Lesley Gilbert
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View article: An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast Cancer
An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast Cancer Open
Estrogen receptor-positive (ER+) breast cancer carries a lifelong risk of recurrence and disease progression, with hypoxia-associated transcriptional signatures linked to poor prognosis and therapy resistance. While the effects of hypoxia …
View article: Ontogeny-independent expression of LPCAT2 in granuloma macrophages during experimental visceral leishmaniasis
Ontogeny-independent expression of LPCAT2 in granuloma macrophages during experimental visceral leishmaniasis Open
Granulomas are organized inflammatory lesions that form in response to persistent stimuli such as infections. Murine infection with Leishmania donovani results in the formation of granulomas around infected Kupffer cells in the liver and s…
View article: Assembly and annotation of <i>Solanum dulcamara</i> and <i>Solanum nigrum</i> plant genomes, two nightshades with contrasting susceptibilities to <i>Ralstonia solanacearum</i>
Assembly and annotation of <i>Solanum dulcamara</i> and <i>Solanum nigrum</i> plant genomes, two nightshades with contrasting susceptibilities to <i>Ralstonia solanacearum</i> Open
To understand why close wild plant relatives of crops, such as Solanum dulcamara, are resistant to Ralstonia solanacearum we need genome resources to perform comparative studies and identify key genes and pathways. We de-novo assembled and…
View article: IL-32–producing CD8+ memory T cells define immunoregulatory niches in human cutaneous leishmaniasis
IL-32–producing CD8+ memory T cells define immunoregulatory niches in human cutaneous leishmaniasis Open
Human cutaneous leishmaniasis (CL) is characterized by chronic skin pathology. Experimental and clinical data suggest that immune checkpoints (ICs) play a crucial role in disease outcome, but the cellular and molecular niches that facilita…
View article: Assembly and annotation of<i>Solanum dulcamara</i>and<i>Solanum nigrum</i>plant genomes, two nightshades with different susceptibilities to<i>Ralstonia solanacearum</i>
Assembly and annotation of<i>Solanum dulcamara</i>and<i>Solanum nigrum</i>plant genomes, two nightshades with different susceptibilities to<i>Ralstonia solanacearum</i> Open
To understand why close wild plant relatives of crops, such as Solanum dulcamara , are resistant to Ralstonia solanacearum we need genetic resources to perform comparative studies and identify key genes and pathways. We de-novo assembled a…
View article: Genome Assembly and Annotation of Vietnamese Rice Lines with Diverse Life-Cycle Durations
Genome Assembly and Annotation of Vietnamese Rice Lines with Diverse Life-Cycle Durations Open
This study begins by examining phenotypic variations in field growth among four parental Vietnamese rice lines, consisting of two Indica (PD211/GL37) and two Japonica (J23/SRA2-1) cultivars, which differ in life-cycle durations. Their phen…
View article: The rhythmic transcriptional landscape in<i>Caenorhabditis elegans</i>: daily, circadian and novel 16-hour cycling gene expression revealed by RNA-sequencing
The rhythmic transcriptional landscape in<i>Caenorhabditis elegans</i>: daily, circadian and novel 16-hour cycling gene expression revealed by RNA-sequencing Open
The nematode Caenorhabditis elegans is an unconventional model in chronobiology, reported to exhibit physiological and behavioural circadian rhythms while lacking a defined transcriptional oscillator. The extent and importance of circadian…
View article: IL-32 producing CD8<sup>+</sup>memory T cells and Tregs define the IDO1 / PD-L1 niche in human cutaneous leishmaniasis skin lesions
IL-32 producing CD8<sup>+</sup>memory T cells and Tregs define the IDO1 / PD-L1 niche in human cutaneous leishmaniasis skin lesions Open
Human cutaneous leishmaniasis (CL) is characterised by chronic skin pathology. Experimental and clinical data suggest that immune checkpoints (ICs) play a crucial role in disease outcome but the cellular and molecular niches that facilitat…
View article: UVB modifies skin immune-stroma cross-talk and promotes effector T cell recruitment during cryptic<i>Leishmania donovani</i>infection
UVB modifies skin immune-stroma cross-talk and promotes effector T cell recruitment during cryptic<i>Leishmania donovani</i>infection Open
SUMMARY Many parasites of significant public health importance assume skin residency without causing overt pathlogy. How immune and stromal cells respond to such “cryptic” infections and how exposure to UVB alters such responses in poorly …