and Community- Based Participatory Research
Integrating Delphi Consensus Consultation and Community- Based Participatory Research Open
Delphi consensus consultation methods and community-based participatory research (CBPR) are distinct approaches that have traditionally been employed separately. This paper explores the integration of Delphi methods with CBPR in a research…
View article: Mental health information online: what we have learned from social media metrics in BuzzFeed’s Mental Health Week
Mental health information online: what we have learned from social media metrics in BuzzFeed’s Mental Health Week Open
Introduction The Internet has seen rapid growth in the number of websites focusing on mental health content. Considering the increased need for access to accurate information about mental health treatment, it is important to understand the…
View article: Web-based intervention to improve quality of life in late stage bipolar disorder (ORBIT): randomised controlled trial protocol
Web-based intervention to improve quality of life in late stage bipolar disorder (ORBIT): randomised controlled trial protocol Open
ClinicalTrials.gov : NCT03197974 . Registered 23 June 2017.
View article: A randomized controlled trial of MoodSwings 2.0: An internet‐based self‐management program for bipolar disorder
A randomized controlled trial of MoodSwings 2.0: An internet‐based self‐management program for bipolar disorder Open
Objectives MoodSwings 2.0 is an online self‐guided intervention for bipolar disorder that includes educational modules, interactive tools, and discussion forums. The primary aim of the study was to determine if participation in MoodSwings …
View article: Innovative content development for an online guided self‐help intervention for bipolar disorder: learnings from the orbit project
Innovative content development for an online guided self‐help intervention for bipolar disorder: learnings from the orbit project Open
Innovative content development for an online guided self-help intervention for bipolar disorder: learnings from the orbit project
View article: Mental health information online: what we have learned from social media metrics in BuzzFeed’s Mental Health Week
Mental health information online: what we have learned from social media metrics in BuzzFeed’s Mental Health Week Open
Introduction The Internet has seen rapid growth in the number of websites focusing on mental health content. Considering the increased need for access to accurate information about mental health treatment, it is important to understand the…
View article: Mental health information online: what we have learned from social media metrics in BuzzFeed’s Mental Health Week
Mental health information online: what we have learned from social media metrics in BuzzFeed’s Mental Health Week Open
Introduction The Internet has seen rapid growth in the number of websites focusing on mental health content. Considering the increased need for access to accurate information about mental health treatment, it is important to understand the…
View article: Staging in bipolar disorder: from theoretical framework to clinical utility
Staging in bipolar disorder: from theoretical framework to clinical utility Open
Illness staging is widely utilized in several medical disciplines to help predict course or prognosis, and optimize treatment. Staging models in psychiatry in general, and bipolar disorder in particular, depend on the premise that psychopa…
View article: Impact of irritability: a 2‐year observational study of outpatients with bipolar I or schizoaffective disorder
Impact of irritability: a 2‐year observational study of outpatients with bipolar I or schizoaffective disorder Open
Objectives Many people experience irritability when manic, hypomanic, or depressed, yet its impact on illness severity and quality of life in bipolar and schizoaffective disorders is poorly understood. This study aimed to examine the relat…