Jieli Chen
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View article: Single-nuclei RNA sequencing unveils astrocyte and oligodendrocyte lineage cells in post-stroke human brain
Single-nuclei RNA sequencing unveils astrocyte and oligodendrocyte lineage cells in post-stroke human brain Open
This study provides a peri-infarct human cortical snRNA-seq atlas after IS, revealing coordinated glial transcriptional responses that promote cellular adaptation and repair. The upregulation of NMNAT2, HIF3A, NRP1, SEZ6L, and GPM6A highli…
View article: Bone marrow–derived emergency monopoiesis drives brain–lung axis injury after traumatic brain injury via IL-1
Bone marrow–derived emergency monopoiesis drives brain–lung axis injury after traumatic brain injury via IL-1 Open
View article: Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke
Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke Open
Chronic neuroinflammation is a major obstacle to post-stroke recovery, yet the underlying mechanisms, particularly the link between prolonged microglial activation and cholesterol metabolism, are not fully known. Here we show that ischaemi…
View article: Correction: Direct visualization endoscopic retrograde appendicitis therapy versus laparoscopic appendectomy for management of acute uncomplicated appendicitis
Correction: Direct visualization endoscopic retrograde appendicitis therapy versus laparoscopic appendectomy for management of acute uncomplicated appendicitis Open
[This corrects the article DOI: 10.1055/a-2638-6177.].
View article: Direct visualization endoscopic retrograde appendicitis therapy versus laparoscopic appendectomy for management of acute uncomplicated appendicitis
Direct visualization endoscopic retrograde appendicitis therapy versus laparoscopic appendectomy for management of acute uncomplicated appendicitis Open
Direct visualization endoscopic retrograde appendicitis therapy (ERAT), an advanced technique building upon conventional ERAT, represents a novel endoscopic approach for managing acute uncomplicated appendicitis. This study aimed to assess…
View article: Relieving oxidative stress microenvironment and promoting vascularized bone formation to treat femoral head necrosis using 3D-printed scaffold with ultralong-term multienzyme-like activity
Relieving oxidative stress microenvironment and promoting vascularized bone formation to treat femoral head necrosis using 3D-printed scaffold with ultralong-term multienzyme-like activity Open
PLGA has been already applied in clinical bone implants. Mn is an essential trace element for the human body and MnOx NPs offer the advantage of biocompatibility, ease of large-scale preparation, and low cost. Hence, this scaffo…
View article: Targeting CD38 to alleviate brain endothelial cell dysfunction and cognitive impairment in vascular dementia
Targeting CD38 to alleviate brain endothelial cell dysfunction and cognitive impairment in vascular dementia Open
Vascular dementia (VaD) is a leading cause of cognitive decline, closely associated with cerebrovascular endothelial cell (CEC) dysfunction, blood-brain barrier (BBB) disruption, and neuroinflammation. CD38, an enzyme implicated in neuroin…
View article: A retrospective observational study on prognostic factors in intermediate-high risk pulmonary embolism patients.
A retrospective observational study on prognostic factors in intermediate-high risk pulmonary embolism patients. Open
Introduction Pulmonary embolism (PE) is a common acute cardiovascular syndrome worldwide. Various environmental and genetic factors predispose to PE. Right ventricular (RV) failure is considered the cause of death. Risk stratification is m…
View article: Hyperbaric oxygen therapy in the treatment of severe gastric laceration with active bleeding: A case report
Hyperbaric oxygen therapy in the treatment of severe gastric laceration with active bleeding: A case report Open
BACKGROUND Endoscopic therapy is the primary approach for treating Mallory-Weiss syndrome, particularly under conditions of mucosal protection and gastric acid suppression. However, for a subset of patients who cannot undergo endoscopic in…
View article: Exploring the potential association between serum selenium and hypertension in obese adult males in the United States
Exploring the potential association between serum selenium and hypertension in obese adult males in the United States Open
View article: Microglia LILRB4 upregulation reduces brain damage after acute ischemic stroke by limiting CD8+ T cell recruitment
Microglia LILRB4 upregulation reduces brain damage after acute ischemic stroke by limiting CD8+ T cell recruitment Open
LILRB4 in microglia plays a crucial role in modulating the post-stroke immune response by regulating CD8+ T cell infiltration and activation. Knockout of LILRB4 exacerbates ischemic brain injury by promoting CD8+ T ce…
View article: Serum selenium accelerates the development of metabolic disorders in a metabolically healthy obese U.S. population: a retrospective cross-sectional analysis of a population-based study from the NHANES (2011-2018)
Serum selenium accelerates the development of metabolic disorders in a metabolically healthy obese U.S. population: a retrospective cross-sectional analysis of a population-based study from the NHANES (2011-2018) Open
Background Obesity represents a significant risk factor for the development of metabolic abnormalities. However, it is not inevitable that all individuals with obesity will develop these disorders. Selenium has been demonstrated to play a …
View article: Alleviating Recombinant Tissue Plasminogen Activator‐induced Hemorrhagic Transformation in Ischemic Stroke via Targeted Delivery of a Ferroptosis Inhibitor
Alleviating Recombinant Tissue Plasminogen Activator‐induced Hemorrhagic Transformation in Ischemic Stroke via Targeted Delivery of a Ferroptosis Inhibitor Open
Intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) is the primary treatment for ischemic stroke. However, rtPA treatment can substantially increase blood‐brain barrier (BBB) permeability and susceptibility to hem…
View article: Vanillic acid restores homeostasis of intestinal epithelium in colitis through inhibiting CA9/STIM1-mediated ferroptosis
Vanillic acid restores homeostasis of intestinal epithelium in colitis through inhibiting CA9/STIM1-mediated ferroptosis Open
The damage of integrated epithelial epithelium is a key pathogenic factor and closely associated with the recurrence of ulcerative colitis (UC). Here, we reported that vanillic acid (VA) exerted potent therapeutic effects on DSS-induced co…
View article: A Highly Active and Stable Single-Atom Catalyst for Oxygen Reduction with Axial Fe-O Coordination Prepared Through a Fast Medium-Temperature Pyrolysis Process
A Highly Active and Stable Single-Atom Catalyst for Oxygen Reduction with Axial Fe-O Coordination Prepared Through a Fast Medium-Temperature Pyrolysis Process Open
View article: Emerging story of gut dysbiosis in spondyloarthropathy: From gastrointestinal inflammation to spondyloarthritis
Emerging story of gut dysbiosis in spondyloarthropathy: From gastrointestinal inflammation to spondyloarthritis Open
As a set of inflammatory disorders, spondyloarthritis (SpA) exhibits distinct pathophysiological, clinical, radiological, and genetic characteristics. Due to the extra-articular features of this disorder, early recognition is crucial to li…
View article: Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1
Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1 Open
View article: Analysis of the Role of Chinese and American Supervisors of Internship Placement-Taking the University of Cincinnati's School-Enterprise Cooperation Model as an Example
Analysis of the Role of Chinese and American Supervisors of Internship Placement-Taking the University of Cincinnati's School-Enterprise Cooperation Model as an Example Open
The University of Cincinnati is the birthplace of the global paid internship program and has the most professional paid internship instructors in the United States. The University of Cincinnati has the most professional paid internship ins…
View article: Deficiency of Endothelial Nitric Oxide Synthase (eNOS) Exacerbates Brain Damage and Cognitive Deficit in A Mouse Model of Vascular Dementia
Deficiency of Endothelial Nitric Oxide Synthase (eNOS) Exacerbates Brain Damage and Cognitive Deficit in A Mouse Model of Vascular Dementia Open
Vascular Dementia (VaD) accounts for nearly 20% of all cases of dementia. eNOS plays an important role in neurovascular remodeling, anti-inflammation, and cognitive functional recovery after stroke. In this study, we investigated whether e…
View article: Insights from the University of Cincinnati Paid Internship Education Program
Insights from the University of Cincinnati Paid Internship Education Program Open
The University of Cincinnati is the birthplace of the paid internship program in the world and it has the most number of compulsory paid internship programs in the United States. Their paid internship education program has rich experience …
View article: Multifaceted roles of pericytes-interorgan interactions
Multifaceted roles of pericytes-interorgan interactions Open
Microvascular dysfunction has been implicated in many diseases such as stroke and diabetes. In addition to the microvascular endothelial cell (EC), the pericyte, a perivascular cell that adheres to the abluminal side of the EC may also be …
View article: HUCBC Treatment Improves Cognitive Outcome in Rats With Vascular Dementia
HUCBC Treatment Improves Cognitive Outcome in Rats With Vascular Dementia Open
Background and purpose: Vascular dementia (VaD) is the second common cause of dementia after Alzheimer's disease in older people. Yet, there are no FDA approved drugs specifically for VaD. In this study, we have investigated the the…
View article: ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke
ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke Open
ATP-binding cassette transporter A1 (ABCA1) plays an important role in the regulation of apolipoprotein E (ApoE) and the biogenesis of high-density lipoprotein (HDL) cholesterol in the mammalian brain. Cholesterol is a major source for mye…
View article: Multifaceted roles of pericytes in central nervous system homeostasis and disease
Multifaceted roles of pericytes in central nervous system homeostasis and disease Open
Pericytes, the mural cells surrounding microcirculation, are gaining increasing attention for their roles in health and disease of the central nervous system (CNS). As an essential part of the neurovascular unit (NVU), pericytes are active…
View article: CD133+Exosome Treatment Improves Cardiac Function after Stroke in Type 2 Diabetic Mice
CD133+Exosome Treatment Improves Cardiac Function after Stroke in Type 2 Diabetic Mice Open
View article: Brain-Derived Microparticles (BDMPs) Contribute to Neuroinflammation and Lactadherin Reduces BDMP Induced Neuroinflammation and Improves Outcome After Stroke
Brain-Derived Microparticles (BDMPs) Contribute to Neuroinflammation and Lactadherin Reduces BDMP Induced Neuroinflammation and Improves Outcome After Stroke Open
Microparticles (MPs, ~size between 0.1 and 1 mm) are lipid encased containers derived from intact cells which contain antigen from the parent cells. MPs are involved in intercellular communication and regulate inflammation. Stroke increase…
View article: Brain–kidney interaction: Renal dysfunction following ischemic stroke
Brain–kidney interaction: Renal dysfunction following ischemic stroke Open
Stroke is a leading cause of mortality and morbidity, with long-term debilitating effects. Accumulating evidence from experimental studies as well as observational studies in patients suggests a cross talk between the brain and kidney afte…
View article: ApoA-I Mimetic Peptide Reduces Vascular and White Matter Damage After Stroke in Type-2 Diabetic Mice
ApoA-I Mimetic Peptide Reduces Vascular and White Matter Damage After Stroke in Type-2 Diabetic Mice Open
Diabetes leads to an elevated risk of stroke and worse functional outcome compared to the general population. We investigate whether L-4F, an economical ApoA-I mimetic peptide, reduces neurovascular and white-matter damage in db/db type-2 …
View article: MiR-126 Mediates Brain Endothelial Cell Exosome Treatment–Induced Neurorestorative Effects After Stroke in Type 2 Diabetes Mellitus Mice
MiR-126 Mediates Brain Endothelial Cell Exosome Treatment–Induced Neurorestorative Effects After Stroke in Type 2 Diabetes Mellitus Mice Open
Background and Purpose— Stroke patients with type 2 diabetes mellitus (T2DM) exhibit increased vascular and white matter damage and have worse prognosis compared with nondiabetic stroke patients. We investigated the neurorestorative effect…
View article: Deficiency of tPA Exacerbates White Matter Damage, Neuroinflammation, Glymphatic Dysfunction and Cognitive Dysfunction in Aging Mice
Deficiency of tPA Exacerbates White Matter Damage, Neuroinflammation, Glymphatic Dysfunction and Cognitive Dysfunction in Aging Mice Open
Tissue plasminogen activator (tPA) is a serine protease primarily involved in mediating thrombus breakdown and regulating catabolism of amyloid-beta (Aβ). The aim of this study is to investigate age-dependent decline of endogenous tPA and …