Lanjuan Li
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View article: B. adolescentis alleviates inflammation and suppresses PGE2 through remodling gut microbiota to attenuate pulmonary fibrosis in aging mice
B. adolescentis alleviates inflammation and suppresses PGE2 through remodling gut microbiota to attenuate pulmonary fibrosis in aging mice Open
The global burden of pulmonary fibrosis is increasing. Recent studies have shown that some pulmonary fibrotic lesions caused by COVID-19 infection may persist for a long time. Emerging evidence suggested a critical association between gut …
View article: Protective Effect of <i>Pediococcus pentosaceus</i> Li05 on Constipation via TGR5/TPH1/5‐HT Activation
Protective Effect of <i>Pediococcus pentosaceus</i> Li05 on Constipation via TGR5/TPH1/5‐HT Activation Open
Pediococcus pentosaceus Li05, a strain of lactic acid bacteria isolated from the faeces of healthy volunteers, exhibited potential protective effects against various diseases. This study performed third‐generation sequencing and detailed c…
View article: The impact of airway management guided by Protection Motivation Theory on the prevention and prognosis of post-stroke pneumonia
The impact of airway management guided by Protection Motivation Theory on the prevention and prognosis of post-stroke pneumonia Open
Background Stroke remains a leading cause of morbidity and mortality worldwide, with post-stroke pneumonia significantly impacting patient outcomes. Despite progress in stroke management, there was a lack of emphasis on targeted preventive…
View article: Lactobacillus helveticus R0052 attenuates DSS-induced colitis via modulation of gut microbiota, intestinal metabolites and immunological profiles in a mouse model
Lactobacillus helveticus R0052 attenuates DSS-induced colitis via modulation of gut microbiota, intestinal metabolites and immunological profiles in a mouse model Open
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) pathologically characterized by intestinal immune dysregulation, and substantial clinical evidence suggests that probiotic supplementation demonstrates efficacy and safe…
View article: Bioartificial liver: Where lies the path ahead—A review
Bioartificial liver: Where lies the path ahead—A review Open
Despite its proven effectiveness in treating liver failure, liver transplantation is often impractical due to its high surgical risks involved and the limited availability of donor organs. Blood purification technologies used in non-bioart…
View article: Quantum dot immunochromatographic strip for rapid and sensitive detection of H5 subtype avian influenza virus
Quantum dot immunochromatographic strip for rapid and sensitive detection of H5 subtype avian influenza virus Open
The H5 subtype avian influenza viruses (AIVs) pose a major threat to wild fowl and poultry. Additionally, they can overcome the species barrier, inducing human infection, which may become fatal. Thus, the H5 subtype AIVs remain a global pu…
View article: Gut microbiota links to histological damage in chronic HBV infection patients and aggravates fibrosis via fecal microbiota transplantation in mice
Gut microbiota links to histological damage in chronic HBV infection patients and aggravates fibrosis via fecal microbiota transplantation in mice Open
Gut microbiota dysbiosis has been observed in HBV-related cirrhosis, but its role in early-stage disease and its correlation with liver pathology remain unclear. Moreover, whether dysbiosis is a cause or consequence of liver cirrhosis is s…
View article: Evolving therapeutic strategies for severe fever with thrombocytopenia syndrome: from past to future
Evolving therapeutic strategies for severe fever with thrombocytopenia syndrome: from past to future Open
Severe fever with thrombocytopenia syndrome (SFTS) is a hemorrhagic fever caused by Bandavirus dabieense . SFTS was first identified in China in 2009 and has been reported since then in neighboring countries and regions. The clinical manif…
View article: Effects of Biofilm Formation on Gastrointestinal Tolerance, Mucoadhesion and Transcriptomic Responses of Probiotics
Effects of Biofilm Formation on Gastrointestinal Tolerance, Mucoadhesion and Transcriptomic Responses of Probiotics Open
Probiotic health benefits may be affected by decreased viability during food storage and gastrointestinal transit. Although microencapsulation is an effective protective strategy, its application to probiotics is limited. Currently, resear…
View article: Chemokines: Orchestration of the Tumor Microenvironment and Control of Hepatocellular Carcinoma Progression
Chemokines: Orchestration of the Tumor Microenvironment and Control of Hepatocellular Carcinoma Progression Open
Chemokines, a family of chemotactic cytokines, play a central role in shaping the tumor microenvironment (TME) and in influencing the progression of hepatocellular carcinoma (HCC), a well‐known inflammation‐related cancer. This review addr…
View article: Expert Consensus on the Clinical Application of Thymosin Alpha 1 in Infectious Diseases and Critical Care Medicine
Expert Consensus on the Clinical Application of Thymosin Alpha 1 in Infectious Diseases and Critical Care Medicine Open
As immunotherapy gains increasing attention and clinical application, the immune modulation therapy has been widely used in the treatment of infectious and critical diseases. Clinical evidence has been accumulated for application of thymos…
View article: A human-infecting H10N5 avian influenza virus: Clinical features, virus reassortment, receptor-binding affinity, and possible transmission routes
A human-infecting H10N5 avian influenza virus: Clinical features, virus reassortment, receptor-binding affinity, and possible transmission routes Open
Unlike the human-infecting H10N3 and H10N8 AIVs acquiring six internal protein-coding genes from H9N2 AIVs in domestic poultry, the human-infecting H10N5 AIV was generated through multiple reassortments among viruses mainly carried by wild…
View article: Short-term subacute di(2-ethylhexyl) phthalate exposure disrupts gut microbiota, metabolome, liver transcriptome, immunity, and induces liver injury in rats
Short-term subacute di(2-ethylhexyl) phthalate exposure disrupts gut microbiota, metabolome, liver transcriptome, immunity, and induces liver injury in rats Open
Di(2-ethylhexyl) phthalate (DEHP) is recognised as a pollutant with multiple health risks. In this study, multi-omics approaches were used to examine the alterations in immunity, gut microbiota and metabolome, and liver transcriptome in th…
View article: P-285. Effects of Comorbidities and Charlson Comorbidity Index Application on Patient Outcomes in Blood and Respiratory Carbapenem-Resistant Gram-Negative Bacterial Infections
P-285. Effects of Comorbidities and Charlson Comorbidity Index Application on Patient Outcomes in Blood and Respiratory Carbapenem-Resistant Gram-Negative Bacterial Infections Open
Background Infections with carbapenem-resistant (CR) organisms are more likely in patients with comorbidities and are associated with worse prognosis. The effect of specific and multiple comorbidities on the outcomes of patients with CR in…
View article: Hazard assessment of airborne and foodborne biodegradable polyhydroxyalkanoates microplastics and non-biodegradable polypropylene microplastics
Hazard assessment of airborne and foodborne biodegradable polyhydroxyalkanoates microplastics and non-biodegradable polypropylene microplastics Open
Microplastics (MP) are ubiquitous in the environment, and are toxic to various living organisms. Proper application of biodegradable plastics may alleviate the hazards of conventional non-biodegradable plastics. In the current study, multi…
Severe fever with thrombocytopenia syndrome complicated with aspergillus endocarditis and multiple organ infarctions after glucocorticoid treatment in an immunocompetent man: a case report Open
Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease characterized by leukopenia and thrombocytopenia, and aspergillosis is a common complication in severe cases. Previous studies have reported ca…
View article: PPARα agonist ameliorates cholestatic liver injury by regulating hepatic macrophage homeostasis
PPARα agonist ameliorates cholestatic liver injury by regulating hepatic macrophage homeostasis Open
Inflammatory response plays an essential role in the pathogenesis of cholestatic liver injury. PPARα agonists have been shown to regulate bile acid homeostasis and hepatic inflammation. However, the immunoregulatory mechanisms through whic…
View article: The Causal Effect Between Human Microbiota and Scabies: A Study from the Genetic Perspective
The Causal Effect Between Human Microbiota and Scabies: A Study from the Genetic Perspective Open
Overall, our results demonstrate a causal relationship between intestinal and skin flora and scabies and are consistent with previous observational findings. This will contribute to the future development of probiotic agents for the preven…
View article: Modulation of gut microbiota by probiotics to improve the efficacy of immunotherapy in hepatocellular carcinoma
Modulation of gut microbiota by probiotics to improve the efficacy of immunotherapy in hepatocellular carcinoma Open
Hepatocellular carcinoma, a common malignancy of the digestive system, typically progresses through a sequence of hepatitis, liver fibrosis, cirrhosis and ultimately, tumor. The interaction between gut microbiota, the portal venous system …