Leslie G. Ratkay
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View article: Discovery of Piperazin-1-ylpyridazine-Based Potent and Selective Stearoyl-CoA Desaturase-1 Inhibitors for the Treatment of Obesity and Metabolic Syndrome
Discovery of Piperazin-1-ylpyridazine-Based Potent and Selective Stearoyl-CoA Desaturase-1 Inhibitors for the Treatment of Obesity and Metabolic Syndrome Open
Stearoyl-CoA desaturase-1 (SCD1) catalyzes de novo synthesis of monounsaturated fatty acids from saturated fatty acids. Studies have demonstrated that rodents lacking a functional SCD1 gene have an improved metabolic profile, including red…
View article: Investigation of an adjuvant-enhanced model of murine arthritis and its therapeutic application
Investigation of an adjuvant-enhanced model of murine arthritis and its therapeutic application Open
A major difficulty in understanding the etiology and pathogenic mechanisms of rheumatoid arthritis has been the lack of a suitable animal model. Based on the MRL-lpr spontaneous arthritis model, a new murine arthritis model was developed, …
View article: The effect of lactation in the post‐partum arthritis of MRL‐lpr/fasmice
The effect of lactation in the post‐partum arthritis of MRL‐lpr/fasmice Open
Our findings suggest that prolactin levels contribute to the inflammation seen in MRL-lpr/fas mice following parturition.
View article: Uptake of Verteporfin® by articular tissues following systemic and intra-articular administration
Uptake of Verteporfin® by articular tissues following systemic and intra-articular administration Open
Photodynamic therapy (PDT) using the photosensitizer BPD-Verteporfin (liposomal benzoporphyrin derivative-monoacid ring A) has been shown in previous studies to be effective in the amelioration of inflammatory arthritis in both the MRL-lpr…
View article: Evaluation of a model for post-partum arthritis and the role of oestrogen in prevention of MRL-<i>lpr</i>associated rheumatic conditions
Evaluation of a model for post-partum arthritis and the role of oestrogen in prevention of MRL-<i>lpr</i>associated rheumatic conditions Open
SUMMARY Sixty-eight percent of female MRL-lpr- mice developed a post-partum exacerbation of their mild spontaneous arthritis within 30 days of parturition- The flare became evident between 5 and 15 days after delivery. Histologically it wa…